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SIRT1 safeguards adipogenic differentiation by orchestrating anti-oxidative responses and suppressing cellular senescence
Adipose tissue is an important endocrine organ that regulates metabolism, immune response and aging in mammals. Healthy adipocytes promote tissue...
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Betaine regulates adipogenic and osteogenic differentiation of hAD-MSCs
BackgroundWith an ageing population, the incidence of bone loss and obesity are increasing. Numerous studies emphasized the multidirectional...
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Molecular and Cellular Mechanisms Governing Adipogenic Differentiation
AbstractAdipose tissue is a special type of connective tissue that comprises stromal-vascular cells, committed preadipocytes, and mature adipocytes....
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Isolation methods, proliferation, and adipogenic differentiation of adipose-derived stem cells from different fat depots in bovines
The adipose-derived stem cells (ASCs) are a valuable resource for regenerative medicine and essential materials for research in fat deposition....
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Targeted erasure of DNA methylation by TET3 drives adipogenic reprogramming and differentiation
DNA methylation is a crucial epigenetic modification in the establishment of cell-type-specific characteristics. However, how DNA methylation is...
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Aquaporin-7 Facilitates Proliferation and Adipogenic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Regulating Hydrogen Peroxide Transport
Hydrogen peroxide (H 2 O 2 ) is a major form of reactive oxygen species that play an important role in the survival, proliferation and differentiation of...
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Impairment of APPL1/Myoferlin facilitates adipogenic differentiation of mesenchymal stem cells by blocking autophagy flux in osteoporosis
An imbalance of human mesenchymal stem cells (hMSCs) adipogenic and osteogenic differentiation is crucial in the pathogenesis of osteoporosis, and...
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Kaempferia parviflora extract and its component polymethoxyflavones suppress adipogenic differentiation of human bone marrow-derived mesenchymal stem cells via the AMPK pathway
BackgroundKaempferia parviflora Wall. ex. Baker (KP) has been reported to exhibit anti-obesity effects. However, the detailed mechanism of the...
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Role of reactive oxygen species (ROS) in the regulation of adipogenic differentiation of human maxillary/mandibular bone marrow-derived mesenchymal stem cells
BackgroundMaxillary/mandibular bone marrow-derived mesenchymal stem cells (MBMSCs) exhibit a unique property of lower adipogenic potential than other...
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The Activity of Metalloproteinases in Two Placenta Mesenchymal Stem-Cell Lines from a Single Donor Differing in Adipogenic Differentiation Potential and the Nature of Replicative Aging
AbstractLong-term cultivation of two lines of human MSCs isolated from different places in the placenta was carried out. The MSC-PL-1 cell line is...
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CircDOCK7 facilitates the proliferation and adipogenic differentiation of chicken abdominal preadipocytes through the gga-miR-301b-3p/ACSL1 axis
BackgroundAbdominal fat deposition depends on both the proliferation of preadipocytes and their maturation into adipocytes, which is a...
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MME+ fibro-adipogenic progenitors are the dominant adipogenic population during fatty infiltration in human skeletal muscle
Fatty infiltration, the ectopic deposition of adipose tissue within skeletal muscle, is mediated via the adipogenic differentiation of...
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Lineage-selective super enhancers mediate core regulatory circuitry during adipogenic and osteogenic differentiation of human mesenchymal stem cells
Human mesenchymal stem cells (hMSCs) can be differentiated into osteoblasts and adipocytes. During these processes, super enhancers (SEs) play...
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Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) -derived Peptide MPAPO Stimulates Adipogenic Differentiation by Regulating the Early Stage of Adipogenesis and ERK Signaling Pathway
Regenerative medicine and tissue engineering have delivered new healing possibilities to the treatment of soft tissue defects, but the selection of...
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Cinnamaldehyde affects lipid droplets metabolism after adipogenic differentiation of C2C12 cells
BackgroundBased on our previous research conducted on cinnamaldehyde (CA) exhibiting its ability to improve the growth performance of fattening pigs...
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Oleoylethanolamide protects mesenchymal stem/stromal cells (MSCs) from oxidative stress and reduces adipogenic related genes expression in adipose-derived MSCs undergoing adipocyte differentiation
BackgroundHuman mesenchymal stem/stromal cells (hMSCs) are known for their pronounced therapeutic potential; however, they are still applied in...
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Tensin-3 is involved in osteogenic versus adipogenic fate of human bone marrow stromal cells
BackgroundThe tightly controlled balance between osteogenic and adipogenic differentiation of human bone marrow-derived stromal cells (BMSCs) is...
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Adipogenic and SWAT cells separate from a common progenitor in human brown and white adipose depots
Adipocyte function is a major determinant of metabolic disease, warranting investigations of regulating mechanisms. We show at single-cell resolution...
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The role of serum amyloid A1 in the adipogenic differentiation of human adipose-derived stem cells basing on single-cell RNA sequencing analysis
BackgroundAdipose-derived stem cells (ASCs) are obtained from a variety of sources in vivo where they present in large quantities. These cells are...
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Polarized macrophages regulate fibro/adipogenic progenitor (FAP) adipogenesis through exosomes
BackgroundMacrophage polarization has been observed in the process of muscle injuries including rotator cuff (RC) muscle atrophy and fatty...
