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PEBP4 deficiency aggravates LPS-induced acute lung injury and alveolar fluid clearance impairment via modulating PI3K/AKT signaling pathway
Acute lung injury (ALI) is a common clinical syndrome, which often results in pulmonary edema and respiratory distress. It has been recently reported...
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TRAF6-mediated ubiquitination of AKT in the nucleus is a critical event underlying the desensitization of G protein-coupled receptors
BackgroundDesensitization of G protein–coupled receptors (GPCRs) refers to the attenuation of receptor responsiveness by prolonged or intermittent...
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An in silico approach to identify novel and potential Akt1 (protein kinase B-alpha) inhibitors as anticancer drugs
Akt1 (protein kinase B) has become a major focus of attention due to its significant functionality in a variety of cellular processes and the...
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The interplay of PTEN and AKT nexus in breast cancer: a molecular perspective
BackgroundBreast cancer is a highly prevalent and life-threatening ailment that is commonly detected among the females. The downregulation of PTEN ...
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Amphiregulin regulates odontogenic differentiation of dental pulp stem cells by activation of mitogen-activated protein kinase and the phosphatidylinositol 3-kinase signaling pathways
BackgroundHuman dental pulp stem cells (hDPSCs) have received widespread attention in the fields of tissue engineering and regenerative medicine....
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The role of the PI3K/AKT signalling pathway in the corneal epithelium: recent updates
Phosphatidylinositol 3 kinase (PI3K)/AKT (also called protein kinase B, PKB) signalling regulates various cellular processes, such as apoptosis, cell...
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Aging: silencing the PKA and AkT/PKB signaling pathways alters the antioxidant capacity of resveratrol
One of the theories related to aging is the increase in oxidative stress. Given this, the objective of the study is to evaluate the cellular...
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RIP3 orchestrates oxidative stress and pyroptosis in doxorubicin-induced cardiotoxicity through regulation of AKT/Nrf2 signaling cascade
This study was designed to explore the role of RIP3 in DOX-induced cardiotoxicity and its underlying molecular mechanisms. Our results demonstrate...
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Ilicicolin C suppresses the progression of prostate cancer by inhibiting PI3K/AKT/mTOR pathway
Aberrant activation of the PI3K/AKT pathway is a driving factor in the development of prostate cancer. Therefore, inhibiting the function of the...
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Structure–function relationship and physiological role of apelin and its G protein coupled receptor
Apelin receptor (APJR) is a class A peptide (apelin) binding G protein-coupled receptor (GPCR) that plays a significant role in regulating blood...
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Regorafenib induces Bim-mediated intrinsic apoptosis by blocking AKT-mediated FOXO3a nuclear export
Regorafenib (REGO) is a synthetic oral multi-kinase inhibitor with potent antitumor activity. In this study, we investigate the molecular mechanisms...
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Dietary L-arginine supplementation increases the hepatic expression of AMP-activated protein kinase in rats
The goal of this study was to elucidate the molecular mechanisms responsible for the anti-obesity effect of L-arginine supplementation in...
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RNF12 is regulated by AKT phosphorylation and promotes TGF-β driven breast cancer metastasis
Transforming growth factor-β (TGF-β) acts as a pro-metastatic factor in advanced breast cancer. RNF12, an E3 ubiquitin ligase, stimulates TGF-β...
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FKBP51 plays an essential role in Akt ubiquitination that requires Hsp90 and PHLPP
FKBP51 plays a relevant role in sustaining cancer cells, particularly melanoma. This cochaperone participates in several signaling pathways. FKBP51...
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Inhibition of the ILK-AKT pathway by upregulation of PARVB contributes to the cochlear cell death in Fascin2 gene knockout mice
The Fscn2 ( Fascin2 ) gene encodes an actin cross-linking protein that is involved in the formation of hair cell stereocilia and retina structure....
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HMGB1 induces radioresistance through PI3K/AKT/ATM pathway in esophageal squamous cell carcinoma
BackgroundTo explore the effect of HMGB1 on the radio-sensitivity of esophageal cancer cells through regulating the PI3K/Akt/ATM pathway.
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Crocin alleviates neurotoxicity induced by bupivacaine in SH-SY5Y cells with inhibition of PI3K/AKT signaling
BackgroundBupivacaine, a common local anesthetic, can cause neurotoxicity and permanent neurological disorders. Crocin has been widely reported as a...
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K-Ras(V12) differentially affects the three Akt isoforms in lung and pancreatic carcinoma cells and upregulates E-cadherin and NCAM via Akt3
K-Ras is the most frequently mutated Ras variant in pancreatic, colon and non-small cell lung adenocarcinoma. Activating mutations in K-Ras result in...
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DNA repair protein DNA-PK protects PC12 cells from oxidative stress-induced apoptosis involving AKT phosphorylation
BackgroundEmerging evidence suggest that DNA-PK complex plays a role in the cellular response to oxidative stress, in addition to its function of...
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The Effects of Sodium Fluoride (NaF) Treatment on the PI3K/Akt Signal Pathway in NRK-52E Cells
The effects of the element fluorine on the phosphoinositide-3-kinase–protein kinase B/Akt (PI3K/Akt) pathway has a significant role in regulation of...
