Search
Search Results
-
PD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity
Combination therapy with PD-1 blockade and IL-2 substantially improves anti-tumor efficacy comparing to monotherapy. The underlying mechanisms...
-
Systematic investigation of cytokine signaling activity at the tissue and single-cell levels
Cytokines are critical for intercellular communication in human health and disease, but the investigation of cytokine signaling activity has remained...
-
Influence of Suppressor of Cytokine Signaling 1 (SOCS1) Gene Variations on Polycystic Ovary Syndrome
Polycystic ovarian syndrome (PCOS) is associated with low-grade systemic inflammation and an increase in inflammation markers, which are crucial in...
-
Dickkopf1 fuels inflammatory cytokine responses
Many human diseases, including cancer, share an inflammatory component but the molecular underpinnings remain incompletely understood. We report that...
-
The interplay of cytokine signaling and non-coding RNAs in head and neck squamous cell carcinoma pathobiology
Head and neck squamous cell carcinoma (HNSCC) is a leading cause of cancer-related death worldwide. Despite aggressive treatment approaches, the...
-
CytoSIP: an annotated structural atlas for interactions involving cytokines or cytokine receptors
Therapeutic agents targeting cytokine-cytokine receptor (CK-CKR) interactions lead to the disruption in cellular signaling and are effective in...
-
Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy
Dendritic cells (DCs) are antigen-presenting myeloid cells that regulate T cell activation, trafficking and function. Monocyte-derived DCs pulsed...
-
NFAT1 and NFκB regulates expression of the common γ-chain cytokine receptor in activated T cells
IntroductionCytokines of the common γ chain (γc) family are critical for the development, differentiation, and survival of T lineage cells. Cytokines...
-
The ROCK-ezrin signaling pathway mediates LPS-induced cytokine production in pulmonary alveolar epithelial cells
BackgroundEzrin/radixin/moesin (ERM) proteins are members of the protein 4.1 superfamily and function as linkers that connect the actin cytoskeleton...
-
Tim-3/Galectin-9 signaling pathway is involved in the cytokine changes in mice with alveolar echinococcosis
BackgroundTim-3/Galectin-9 is involved in the immune escape of many pathogens. However, the role of Tim-3/Galectin-9 in persistent infection of Echino...
-
Cytokine signaling convergence regulates the microglial state transition in Alzheimer’s disease
Genetic analyses have revealed the pivotal contribution of microglial dysfunctions to the pathogenesis of Alzheimer’s disease (AD). Along AD...
-
Multi-omics delineation of cytokine-induced endothelial inflammatory states
Vascular endothelial cells (ECs) form a dynamic interface between blood and tissue and play a crucial role in the progression of vascular...
-
Protein arginine methyltransferase 2 controls inflammatory signaling in acute myeloid leukemia
Arginine methylation is catalyzed by protein arginine methyltransferases (PRMTs) and is involved in various cellular processes, including cancer...
-
Human placental mesenchymal stromal cell therapy restores the cytokine efflux and insulin signaling in the skeletal muscle of obesity-induced type 2 diabetes rat model
Obesity poses a significant risk factor for the onset of metabolic syndrome with allied complications, wherein mesenchymal stem cell therapy is seen...
-
Taming the cytokine storm: small molecule inhibitors targeting IL-6/IL-6α receptor
Given the increasing effectiveness of immune-based therapies, management of their associated toxicities is of utmost importance. Cytokine release...
-
Effect of Ionizing Radiation on the Cytokine Status (Review of the Literature)
Abstract —The data on cytokine expression in humans and animals after radiation exposure is reviewed. Cytokines are biologically active hormone-like...
-
Regulation of β-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis
BackgroundLipids are regulators of insulitis and β-cell death in type 1 diabetes development, but the underlying mechanisms are poorly understood....
-
IDH2/R140Q mutation confers cytokine-independent proliferation of TF-1 cells by activating constitutive STAT3/5 phosphorylation
BackgroundR140Q mutation in isocitrate dehydrogenase 2 (IDH2) promotes leukemogenesis. Targeting IDH2/R140Q yields encouraging therapeutic effects in...
-
Wnt signaling regulates chemokine production and cell migration of circulating human monocytes
The β-catenin dependent canonical Wnt signaling pathway plays a crucial role in maintaining normal homeostasis. However, when dysregulated, Wnt...
-
Experiment-based computational model predicts that IL-6 classic and trans-signaling exhibit similar potency in inducing downstream signaling in endothelial cells
Inflammatory cytokine mediated responses are important in the development of many diseases that are associated with angiogenesis. Targeting...
