Search
Search Results
-
Human umbilical cord-derived mesenchymal stem cells ameliorate perioperative neurocognitive disorder by inhibiting inflammatory responses and activating BDNF/TrkB/CREB signaling pathway in aged mice
BackgroundPerioperative neurocognitive disorder (PND) is a key complication affecting older individuals after anesthesia and surgery. Failure to...
-
Activation of TrkB signaling mitigates cerebellar anomalies caused by Rbm4-Bdnf deficiency
A molecular and functional link between neurotrophin signaling and cerebellar foliation is lacking. Here we show that constitutive knockout of two...
-
Effects of Excessive Iodine on the BDNF-TrkB Signaling Pathway and Related Genes in Offspring of EAT Rats
Excess iodine can cause autoimmune thyroiditis (AIT) in women, but it is unclear whether this has any implications for neurodevelopmental mechanisms...
-
Increased levels and activation of the IL-17 receptor in microglia contribute to enhanced neuroinflammation in cerebellum of hyperammonemic rats
BackgroundPatients with liver cirrhosis may show minimal hepatic encephalopathy (MHE) with mild cognitive impairment and motor incoordination. Rats...
-
STAT3–BDNF–TrkB signalling promotes alveolar epithelial regeneration after lung injury
Alveolar epithelial regeneration is essential for recovery from devastating lung diseases. This process occurs when type II alveolar pneumocytes (AT2...
-
Exertional heat stroke-induced changes in gut microbiota cause cognitive impairment in mice
BackgroundThe incidence of exertional heat stroke (EHS) escalates during periods of elevated temperatures, potentially leading to persistent...
-
A rare olive compound oleacein functions as a TrkB agonist and mitigates neuroinflammation both in vitro and in vivo
BackgroundNeuroinflammation is widely acknowledged as a characteristic feature of almost all neurological disorders and specifically in depression-...
-
Comprehensive characterization of the neurogenic and neuroprotective action of a novel TrkB agonist using mouse and human stem cell models of Alzheimer’s disease
BackgroundNeural stem cell (NSC) proliferation and differentiation in the mammalian brain decreases to minimal levels postnatally. Nevertheless,...
-
Repetitive transcranial magnetic stimulation ameliorates cognitive deficits in mice with radiation-induced brain injury by attenuating microglial pyroptosis and promoting neurogenesis via BDNF pathway
BackgroundRadiation-induced brain injury (RIBI) is a common and severe complication during radiotherapy for head and neck tumor. Repetitive...
-
Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy
Astrocytes have emerged as crucial regulators of neuronal network activity, synapse formation, and underlying behavioral and cognitive processes....
-
Biochemical Mechanisms of Beneficial Effects of Beta-Alanine Supplements on Cognition
AbstractUsing nutritional interventions to cure and manage psychiatric disorders is a promising tool. In this regard, accumulating documents support...
-
Oxidative stress in Alzheimer’s disease: current knowledge of signaling pathways and therapeutics
Alzheimer’s disease’s pathophysiology is still a conundrum. Growing number of evidences have elucidated the involvement of oxidative stress in the...
-
Interaction of aerobic exercise and crocin improves memory, learning and hypocampic tau and neurotrophins gene expression in rats treated with trimethytin as a model of Alzheimer’s disease
IntroductionAlzheimer’s disease (AD) is characterized by progressive cognitive decline and a reduction in hippocampal neurotrophins, in which...
-
BDNF Prodomain Inhibits Neurotransmitter Quantal Release in Mouse Motor Synapses with the Necessary Participation of Sortilin and Adenosine A1-Receptors
AbstractBrain neurotrophin (BDNF) is synthesized by proteolysis of proneurotrophin to form mature BDNF and the prodomain, whose regulatory activity...
-
Clathrin-nanoparticles deliver BDNF to hippocampus and enhance neurogenesis, synaptogenesis and cognition in HIV/neuroAIDS mouse model
Brain derived neurotrophic factor (BDNF) promotes the growth, differentiation, maintenance and survival of neurons. These attributes make BDNF a...
-
The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders
Sonic hedgehog (Shh) signaling is an essential central nervous system (CNS) pathway involved during embryonic development and later life stages....
-
Human Wharton’s Jelly Mesenchymal Stem Cell Secretome Modifies the Processes of Neuroprotection and Epithelial-Mesenchymal Transition in Retinal Pigment Epithelium at Transcriptional Level
BackgroundRetinal pigment epithelium (RPE) cells are potential targets for treating retinal detachment (RD) and proliferative vitreoretinopathy...
-
The implication of ciliary signaling pathways for epithelial–mesenchymal transition
Epithelial-to-mesenchymal transition (EMT), which plays an essential role in development, tissue repair and fibrosis, and cancer progression, is a...
-
Imbalance of Angiogenic and Growth Factors in Placenta in Maternal Hyperhomocysteinemia
AbstractNumerous studies have shown that various adverse factors of different nature and action mechanisms have similar negative influence on...
-
Melatonin antagonizes oxidative stress-induced apoptosis in retinal ganglion cells through activating the thioredoxin-1 pathway
This study aimed to explore the role of melatonin in oxidative stress-induced injury on retinal ganglion cells and the underlying mechanisms. The...
