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Identification and Genomic Localization of Autosomal sdY Locus in a Population of Atlantic Salmon (Salmo salar)
The determination of sex in salmonid fishes is controlled by genetic mechanisms, with males being the heterogametic sex. The master sex-determining...
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Radiation Biology of Structurally Different Drosophila melanogaster Genes: Report 9. General Regularities and Locus-Specific Features of Radiomutability of Sex-Linked and Autosomal Genes
AbstractThe results of large-scale radiation, genetic, cytogenetic, and molecular genetic studies on the nature and frequency of heritable mutations...
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Evaluation of the Autosomal STR Markers and Kits
DNA profiling is one of the most important and ultimate techniques for identification of the individuals, biological dispute, family history,...
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A novel missense mutation in the CRYBA2 caused autosomal dominant presenile cataract in a Chinese family
Presenile cataract is a relatively rare type of cataract, but its genetic mechanisms are currently not well understood. The precise identification of...
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A genetic locus complements resistance to Bordetella pertussis-induced histamine sensitization
Histamine plays pivotal role in normal physiology and dysregulated production of histamine or signaling through histamine receptors (HRH) can promote...
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Autosomal recessive inheritance of a novel missense mutation of ITGB4 for Epidermolysis-Bullosa pyloric-atresia: a case report
Epidermolysis-Bullosa (EB), a rare Mendelian disorder, exhibits complex phenotypic and locus-heterogeneity. We identified a nuclear family of...
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Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus
Identifying genetic determinants of reproductive success may highlight mechanisms underlying fertility and identify alleles under present-day...
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A genome-wide association study identifies a locus associated with knee extension strength in older Japanese individuals
Sarcopenia is a common skeletal muscle disease in older people. Lower limb muscle strength is a good predictive value for sarcopenia; however, little...
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Disruption of the Uty epigenetic regulator locus in hematopoietic cells phenocopies the profibrotic attributes of Y chromosome loss in heart failure
Heart failure affects millions of people worldwide, with men exhibiting a higher incidence than women. Our previous work has shown that mosaic loss...
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Duplication, recombination and weak selection shape evolution at the MHC class II SLA-DRB1 locus in wild boars from the western Balkans
The Eurasian wild boar ( Sus scrofa ), having faced a population size reduction during the nineteenth and early twentieth centuries, is now...
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An autosomal recessive variant in PYGM causes myophosphorylase deficiency in Red Angus composite cattle
BackgroundBetween 2020 and 2022, eight calves in a Nebraska herd (composite Simmental, Red Angus, Gelbvieh) displayed exercise intolerance during...
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Determination of allele frequencies in 15 autosomal short tandem repeat (STR) loci of Arab residents in Iraq
Recent advances in genetic research and molecular techniques have significantly contributed to our understanding of human population genetics and its...
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Molecular genetics, neuroimaging outcomes, and structural analyses of novel and recurrent variants of WDR62 gene in two consanguineous Pakistani families with autosomal recessive primary microcephaly
BackgroundAutosomal recessive primary microcephaly (MCPH) is a rare neurodevelopmental and genetically heterogeneous disorder, characterized by small...
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Curated variation benchmarks for challenging medically relevant autosomal genes
The repetitive nature and complexity of some medically relevant genes poses a challenge for their accurate analysis in a clinical setting. The Genome...
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Y chromosomal noncoding RNAs regulate autosomal gene expression via piRNAs in mouse testis
BackgroundDeciphering the functions of Y chromosome in mammals has been slow owing to the presence of repeats. Some of these repeats transcribe...
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Spatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition
Autopsy studies indicated that the locus coeruleus (LC) accumulates hyperphosphorylated tau before allocortical regions in Alzheimer’s disease. By...
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Map** intron retention events contributing to complex traits using splice quantitative trait locus
BackgroundAlternative splicing (AS) of mRNA plays an important roles in transcriptome diversity, involving regulation of plant growth and stress...
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Investigating the interaction between inter-locus and intra-locus sexual conflict using hemiclonal analysis in Drosophila melanogaster
BackgroundDivergence in the evolutionary interests of males and females leads to sexual conflict. Traditionally, sexual conflict has been classified...
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Evaluation of the Autosomal STR Markers and Kits
DNA profiling is one of the most important and ultimate techniques for identification of the individuals, biological dispute, family history,...
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Genetic analysis based on 15 autosomal short tandem repeats (STRs) in the Chaouia population, western center Morocco, and genetic relationships with worldwide populations
The complex demographic history of human populations in North Africa has resulted in a high degree of genetic heterogeneity across the region....
