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Mechanical disengagement of the cohesin ring
Cohesin forms a proteinaceous ring that is thought to link sister chromatids by entrap** DNA and counteracting the forces generated by the mitotic...
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Cohesin Complex: Structure and Principles of Interaction with DNA
AbstractAccurate duplication and separation of long linear genomic DNA molecules is associated with a number of purely mechanical problems. SMC...
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PCNA recruits cohesin loader Scc2 to ensure sister chromatid cohesion
Sister chromatid cohesion, established during replication by the ring-shaped multiprotein complex cohesin, is essential for faithful chromosome...
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Cohesin-Dependent Loop Extrusion: Molecular Mechanics and Role in Cell Physiology
AbstractThe most prominent representatives of multisubunit SMC complexes, cohesin and condensin, are best known as structural components of mitotic...
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A cohesin traffic pattern genetically linked to gene regulation
Cohesin-mediated loop extrusion has been shown to be blocked at specific cis -elements, including CTCF sites, producing patterns of loops and domain...
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RAD21 is the core subunit of the cohesin complex involved in directing genome organization
BackgroundThe ring-shaped cohesin complex is an important factor for the formation of chromatin loops and topologically associating domains (TADs) by...
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ATM signaling modulates cohesin behavior in meiotic prophase and proliferating cells
Cohesins are ancient and ubiquitous regulators of chromosome architecture and function, but their diverse roles and regulation remain poorly...
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ChIPr: accurate prediction of cohesin-mediated 3D genome organization from 2D chromatin features
The three-dimensional genome organization influences diverse nuclear processes. Here we present Chromatin Interaction Predictor (ChIPr), a suite of...
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Replisome-cohesin interactions provided by the Tof1-Csm3 and Mrc1 cohesion establishment factors
The chromosomal cohesin complex establishes sister chromatid cohesion during S phase, which forms the basis for faithful segregation of DNA...
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The cohesin modifier ESCO2 is stable during DNA replication
Cohesion between sister chromatids by the cohesin protein complex ensures accurate chromosome segregation and enables recombinational DNA repair....
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CTCF–CTCF loops and intra-TAD interactions show differential dependence on cohesin ring integrity
The ring-like cohesin complex mediates sister-chromatid cohesion by encircling pairs of sister chromatids. Cohesin also extrudes loops along...
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Contribution of variant subunits and associated factors to genome-wide distribution and dynamics of cohesin
BackgroundThe cohesin complex organizes the genome-forming dynamic chromatin loops that impact on all DNA-mediated processes. There are two different...
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CTCF and cohesin promote focal detachment of DNA from the nuclear lamina
BackgroundLamina-associated domains (LADs) are large genomic regions that are positioned at the nuclear lamina. It has remained largely unclear what...
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Cohesin is required for long-range enhancer action at the Shh locus
The regulatory landscapes of developmental genes in mammals can be complex, with enhancers spread over many hundreds of kilobases. It has been...
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PDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome
BackgroundCohesin is an important structural regulator of the genome, regulating both three-dimensional genome organization and gene expression. The...
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The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism
Cohesin structures the genome through the formation of chromatin loops and by holding together the sister chromatids. The acetylation of cohesin’s...
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Chromosomal localization of cohesin is differentially regulated by WIZ, WAPL, and G9a
BackgroundThe cohesin complex is essential for proper chromosome structure and gene expression. Defects in cohesin subunits and regulators cause...
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Smc3 acetylation, Pds5 and Scc2 control the translocase activity that establishes cohesin-dependent chromatin loops
Cohesin is a DNA translocase that is instrumental in the folding of the genome into chromatin loops, with functional consequences on DNA-related...
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A Robust Protocol for Investigating the Cohesin Complex by ChIP-Sequencing
The investigation of cohesin binding sites throughout different mammalian genomes by ChIP-sequencing has been fundamental to discover how cohesin and...
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Cohesin regulates homology search during recombinational DNA repair
Homologous recombination repairs DNA double-strand breaks (DSB) using an intact dsDNA molecule as a template. It entails a homology search step,...
