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Production and use of antigen tetramers to study antigen-specific B cells
B cells generate antibodies that provide protection from infection, but also cause pathology in autoimmune and allergic conditions. Antigen-specific...
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Recreation of an antigen-driven germinal center in vitro by providing B cells with phagocytic antigen
Successful vaccines rely on activating a functional humoral immune response through the generation of class-switched high affinity immunoglobulins...
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Sequence-Based Nanobody-Antigen Binding Prediction
Nanobodies (Nb) are monomeric heavy-chain fragments derived from heavy-chain only antibodies naturally found in Camelids and Sharks. Their...
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CyTOF Intracellular Cytokine Assays for Antigen-Specific T Cells
T cells specific for a single antigen tend to be rare, even after expansion of memory cells. They are commonly detected by in vitro stimulation with...
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Neutrophils Are Atypical Antigen-Presenting Cells
AbstractNeutrophils are the most numerous blood leukocytes and are the “first line” of defense against pathogens in the focus of inflammation, where...
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Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy
Dendritic cells (DCs) are antigen-presenting myeloid cells that regulate T cell activation, trafficking and function. Monocyte-derived DCs pulsed...
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Antigen-Specific Immunotherapy for Allergic and Autoimmune Diseases Using Plant-Made Antigens
Antigen-specific immunotherapy (AIT) is the only available potentially curative treatment that targets the cause of allergic or autoimmune diseases....
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Extracellular domains of CARs reprogramme T cell metabolism without antigen stimulation
Metabolism is an indispensable part of T cell proliferation, activation and exhaustion, yet the metabolism of chimeric antigen receptor (CAR)-T cells...
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Extract antibody and antigen names from biomedical literature
BackgroundThe roles of antibody and antigen are indispensable in targeted diagnosis, therapy, and biomedical discovery. On top of that, massive...
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Identification and Characterization of Antigen-Specific T-Cells in Viral Infections
Identification and characterization of CD8+ T-cells is important to determine their role in protecting and clearing viral infections. Here we provide...
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Methods of Machine Learning-Based Chimeric Antigen Receptor Immunological Synapse Quality Quantification
Chimeric Antigen Receptor (CAR)-mediated immunotherapy shows promising results for refractory blood cancers. Currently, six CAR-T drugs have been...
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DG-Affinity: predicting antigen–antibody affinity with language models from sequences
BackgroundAntibody-mediated immune responses play a crucial role in the immune defense of human body. The evolution of bioengineering has led the...
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Lipopolysaccharide O-antigen profiles of Helicobacter pylori strains from Southwest China
BackgroundHelicobacter pylori lipopolysaccharide (LPS) structures vary among strains of different geographic origin. The aim of this study was to...
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The potential oncogenic effect of tissue-specific expression of JC polyoma T antigen in digestive epithelial cells
JC polyoma virus (JCPyV), a ubiquitous polyoma virus that commonly infects people, is identified as the etiologic factor for progressive multifocal...
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LncRNA Neat1 targets NonO and miR-128-3p to promote antigen-specific Th17 cell responses and autoimmune inflammation
Long non-coding RNAs (lncRNAs) interaction with RNA-Binding proteins (RBPs) plays an important role in immunological processes. The generation of...
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Two-dimensional high-throughput on-cell screening of immunoglobulins against broad antigen repertoires
Identifying high-affinity antibodies in human serum is challenging due to extremely low number of circulating B cells specific to the desired...
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Zebularine potentiates anti-tumor immunity by inducing tumor immunogenicity and improving antigen processing through cGAS-STING pathway
DNA methylation is an important epigenetic mechanism involved in the anti-tumor immune response, and DNA methyltransferase inhibitors (DNMTi) have...
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Synergistic effect of chimeric antigen receptor modified with Bcl-2 on enhanced solid tumour targeting
Engineered T cells expressing chimeric antigen receptors (CARs) have shown remarkable therapeutic effects on haematological malignancies. However,...
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Swarna Bhasma Induces Antigen-Presenting Abilities of Macrophages and Helps Antigen Experienced CD4+ T Cells to Acquire Th1 Phenotypes Against Leishmania donovani Antigens
In leishmaniasis, the protective immunity is largely mediated by proinflammatory cytokine producing abilities of T cells and an efficient parasite...
