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S100a9 inhibits Atg9a transcription and participates in suppression of autophagy in cardiomyocytes induced by β1-adrenoceptor autoantibodies
BackgroundCardiomyocyte death induced by autophagy inhibition is an important cause of cardiac dysfunction. In-depth exploration of its mechanism may...
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ATG9A protects the plasma membrane from programmed and incidental permeabilization
The integral membrane protein ATG9A plays a key role in autophagy. It displays a broad intracellular distribution and is present in numerous...
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Structure, lipid scrambling activity and role in autophagosome formation of ATG9A
De novo formation of the double-membrane compartment autophagosome is seeded by small vesicles carrying membrane protein autophagy-related 9 (ATG9),...
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NMMHC IIA triggers neuronal autophagic cell death by promoting F-actin-dependent ATG9A trafficking in cerebral ischemia/reperfusion
Previous findings have shown that non-muscle myosin heavy-chain IIA (NMMHC IIA) is involved in autophagy induction triggered by starvation in D....
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The association between several autophagy-related genes and their prognostic values in hepatocellular carcinoma: a study on the foundation of TCGA, GEPIA and HPA databases
BackgroundThe purpose of this study was to investigate the relationship between the expression of autophagy-related genes and prognosis in...
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CRISPR/Cas9-mediated inactivation of miR-34a and miR-34b/c in HCT116 colorectal cancer cells: comprehensive characterization after exposure to 5-FU reveals EMT and autophagy as key processes regulated by miR-34
The miR-34a and miR-34b/c encoding genes represent direct targets of the p53 transcription factor, and presumably mediate part of the tumor...
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A neuroprotective role of Ufmylation through Atg9 in the aging brain of Drosophila
Ufmylation is a recently identified small ubiquitin-like modification, whose biological function and relevant cellular targets are poorly understood....
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Expression of LC3A, LC3B and p62/SQSTM1 autophagy proteins in hepatocellular carcinoma (HCC) tissues and the predicted microRNAs involved in the autophagy-related pathway
BackgroundAutophagy plays multifaceted roles in regulating hepatocellular carcinoma (HCC) and the mechanisms involved are under-explored. Regulatory...
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Three-dimensional growth sensitizes breast cancer cells to treatment with ferroptosis-promoting drugs
Drugs causing ferroptosis, iron-mediated cell death, represent promising tools for cancer treatment. While exploring the effect of these drugs on...
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Receptor-mediated endocytosis 8 (RME-8)/DNAJC13 is a novel positive modulator of autophagy and stabilizes cellular protein homeostasis
The cellular protein homeostasis (proteostasis) network responds effectively to insults. In a functional screen in C. elegans , we recently identified...
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The Janus-faced functions of Apolipoproteins L in membrane dynamics
The functions of human Apolipoproteins L (APOLs) are poorly understood, but involve diverse activities like lysis of bloodstream trypanosomes and...
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The citrate transporters SLC13A5 and SLC25A1 elicit different metabolic responses and phenotypes in the mouse
Cytosolic citrate is imported from the mitochondria by SLC25A1, and from the extracellular milieu by SLC13A5. In the cytosol, citrate is used by ACLY...
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Mechanism and role of mitophagy in the development of severe infection
Mitochondria produce adenosine triphosphate and potentially contribute to proinflammatory responses and cell death. Mitophagy, as a conservative...
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Acetylation modification in the regulation of macroautophagy
Macroautophagy, commonly referred to as autophagy, is an evolutionarily conserved cellular process that plays a crucial role in maintaining cellular...
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Recycling of autophagosomal components from autolysosomes by the recycler complex
Autolysosomes contain components from autophagosomes and lysosomes. The contents inside the autolysosomal lumen are degraded during autophagy, while...
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ATase inhibition rescues age-associated proteotoxicity of the secretory pathway
Malfunction of autophagy contributes to the progression of many chronic age-associated diseases. As such, improving normal proteostatic mechanisms is...
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The regulatory role of lipophagy in central nervous system diseases
Lipid droplets (LDs) are the organelles for storing neutral lipids, which are broken down when energy is insufficient. It has been suggested that...
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Introduction of long non-coding RNAs to regulate autophagy-associated therapy resistance in cancer
Autophagy is a lysosomal degradation pathway that depends on various evolutionarily conserved autophagy-related genes (ATGs). Dysregulation of...
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Replicative Senescence and Expression of Autophagy Genes in Mesenchymal Stromal Cells
AbstractCell senescence leads to a number of changes in the properties of mesenchymal stromal cells (MSCs). In particular, the number of damaged...
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The Role of Autophagy in Ferroptosis
Autophagy is a self-degrading process that helps determine the fate of cells in response to stress. Although the role of autophagy in promoting cell...