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Hesperidin ameliorates H2O2-induced bovine mammary epithelial cell oxidative stress via the Nrf2 signaling pathway
BackgroundHesperidin is a citrus flavonoid with anti-inflammatory and antioxidant potential. However, its protective effects on bovine mammary...
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Successful editing and maintenance of lactogenic gene expression in primary bovine mammary epithelial cells
In vitro investigation of bovine lactation processes is limited by a lack of physiologically representative cell models. This deficiency is most...
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miRNA-214-3p stimulates carcinogen-induced mammary epithelial cell apoptosis in mammary cancer-resistant species
Mammary cancer incidence varies greatly across species and underlying mechanisms remain elusive. We previously showed that mammosphere-derived...
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Lithium Chloride Promotes Endogenous Synthesis of CLA in Bovine Mammary Epithelial Cells
Although conjugated linoleic acid (CLA) can promote human health, its content in milk is insufficient to have a significant impact. The majority of...
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Evaluation of the Epithelial Barrier Integrity in Primary Cultures of Pig Mammary Epithelial Cells
A major feature of epithelial and endothelial cells is the creation of biological barriers able to protect the body against stressors that could...
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Resveratrol inhibits LPS-induced apoptosis in bovine mammary epithelial cells: the role of PGC1α-SIRT3 axis
Resveratrol (Res) is a bioactive dietary component and alleviates apoptosis in multiple cell types. However, its effect and mechanism on...
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SIM2s directed Parkin-mediated mitophagy promotes mammary epithelial cell differentiation
The functionally differentiated mammary gland adapts to extreme levels of stress from increased demand for energy by activating specific protective...
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SNAT2-mediated regulation of estrogen and progesterone in the proliferation of goat mammary epithelial cells
The development of the goat mammary gland is mainly under the control of ovarian hormones particularly estrogen and progesterone (P 4 ). Amino acids...
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Targeting canine mammary neoplastic epithelial cells with a reengineered anthrax toxin: first study
Mammary tumors are the most frequent type of neoplasms in intact female dogs. New therapies that target neoplastic cells without affecting normal...
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Depletion of serum-derived exosomes aggravates heat stress-induced damage of bovine mammary epithelial cells
BackgroundExosomes are involved in intercellular communication, affecting many physiological and pathological process. The present study evaluated...
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Fibroblast-Epithelium Co-culture Methods Using Epithelial Organoids and Cell Line–Derived Spheroids
Fibroblasts are an integral cell type of mammary gland stroma, which plays crucial roles in development, homeostasis, and tumorigenesis of mammary...
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Selenomethionine Inhibits NF-κB-mediated Inflammatory Responses of Bovine Mammary Epithelial Cells Caused by Klebsiella pneumoniae by Increasing Autophagic Flux
Klebsiella pneumoniae ( K. pneumoniae ) is one of the major pathogens causing bovine clinical mastitis. Autophagy maintains cellular homeostasis and...
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The effect of bta-miR-1296 on the proliferation and extracellular matrix synthesis of bovine mammary fibroblasts
Mammary fibrosis in dairy cows is a chronic condition caused by mastitis, and can lead to serious culling of dairy cows resulting in huge economic...
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The alteration of N6-methyladenosine (m6A) modification at the transcriptome-wide level in response of heat stress in bovine mammary epithelial cells
BackgroundHeat stress has a substantial negative economic impact on the dairy industry. N6-methyladenosine (m6A) is the most common internal RNA...
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Inhibiting nuclear factor erythroid 2 related factor 2-mediated autophagy in bovine mammary epithelial cells induces oxidative stress in response to exogenous fatty acids
BackgroundIn early lactation, bovine mammary epithelial cells undergo serious metabolic challenges and oxidative stress both of which could be...
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Sprouty genes regulate activated fibroblasts in mammary epithelial development and breast cancer
Stromal fibroblasts are a major stem cell niche component essential for organ formation and cancer development. Fibroblast heterogeneity, as revealed...
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Punch-excised explants of bovine mammary gland to model early immune response to infection
BackgroundMammary gland (MG) infections (mastitis) are frequent diseases of dairy cows that affect milk quality, animal welfare and farming...
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Fatty acid amide hydrolase drives adult mammary gland development by promoting luminal cell differentiation
Mammary gland development occurs primarily in adulthood, undergoing extensive expansion during puberty followed by cycles of functional...
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SIRT3 protects bovine mammary epithelial cells from heat stress damage by activating the AMPK signaling pathway
With global warming, heat stress has become an important challenge for the global dairy industry. Sirtuin 3 (SIRT3), an important mitochondrial...
