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Protective effect of SERCA2a-SUMOylation by SUMO-1 on diabetes-induced atherosclerosis and aortic vascular injury
AbstractDiabetes is a major risk factor for cardiovascular disease. However, the exact mechanism by which diabetes contributes to vascular damage is...
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3,4-dimethoxychalcone induces autophagy and reduces neointimal hyperplasia and aortic lesions in mouse models of atherosclerosis
Autophagy inducers can prevent cardiovascular aging and age-associated diseases including atherosclerosis. Therefore, we hypothesized that...
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DNA Methylation Profiling in Aneurysm and Comorbid Atherosclerosis of the Ascending Aorta
AbstractAtherosclerosis and aneurysm of the aorta are relatively common pathological conditions that remain asymptomatic for a long period of time...
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TREM2 promotes cholesterol uptake and foam cell formation in atherosclerosis
Disordered lipid accumulation in the arterial wall is a hallmark of atherosclerosis. Previous studies found that the expression of triggering...
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Atherosclerosis antigens as targets for immunotherapy
Atherosclerosis is a chronic inflammatory disease of the arteries that can lead to thrombosis, infarction and stroke, underlying the first cause of...
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Macrophage polarization and metabolism in atherosclerosis
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of fatty deposits in the inner walls of vessels. These plaques...
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The role of CNPY2 in endothelial injury and inflammation during the progress of atherosclerosis
Vascular endothelial cells (VECs) injury is closely related to the occurrence and development of atherosclerosis. Canopy FGF signaling regulator 2...
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TREM2 protects from atherosclerosis by limiting necrotic core formation
Atherosclerosis is a chronic disease of the vascular wall driven by lipid accumulation and inflammation in the intimal layer of arteries, and its...
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PKCδ regulates the vascular biology in diabetic atherosclerosis
Diabetes mellitus, known for its complications, especially vascular complications, is becoming a globally serious social problem. Atherosclerosis has...
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Adropin inhibits the progression of atherosclerosis in ApoE-/-/Enho-/- mice by regulating endothelial-to-mesenchymal transition
Adropin, a secreted protein, coded by energy homeostasis-associated gene (Enho), is recently reported to modulate atherogenesis, with...
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Functional role of Ash2l in oxLDL induced endothelial dysfunction and atherosclerosis
Endothelial injury and dysfunction in the artery wall fuel the process of atherosclerosis. As a key epigenetic regulator, Ash2l (Absent, small, or...
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Nobiletin alleviates atherosclerosis by inhibiting lipid uptake via the PPARG/CD36 pathway
BackgroundAtherosclerosis (AS) is a persistent inflammatory condition triggered and exacerbated by several factors including lipid accumulation,...
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Noncoding RNAs in atherosclerosis: regulation and therapeutic potential
Atherosclerosis, a chronic disease of arteries, results in high mortality worldwide as the leading cause of cardiovascular disease. The development...
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Trem2 promotes foamy macrophage lipid uptake and survival in atherosclerosis
Atherosclerosis is driven by the expansion of cholesterol-loaded ‘foamy’ macrophages in the arterial intima. Factors regulating foamy macrophage...
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Enhanced tyrosine sulfation is associated with chronic kidney disease-related atherosclerosis
BackgroundChronic kidney disease (CKD) accelerates atherosclerosis, but the mechanisms remain unclear. Tyrosine sulfation has been recognized as a...
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Therapeutic efficacies of mitochondria-targeted esculetin and metformin in the improvement of age-associated atherosclerosis via regulating AMPK activation
Atherosclerosis, in general, is an age-associated cardiovascular disease wherein a progressive decline in mitochondrial function due to aging majorly...
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Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities
Accumulating evidence over the past decades has revealed an intricate relationship between dysregulation of cellular metabolism and the progression...
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DNA methylation and histone post-translational modifications in atherosclerosis and a novel perspective for epigenetic therapy
Atherosclerosis, which is a vascular pathology characterized by inflammation and plaque build-up within arterial vessel walls, acts as the important...
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Identification of a non-canonical chemokine-receptor pathway suppressing regulatory T cells to drive atherosclerosis
CCL17 is produced by conventional dendritic cells, signals through CCR4 on regulatory T (T reg ) cells and drives atherosclerosis by suppressing T reg ...
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DIAPH1 mediates progression of atherosclerosis and regulates hepatic lipid metabolism in mice
Atherosclerosis evolves through dysregulated lipid metabolism interwoven with exaggerated inflammation. Previous work implicating the receptor for...
