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Single Cell Atlas: a single-cell multi-omics human cell encyclopedia
Single-cell sequencing datasets are key in biology and medicine for unraveling insights into heterogeneous cell populations with unprecedented...
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Aging atlas reveals cell-type-specific effects of pro-longevity strategies
Organismal aging involves functional declines in both somatic and reproductive tissues. Multiple strategies have been discovered to extend lifespan...
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scDiffCom: a tool for differential analysis of cell–cell interactions provides a mouse atlas of aging changes in intercellular communication
Dysregulation of intercellular communication is a hallmark of aging. To better quantify and explore changes in intercellular communication, we...
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Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlas
Although multiple pancreatic islet single-cell RNA-sequencing (scRNA-seq) datasets have been generated, a consensus on pancreatic cell states in...
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A lamprey neural cell type atlas illuminates the origins of the vertebrate brain
The vertebrate brain emerged more than ~500 million years ago in common evolutionary ancestors. To systematically trace its cellular and molecular...
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A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets
Recent longitudinal studies of glioblastoma (GBM) have demonstrated a lack of apparent selection pressure for specific DNA mutations in recurrent...
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Waxholm Space atlas of the rat brain: a 3D atlas supporting data analysis and integration
Volumetric brain atlases are increasingly used to integrate and analyze diverse experimental neuroscience data acquired from animal models, but until...
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An atlas of rabbit development as a model for single-cell comparative genomics
Traditionally, the mouse has been the favoured vertebrate model for biomedical research, due to its experimental and genetic tractability. However,...
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Spatially resolved cell atlas of the teleost telencephalon and deep homology of the vertebrate forebrain
The telencephalon has undergone remarkable diversification and expansion throughout vertebrate evolution, exhibiting striking variations in...
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An atlas of spider development at single-cell resolution provides new insights into arthropod embryogenesis
Spiders are a diverse order of chelicerates that diverged from other arthropods over 500 million years ago. Research on spider embryogenesis,...
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Inferring gene regulatory networks from single-cell multiome data using atlas-scale external data
Existing methods for gene regulatory network (GRN) inference rely on gene expression data alone or on lower resolution bulk data. Despite the recent...
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Single-nucleus transcriptome sequencing reveals hepatic cell atlas in pigs
BackgroundAs the largest substantive organ of animals, the liver plays an essential role in the physiological processes of digestive metabolism and...
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A human stomach cell type transcriptome atlas
BackgroundThe identification of cell type-specific genes and their modification under different conditions is central to our understanding of human...
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A single-cell atlas of lung homeostasis reveals dynamic changes during development and aging
Aging is a global challenge, marked in the lungs by function decline and structural disorders, which affects the health of the elderly population. To...
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Single-cell transcriptomic atlas of goat ovarian aging
BackgroundThe ovaries are one of the first organs that undergo degenerative changes earlier in the aging process, and ovarian aging is shown by a...
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Updated single cell reference atlas for the starlet anemone Nematostella vectensis
BackgroundThe recent combination of genomics and single cell transcriptomics has allowed to assess a variety of non-conventional model organisms in...
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An atlas of lamina-associated chromatin across twelve human cell types reveals an intermediate chromatin subtype
BackgroundAssociation of chromatin with lamin proteins at the nuclear periphery has emerged as a potential mechanism to coordinate cell type-specific...
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A single-cell transcriptome atlas profiles early organogenesis in human embryos
The early window of human embryogenesis is largely a black box for developmental biologists. Here we probed the cellular diversity of 4–6 week human...
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A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung
The lung contains numerous specialized cell types with distinct roles in tissue function and integrity. To clarify the origins and mechanisms...
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A single-cell atlas of conventional central chondrosarcoma reveals the role of endoplasmic reticulum stress in malignant transformation
The transformation of benign lesions to malignant tumours is a crucial aspect of understanding chondrosarcomas, which are malignant cartilage tumours...
