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An intricate regulation of WblA controlling production of silent tylosin analogues and abolishment of expressible nikkomycin
Genome sequencing has revealed that actinomycetes possess the potential to produce many more secondary metabolites than previously thought. The...
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Dual regulation between the two-component system PhoRP and AdpA regulates antibiotic production in Streptomyces
Antibiotic production during secondary metabolism in Streptomyces spp. is elaborately controlled by multiple environmental signals and intracellular...
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Transcriptional regulators of secondary metabolite biosynthesis in Streptomyces
In the post-genome era, great progress has been made in metabolic engineering using recombinant DNA technology to enhance the production of...
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Exploring a general multi-pronged activation strategy for natural product discovery in Actinomycetes
Natural products possess significant therapeutic potential but remain underutilized despite advances in genomics and bioinformatics. While there are...
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Heterologous AdpA transcription factors enhance landomycin production in Streptomyces cyanogenus S136 under a broad range of growth conditions
Streptomyces cyanogenus S136 is the only known producer of landomycin A (LaA), one of the largest glycosylated angucycline antibiotics possessing...
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An integrative-omics analysis of an industrial clavulanic acid-overproducing Streptomyces clavuligerus
AbstractClavulanic acid (CA) is a clinically important secondary metabolite used to treat infectious diseases. We aimed to decipher complex...
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Genetic approaches to improve clorobiocin production in Streptomyces roseochromogenes NRRL 3504
Streptomyces roseochromogenes NRRL 3504 is best known as a producer of clorobiocin, a DNA replication inhibitor from the aminocoumarin family of...
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AdpAsd, a Positive Regulator for Morphological Development and Toyocamycin Biosynthesis in Streptomyces diastatochromogenes 1628
AdpA is studied and considered as a pleiotropic regulator which is involved in morphological development and secondary metabolism in many Streptomyces ...
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Regulation of Secondary Metabolites Through Signaling Molecules in Streptomyces
The bacterial genus Streptomyces is well characterized by an ability to produce a wide variety of secondary metabolites including antibiotics,...
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Genomic Insights into Evolution of AdpA Family Master Regulators of Morphological Differentiation and Secondary Metabolism in Streptomyces
The AdpA protein from a streptomycin producer Streptomyces griseus is a founding member of the AdpA family of pleiotropic regulators, known to be...
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Quorum Sensing and Quorum Quenching Metabolites in Actinomycetes
Quorum sensing or cell-to-cell communication in bacteria regulates gene expression and phenotype production based on population density. Basically,...
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AflQ1-Q2 represses lincomycin biosynthesis via multiple cascades in Streptomyces lincolnensis
AbstractLincomycin is a broad-spectrum antibiotic and particularly effective against Gram-positive pathogens. Albeit familiar with the biosynthetic...
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Applications of Microbes in Antibiotics
The discovery of antibiotics is one of the most successful therapies to ever occur in the history of medicine. They have saved millions of lives...
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Manipulation and epigenetic control of silent biosynthetic pathways in actinobacteria
Most biosynthetic gene clusters (BGCs) of Actinobacteria are either silent or expressed less than the detectable level. The non-genetic approaches...
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A novel strategy of gene screen based on multi-omics in Streptomyces roseosporus
AbstractDaptomycin is a new lipopeptide antibiotic for treatment of severe infection caused by multi-drug-resistant bacteria, but its production cost...
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Singlet Oxygen Quantum Yield Determination Using Chemical Acceptors
Singlet oxygen (1O2) is the first electronic excited state of molecular oxygen. Due to its non-radical and non-ionic character as well as its mild...
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Fine map** and validation of a major QTL for grain weight on chromosome 5B in bread wheat
Key messageA major QTL QTgw.caas-5B for thousand grain weight in wheat was fine mapped on chromosome 5B, and TraesCS5B02G044800 was predicted to be...
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Enhanced Tunicamycin Biosynthesis in BldG Overexpressed Streptomyces clavuligerus
AbstractTunicamycin is a nucleoside type antibiotic with a potent antibacterial activity. Tunicamycin gene cluster in Streptomyces clavuligerus ...
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DeoR regulates lincomycin production in Streptomyces lincolnensis
Regulators belonging to the DeoR family are widely distributed among the bacteria. Few studies have reported that DeoR family proteins regulate...
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Post-crotonylation oxidation by a monooxygenase promotes acetyl-CoA synthetase degradation in Streptomyces roseosporus
Protein post-translational modifications (PTMs) with various acyl groups play central roles in Streptomyces . But whether these acyl groups can be...
