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NVP-AUY922 alleviates radiation-induced lung injury via inhibition of autophagy-dependent ferroptosis
Radiation-induced lung injury (RILI) is a common complication of radiotherapy for which no effective interventions are available. NVP-AUY922, a...
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Sphingolipids as a Novel Therapeutic Target in Radiation-Induced Lung Injury
Radiation-induced lung injury (RILI) is a potential complication of thoracic radiotherapy that can result in pneumonitis or pulmonary fibrosis and is...
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Role of ferroptosis in radiation-induced soft tissue injury
Ionizing radiation has been pivotal in cancer therapy since its discovery. Despite its therapeutic benefits, IR causes significant acute and chronic...
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Endothelial extracellular vesicles induce acute lung injury via follistatin-like protein 1
Cardiopulmonary bypass has been speculated to elicit systemic inflammation to initiate acute lung injury (ALI), including acute respiratory distress...
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Ultrashort wave diathermy inhibits pulmonary inflammation in mice with acute lung injury in a HSP70 independent way: a pilot study
BackgroundAcute lung injury (ALI) is a clinical syndrome characterized by pulmonary inflammation. Ultrashort wave diathermy (USWD) has been shown to...
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STAT6 inhibits ferroptosis and alleviates acute lung injury via regulating P53/SLC7A11 pathway
Compelling evidences have revealed the emerging role of ferroptosis in the pathophysiological process of acute lung injury (ALI), but its modulation...
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Superior protective effects of PGE2 priming mesenchymal stem cells against LPS-induced acute lung injury (ALI) through macrophage immunomodulation
BackgroundMesenchymal stem cells (MSCs) have demonstrated remarkable therapeutic promise for acute lung injury (ALI) and its severe form, acute...
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The role of ferroptosis in acute lung injury
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a common disease with high morbidity and mortality, and its pathogenesis is...
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ACSL4 is essential for radiation-induced intestinal injury by initiating ferroptosis
Lipid peroxidation-induced ferroptosis is a newly recognized type of programmed cell death. With the method of RNA sequencing, we found that...
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Sox9-expressing cells promote regeneration after radiation-induced lung injury via the PI3K/AKT pathway
BackgroundRadiation-induced lung injury (RILI) is considered one of the most common complications of thoracic radiation. Recent studies have focused...
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Itaconate inhibits ferroptosis of macrophage via Nrf2 pathways against sepsis-induced acute lung injury
Itaconate, a metabolite produced during inflammatory macrophage activation, has been extensively described to be involved in immunoregulation,...
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Radiation-induced liver injury and hepatocyte senescence
Radiation-induced liver injury (RILI) is a major complication of radiotherapy during treatment for liver cancer and other upper abdominal malignant...
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Haptoglobin is an early indicator of survival after radiation-induced severe injury and bone marrow transplantation in mice
BackgroundHematopoietic stem cell transplantation (HSCT) is the main treatment for acute radiation sickness, especially after fatal radiation. The...
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Applications and therapeutic mechanisms of action of mesenchymal stem cells in radiation-induced lung injury
Radiation-induced lung injury (RILI) is one of the most common complications associated with radiotherapy, characterized by early-stage radiation...
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AUF1 protects against ferroptosis to alleviate sepsis-induced acute lung injury by regulating NRF2 and ATF3
BackgroundThe AU-rich element (ARE)-binding factor 1 (AUF1) acts as a switch for septic shock, although its underlying mechanisms remain largely...
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Converting cell death into senescence by PARP1 inhibition improves recovery from acute oxidative injury
Excessive amounts of reactive oxygen species (ROS) lead to macromolecular damage and high levels of cell death with consequent pathological sequelae....
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Mitochondrial PKM2 deacetylation by procyanidin B2-induced SIRT3 upregulation alleviates lung ischemia/reperfusion injury
Apoptosis is a critical event in the pathogenesis of lung ischemia/reperfusion (I/R) injury. Sirtuin 3 (SIRT3), an important deacetylase...
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Cellular senescence of renal tubular epithelial cells in acute kidney injury
Cellular senescence represents an irreversible state of cell-cycle arrest during which cells secrete senescence-associated secretory phenotypes,...
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Silence of MLK3 alleviates lipopolysaccharide-induced lung epithelial cell injury via inhibiting p53-mediated ferroptosis
Acute lung injury (ALI) is characterized with a high rate of morbidity and mortality. The injury and apoptosis of lung epithelial cells play crucial...
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Metformin and adipose-derived stem cell combination therapy alleviates radiation-induced skin fibrosis in mice
BackgroundRadiation therapy often leads to late radiation-induced skin fibrosis (RISF), causing movement impairment and discomfort. We conducted a...
