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The MMP-9 promoter genetic variant rs3918242, mRNA and protein expression in advanced carotid plaque tissue
BackgroundThe MMP-9 is a known player in atherosclerosis, yet associations of the MMP-9 -1562 C/T variant (rs3918242) with various atherosclerotic...
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The blood monocyte to high density lipoprotein cholesterol ratio (MHR) is a possible marker of carotid artery plaque
BackgroundMHR is the ratio of monocyte to high-density lipoprotein cholesterol (HDL-C). It has been reported that MHR changes are associated with...
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Defining Characteristics of Angiogenesis Regulation in Advanced Human Carotid Plaques
AbstractIncreased neovascularization of the atherosclerotic plaque promotes plaque vulnerability, atherosclerosis progression, and increased risk of...
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Quantitative proteomic landscape of unstable atherosclerosis identifies molecular signatures and therapeutic targets for plaque stabilization
Atherosclerotic plaque rupture leading to myocardial infarction is a major global health burden. Applying the tandem stenosis (TS) mouse model, which...
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SIRT6 promotes angiogenesis and hemorrhage of carotid plaque via regulating HIF-1α and reactive oxygen species
As a member of Sirtuins family, SIRT6 participates in the physiological and pathological progress of DNA repair, anti-aging, metabolism, and so on....
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Role of sirtuins in attenuating plaque vulnerability in atherosclerosis
Atherosclerosis is characterized by the development of intimal plaque, thrombosis, and stenosis of the vessel lumen causing decreased blood flow and...
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Methylation of Regulatory Regions of DNA Repair Genes in Carotid Atherosclerosis
AbstractThe status of DNA methylation in the human genome changes during the pathogenesis of common diseases and acts as a predictor of life...
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Decoding the transcriptome of calcified atherosclerotic plaque at single-cell resolution
Atherogenesis involves an interplay of inflammation, tissue remodeling and cellular transdifferentiation (CTD), making it especially difficult to...
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Assessment of cerebral autoregulatory function and inter-hemispheric blood flow in older adults with internal carotid artery stenosis using transcranial Doppler sonography-based measurement of transient hyperemic response after carotid artery compression
Unhealthy vascular aging promotes atherogenesis, which may lead to significant internal carotid artery stenosis (CAS) in 5 to 7.5% of older adults....
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Carotid disease, cognition, and aging: time to redefine asymptomatic disease?
There is an increasing appreciation of the vascular contributions in the development of age-related cognitive impairment and dementia 1,2 . Identifying...
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Cerebrovascular dysregulation and postoperative cognitive alterations after carotid endarterectomy
There are controversial data about the effect of carotid endarterectomy regarding postoperative cognitive function. Our aim was to analyze the effect...
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Polo-like kinase 4 inhibitor CFI-400945 inhibits carotid arterial neointima formation but increases atherosclerosis
Neointima lesion and atherosclerosis are proliferative vascular diseases associated with deregulated proliferation of vascular smooth muscle cells...
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Loss of soluble guanylyl cyclase in platelets contributes to atherosclerotic plaque formation and vascular inflammation
Variants in genes encoding the soluble guanylyl cyclase (sGC) in platelets are associated with coronary artery disease (CAD) risk. Here, by using...
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Dilated hypertrophic phenotype of the carotid artery is associated with accelerated age-associated central arterial stiffening
AbstractHypertrophic carotid geometric phenotypes (h-CGP) are predictors of incident cardiovascular disease (CVD). While arterial aging is...
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Evaluation of Plaque Burden and Lipid Content in Atherosclerotic Plaques
Atherosclerosis is a chronic inflammatory disease characterized by the formation of lipid-rich, fibrous plaques within the arterial wall of medium...
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miR-146a contributes to atherosclerotic plaque stability by regulating the expression of TRAF6 and IRAK-1
BackgroundAtherosclerosis is a chronic inflammatory disease. The vulnerable plaque of atherosclerotic can lead to the development of many diseases...
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Atherogenic potential of microgravity hemodynamics in the carotid bifurcation: a numerical investigation
Long-duration spaceflight poses multiple hazards to human health, including physiological changes associated with microgravity. The hemodynamic...
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Impact of Probiotic Lactiplantibacillus plantarum ATCC 14917 on atherosclerotic plaque and its mechanism
Atherosclerosis is viewed as not just as a problem of lipid build-up in blood vessels, but also as a chronic inflammatory disease involving both...
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Unilateral Chronic Ischemia of the Carotid Bodies Alters Sympathetic Nervous System Activity
AbstractAs is well known, activation of carotid body chemoreceptors that sense arterial blood oxygen can lead to sympathetic nervous system (SNS)...
