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Associations between PBMC whole genome transcriptome, muscle strength, muscle mass, and physical performance in healthy home-dwelling older women
Increasing age is accompanied by many changes, including declining functional skeletal muscle health and immune dysfunction. Peripheral blood...
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Identification of co-expressed genes and immune infiltration features related to the progression of atherosclerosis
Atherosclerosis is a chronic inflammatory disease that affects arterial walls and is a leading cause of cardiovascular disease. Gene co-expression...
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SFXN3 is a Prognostic Marker and Promotes the Growth of Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a heterogeneous disease with rapid progression and frequent mutations. Sideroflexin3 (SFXN3) has been shown to be...
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Prognostic analysis of uveal melanoma based on the characteristic genes of M2-type macrophages in the tumor microenvironment
Uveal melanoma arises from stromal melanocytes and is the most prevalent primary intraocular tumor in adults. It poses a significant diagnostic and...
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Discovery of core genes and intercellular communication role in osteosarcoma
Osteosarcoma is a primary malignant bone tumor that affects children and young adults. Understanding the molecular mechanisms underlying osteosarcoma...
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Identification and validation of biomarkers related to lipid metabolism in osteoarthritis based on machine learning algorithms
BackgroundOsteoarthritis and lipid metabolism are strongly associated, although the precise targets and regulatory mechanisms are unknown.
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Comprehensive analysis revealed the immunoinflammatory targets of rheumatoid arthritis based on intestinal flora, miRNA, transcription factors, and RNA-binding proteins databases, GSEA and GSVA pathway observations, and immunoinfiltration ty**
ObjectiveRheumatoid arthritis (RA) is a chronic inflammatory arthritis. This study aimed to identify potential biomarkers and possible pathogenesis...
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The identification of signature genes and their relationship with immune cell infiltration in age-related macular degeneration
BackgroundAge-related macular degeneration (AMD) is a prevalent source of visual impairment among the elderly population, and its incidence has risen...
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A novel mitochondria-related gene signature in esophageal carcinoma: prognostic, immune, and therapeutic features
Esophageal carcinoma (ESCA) is a common and lethal malignant tumor worldwide. The mitochondrial biomarkers were useful in finding significant...
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Machine learning-based mRNA signature in early acute myocardial infarction patients: the perspective toward immunological, predictive, and personalized
Patients diagnosed with stable coronary artery disease (CAD) are at continued risk of experiencing acute myocardial infarction (AMI). This study aims...
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Construction of a m5C-related long non-coding RNA signature for the prognosis of hepatocellular carcinoma
RNA modification serves as a kind of posttranscriptional modification. Besides N6-methyladenosine (m6A), 5-methylcytosine(m5C) is also an important...
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Identification of lipid metabolism-related biomarkers for diagnosis and molecular classification of atherosclerosis
BackgroundAtherosclerosis is now the main cause of cardiac-cerebral vascular diseases around the world. Disturbances in lipid metabolism have an...
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Constructing ferroptosis-related competing endogenous RNA networks and exploring potential biomarkers correlated with immune infiltration cells in asthma using combinative bioinformatics strategy
BackgroundAsthma is a common chronic respiratory disease worldwide. Recent studies have revealed the critical effects of the ceRNA network and...
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Identification of immune-related lncRNA in sepsis by construction of ceRNA network and integrating bioinformatic analysis
BackgroundSepsis is a high mortality disease which seriously threatens human life and health, for which the pathogenetic mechanism still unclear....
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Construction of a novel pyrotosis-related prognostic model of esophageal square cell carcinoma and determination of the anti-tumor effect of WFDC12
Esophageal squamous cell carcinoma (ESCC) is a prevalent cancer type with a poor prognosis. As a form of programmed cell death, pyroptosis has been...
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Reduced Proteolipid Protein 2 promotes endoplasmic reticulum stress-related apoptosis and increases drug sensitivity in acute myeloid leukemia
BackgroundThe Proteolipid Protein 2 (PLP2), a protein in the Endoplasmic Reticulum (ER) membrane, has been reported to be highly expressed in various...
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Integrated analysis of single-cell and bulk RNA sequencing data identifies the characteristics of ferroptosis in lumbar disc herniation
Lumbar disc herniation (LDH) is the most common condition associated with low back pain, and it adversely impacts individuals’ health. Ferroptosis...
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A robust immune-related gene pairs signature for predicting the overall survival of esophageal cancer
BackgroundIdentifying reliable biomarkers could effectively predict esophagus carcinoma (EC) patients with poor prognosis. In this work, we...
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Construction and validation of a cuproptosis-related diagnostic gene signature for atrial fibrillation based on ensemble learning
BackgroundAtrial fibrillation (AF) is the most common type of cardiac arrhythmia. Nonetheless, the accurate diagnosis of this condition continues to...
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Identification of mitophagy-related biomarkers and immune infiltration in major depressive disorder
BackgroundMajor depressive disorder (MDD) is a life-threatening and debilitating mental health condition. Mitophagy, a form of selective autophagy...
