Search
Search Results
-
Cellular mechanisms of ion and acid-base regulation in teleost gill ionocytes
The mechanism(s) of sodium, chloride and pH regulation in teleost fishes has been the subject of intense interest for researchers over the past 100...
-
Obtainment of lignocellulose degradation microbial community: the effect of acid–base combination after restrictive enrichment
Microbial communities for bioconversion of lignocellulose have received widespread attention. Many cellulose-degrading microbial communities have...
-
Impeding DNA Polymerase β Activity by Oleic Acid to Inhibit Base Excision Repair and Induce Mitochondrial Dysfunction in Hepatic Cells
Free fatty acids (FFAs) hepatic accumulation and the resulting oxidative stress contribute to several chronic liver diseases including nonalcoholic...
-
The role of octopamine and crustacean hyperglycemic hormone (CHH) in branchial acid–base regulation in the European green crab, Carcinus maenas
Crustaceans’ endocrinology is a vastly understudied area of research. The major focus of the studies on this topic to date has been on the molting...
-
Base Editing and Prime Editing
The development of new adaptations of CRISPR-based genome editing platforms, such as base editing and prime editing, made it possible to broaden the...
-
Multiplexed base editing through Cas12a variant-mediated cytosine and adenine base editors
Cas12a can process multiple sgRNAs from a single transcript of CRISPR array, conferring advantages in multiplexed base editing when incorporated into...
-
Development of multiplexed orthogonal base editor (MOBE) systems
Base editors (BEs) enable efficient, programmable installation of point mutations while avoiding the use of double-strand breaks. Simultaneous...
-
Fusion of a rice endogenous N-methylpurine DNA glycosylase to a plant adenine base transition editor ABE8e enables A-to-K base editing in rice plants
Engineering of a new type of plant base editor for simultaneous adenine transition and transversion within the editing window will greatly expand the...
-
Programmable A-to-Y base editing by fusing an adenine base editor with an N-methylpurine DNA glycosylase
Here we developed an adenine transversion base editor, AYBE, for A-to-C and A-to-T transversion editing in mammalian cells by fusing an adenine base...
-
Base editing of organellar DNA with programmable deaminases
Mitochondria and chloroplasts are organelles that include their own genomes, which encode key genes for ATP production and carbon dioxide fixation,...
-
Sodium Fluoride and Sulfur Dioxide Derivatives Induce TGF-β1-Mediated NBCe1 Downregulation Causing Acid–Base Disorder of LS8 Cells
The aim of the present work was to assess whether the combination of sodium fluoride (NaF) and sulfur dioxide derivatives (SO 2 derivatives) affects...
-
Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity
Cytosine base editors (CBEs) are larger and can suffer from higher off-target activity or lower on-target editing efficiency than current adenine...
-
Cytosine Base Editing in Bacteria
Base editing is a new genome editing technology that enables DNA base mutations without requiring double-stranded DNA backbone cleavage or a donor...
-
A Brief Review on Schiff Base, Synthesis, and Their Antimicrobial Activities
AbstractThe Schiff base chemsitry includes compounds that attracted the attention of research scope from the early years. Consequently, the Schiff...
-
Precision RNA base editing with engineered and endogenous effectors
RNA base editing refers to the rewriting of genetic information within an intact RNA molecule and serves various functions, such as evasion of the...
-
Precise mutagenesis in zebrafish using cytosine base editors
Base editing is a powerful CRISPR-based technology for introducing precise substitutions into the genome. This technology greatly advances...
-
Strand-preferred base editing of organellar and nuclear genomes using CyDENT
Transcription-activator-like effector (TALE)-based tools for base editing of nuclear and organellar DNA rely on double-stranded DNA deaminases, which...
-
Base Editors-Mediated Gene Therapy in Hematopoietic Stem Cells for Hematologic Diseases
Base editors, developed from the CRISPR/Cas system, consist of components such as deaminase and Cas variants. Since their emergence in 2016, the...
-
Generation of precision preclinical cancer models using regulated in vivo base editing
Although single-nucleotide variants (SNVs) make up the majority of cancer-associated genetic changes and have been comprehensively catalogued, little...
-
Web-Based Computational Tools for Base Editors
CRISPR-based base editors are efficient genome editing tools for use in base correction. Currently, there are various versions and types of base...