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Adding intrinsically disordered proteins to biological ageing clocks
Research into how the young and old differ, and which biomarkers reflect the diverse biological processes underlying ageing, is a current and...
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The influence of biological sex in human skeletal muscle transcriptome during ageing
Sex is a crucial biological variable, and influence of biological sex on the change of gene expression in ageing skeletal muscle has not yet been...
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The duration of lithium use and biological ageing: telomere length, frailty, metabolomic age and all-cause mortality
Lithium is an established first-line treatment for bipolar disorder. Beyond its therapeutic effect as a mood stabiliser, lithium exhibits potential...
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Combined aerobic and strength exercise training on biological ageing in Singaporean breast cancer patients: protocol for the Breast Cancer Exercise Intervention (BREXINT) Pilot Study
Breast cancer (BC) is the most prominent cancer amongst women, but fortunately, early diagnosis and advances in multimodality treatments have...
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Measuring healthy ageing: current and future tools
Human ageing is a complex, multifactorial process characterised by physiological damage, increased risk of age-related diseases and inevitable...
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Adipose tissue as a linchpin of organismal ageing
Ageing is a conserved biological process, modulated by intrinsic and extrinsic factors, that leads to changes in life expectancy. In humans, ageing...
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A commentary on studies of brain iron accumulation during ageing
Brain iron content is widely reported to increase during “ageing”, across multiple species from nematodes, rodents (mice and rats) and humans. Given...
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Dynamic lipidome alterations associated with human health, disease and ageing
Lipids can be of endogenous or exogenous origin and affect diverse biological functions, including cell membrane maintenance, energy management and...
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Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume
The concept of age acceleration, the difference between biological age and chronological age, is of growing interest, particularly with respect to...
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Association between cardiovascular health metrics and retinal ageing
The study aims to investigate associations between cardiovascular health (CVH) metrics and retinal ageing indexed by retinal age gap. A total of...
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Molecular hallmarks of ageing in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal, severely debilitating and rapidly progressing disorder affecting motor neurons in the brain,...
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The rosetta stone of successful ageing: does oral health have a role?
Ageing is an inevitable aspect of life and thus successful ageing is an important focus of recent scientific efforts. The biological process of...
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A comprehensive model for the biochemistry of ageing, senescence and longevity
Various models for ageing, each focussing on different biochemical and/or cellular pathways have been proposed. This has resulted in a complex and...
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SIRT4 in ageing
Ageing is a phenomenon in which cells, tissues and organs undergo systemic pathological changes as individuals age, leading to the occurrence of...
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Glycan clock of ageing—analytical precision and time-dependent inter- and i-individual variability
Ageing is a complex biological process with variations among individuals, leading to the development of ageing clocks to estimate biological age....
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Ageing as a software design flaw
Ageing is inherent to all human beings, yet why we age remains a hotly contested topic. Most mechanistic explanations of ageing posit that ageing is...
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Self-rated health, epigenetic ageing, and long-term mortality in older Australians
Self-rated health (SRH) is a subjective indicator of overall health based on a single questionnaire item. Previous evidence found that it is a strong...
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Yeast as a model for ageing and apoptosis research
Apoptosis is a form of programmed cell death with a crucial role in health and disease in metazoans. Recent findings demonstrate the existence of an...
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Accelerated ageing and coronary microvascular dysfunction in chronic heart failure in Tgαq*44 mice
Age represents a major risk factor in heart failure (HF). However, the mechanisms linking ageing and HF are not clear. We aimed to identify the...
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Exploring the ageing methylome in the model insect, Nasonia vitripennis
BackgroundThe ageing process is a multifaceted phenomenon marked by the gradual deterioration of cellular and organismal functions, accompanied by an...
