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Functional and structural analysis of a cyclization domain in a cyclic β-1,2-glucan synthase
AbstractCyclic β-1,2-glucan synthase (CGS) is a key enzyme in production of cyclic β-1,2-glucans (CβGs) which are involved in bacterial infection or...
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Metal-free 2-isocyanobiaryl-based cyclization reactions: phenanthridine framework synthesis
The development of transition metal-free 2-isocyanobiaryl-based reactions has received much attention due to the widespread presence of phenanthidine...
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Improving the specific activity and stability of alkaline pectinase PEL3 through SpyTag/SpyCatcher cyclization
ObjectivesPEL3, an alkaline pectinase, exhibited the highest activity among documented alkaline pectate lyases reported in our early study....
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Asymmetric synthesis of spiro[4H-chromene-3,3′-oxindoles] via a squaramide-organocatalytic three-component cascade Knoevenagel/Michael/cyclization sequence
Asymmetric synthesis of spiro[4 H -chromene-3,3′-oxindole] derivatives was realized through an organocatalytic cascade Knoevenagel/Michael/cyclization...
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Intramolecular cyclization of isothiocyanyl amino acids/peptide: arrival at unnatural thioxoimidazolidinyl/thioxooxazolidinyl amino acids
A novel intramolecular cyclization of isothiocyanyl amino acids/peptide is reported to arrive at unnatural thioxoimidazolidinyl...
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Enhancing the Stability of Tumor Homing LyP-1 Peptide Using Cyclization and Retro Grafting Strategies
Anticancer peptide therapeutics are promising candidates for cancer treatment as they are highly specific to their targets and can have tumor-homing...
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Prodigiosin R3, a new multicyclic prodigiosin formed by prodigiosin cyclization genes in the roseophilin producer
The rph gene cluster for prodigiosin biosynthesis has been identified in Streptomyces griseoviridis 2464-S5, which produces cyclic prodigiosin...
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Synthesis of fused polycyclic β-carboline derivatives using Ugi-4CR followed by cascade cyclization
Ugi-four component reaction (Ugi-4CR) is extremely attractive for diversity-oriented and step economical synthesis as evident from past applications....
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Effect of SpyTag/SpyCatcher cyclization on stability and refolding of green fluorescent protein
To study the effect of SpyTag/SpyCatcher cyclization on stability and refolding of protein, we constructed a cyclized green fluorescent protein...
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Applications of biaryl cyclization in the synthesis of cyclic enkephalin analogs with a highly restricted flexibility
A series of 10 cyclic, biaryl analogs of enkephalin, with Tyr or Phe residues at positions 1 and 4, were synthesized according to the Miyaura...
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Hydroxymethylation hydroxylation of 1,3-diarylpropene through a catalytic diastereoselective Prins reaction: cyclization logic and access to brazilin core
A catalytic diastereoselective Prins reaction for hydroxymethylation and hydroxylation of 1,3-diarylpropene was successfully utilized to prepare...
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Domino synthesis of 5-aminoimidazoles from Strecker multicomponent adducts via ytterbium-promoted isocyanide insertion/5-exo-dig cyclization
A new Lewis acid promoted domino isocyanide insertion/5- exo - dig cyclization of readily available Strecker 3-component adducts to 4-substituted...
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Synthesis of functionalized pyrrole derivatives via diverse cyclization of azomethine ylide and olefins
The azomethine ylides are generally used in 1,3-dipolar cycloadditions with various dipolarophiles. In this work, a new and diverse route has been...
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Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases
Cyclic disulfide-rich peptides have attracted significant interest in drug development and biotechnology. Here, we describe a protocol for producing...
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Eco-friendly and regiospecific intramolecular cyclization reactions of cyano and carbonyl groups in N,N-disubstituted cyanamide
Eco-friendly, low-cost and high-yielding synthetic route toward imidazoles and oxazoles has been developed....
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A Chemoenzymatic Approach to Investigate Cytochrome P450 Cross-Linking in Glycopeptide Antibiotic Biosynthesis
Glycopeptide antibiotics (GPAs) are important and medically relevant peptide natural products. In the context of antimicrobial resistance (AMR),...
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The RNA secondary structural variation in the cyclization elements of the dengue genome and the possible implications in pathogenicity
Dengue virus (DENV), the causative agent of dengue fever and severe dengue, exists as four antigenically different serotypes. These serotypes are...
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Squalene hopene cyclases and oxido squalene cyclases: potential targets for regulating cyclisation reactions
Squalene hopene cyclases (SHC) convert squalene, the linear triterpene to fused ring product hopanoid by the cationic cyclization mechanism. The main...
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Enhanced stability of a rumen-derived xylanase using SpyTag/SpyCatcher cyclization
Microbiota from herbivore rumen is of great interest for mining glycoside hydrolases for lignocellulosic biomass biorefinement. We previously...
