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Role of Titin Phosphorylation in Myocardial Stiffness Changes during Cardiomyopathies
AbstractThe review provides a brief analysis of the current knowledge of such a post-translational modification of titin as phosphorylation, with a...
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Titin governs myocardial passive stiffness with major support from microtubules and actin and the extracellular matrix
Myocardial passive stiffness is crucial for the heart’s pump function and is determined by mechanical elements, including the extracellular matrix...
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N-terminal titin fragment: a non-invasive, pharmacodynamic biomarker for microdystrophin efficacy
BackgroundMultiple clinical trials to assess the efficacy of AAV-directed gene transfer in participants with Duchenne muscular dystrophy (DMD) are...
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Differential Expression of Titin and Obscurin mRNA in Striated Muscles of the Long-Tailed Ground Squirrel Urocitellus undulatus
AbstractSeasonal changes in mRNA levels of the giant sarcomeric cytoskeletal proteins titin and obscurin were studied in the skeletal m....
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High-proportion spliced-in titin truncating variants in African and European ancestry in the All of Us Research Program
High-proportion spliced-in titin truncating variants (hiPSI TTNtvs) have been associated with an increased risk of atrial fibrillation, dilated...
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The titin N2B and N2A regions: biomechanical and metabolic signaling hubs in cross-striated muscles
Muscle specific signaling has been shown to originate from myofilaments and their associated cellular structures, including the sarcomeres,...
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Alternative Splicing of Titin mRNA in Rat Soleus after Seven-Day Gravitational Unloading
AbstractChanges in titin alternative splicing in the rat soleus after seven-day gravitational unloading (the hindlimb unloading model) were studied...
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Molecular and cellular evidence for the impact of a hypertrophic cardiomyopathy-associated RAF1 variant on the structure and function of contractile machinery in bioartificial cardiac tissues
Noonan syndrome (NS), the most common among RASopathies, is caused by germline variants in genes encoding components of the RAS-MAPK pathway....
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Cardiac sarcomere mechanics in health and disease
The sarcomere is the fundamental structural and functional unit of striated muscle and is directly responsible for most of its mechanical properties....
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α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure
The sarcomeric interaction of α-myosin heavy chain (α-MHC) with Titin is vital for cardiac structure and contraction. However, the mechanism...
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Cardiac Mechanoperception and Mechanotransduction: Mechanisms of Stretch Sensing in Cardiomyocytes and Implications for Cardiomyopathy
The precise mechanisms, how (1) cardiomyocytes sense information about mechanical load and cellular stretch and strain and how (2) downstream signal...
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Cryo-electron tomography of intact cardiac muscle reveals myosin binding protein-C linking myosin and actin filaments
Myosin binding protein C (MyBP-C) is an accessory protein of the thick filament in vertebrate cardiac muscle arranged over 9 stripes of intervals of...
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Sex-specific cardiovascular remodeling leads to a divergent sex-dependent development of heart failure in aged hypertensive rats
IntroductionThe prevalence of heart failure with preserved ejection fraction (HFpEF) is continuously rising and predominantly affects older women...
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Human Stem Cell-Derived Cardiac Organoid-Like Structures: Generation and Applications
Since 2017, the interest in cardiac organoids has flourished. Their critical benefit relies on the three-dimensional organization and multicellular...
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Mechanobiology of Cardiac Remodelling in Cardiomyopathy
The contractile tissue of the heart is characterised by an exquisitely regular arrangement at the cellular and subcellular level. This ensures...
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ANKRD1 expression is aberrantly upregulated in the mdm mouse model of muscular dystrophy and induced by stretch through NFκB
The muscular dystrophy with myositis ( mdm) mouse model results in a severe muscular dystrophy due to an 83-amino-acid deletion in the N2A region of...
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The Molecular Basis of the Frank-Starling Law of the Heart: A Possible Role for PIEZO1?
The Frank-Starling Law was proposed over 100 years ago, but it remains to be fully explained at the molecular level. The Law states that when the...
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A transcriptional enhancer regulates cardiac maturation
Cardiomyocyte maturation is crucial for generating adult cardiomyocytes and the application of human pluripotent stem cell-derived cardiomyocytes...
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Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy
Alterations of serine/threonine phosphorylation of the cardiac proteome are a hallmark of heart failure. However, the contribution of tyrosine...
