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RNAseq and quantitative proteomic analysis of Dictyostelium knock-out cells lacking the core autophagy proteins ATG9 and/or ATG16
BackgroundAutophagy is an evolutionary ancient mechanism that sequesters substrates for degradation within autolysosomes. The process is driven by...
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Complete set of the Atg8–E1–E2–E3 conjugation machinery forms an interaction web that mediates membrane sha**
Atg8, a ubiquitin-like protein, is conjugated with phosphatidylethanolamine (PE) via Atg7 (E1), Atg3 (E2) and Atg12–Atg5–Atg16 (E3) enzymatic cascade...
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Autophagy in hepatic ischemia–reperfusion injury
Hepatic ischemia–reperfusion injury (HIRI) is a major complication of liver resection or liver transplantation that can seriously affect patient’s...
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A non-canonical role of ATG8 in Golgi recovery from heat stress in plants
Above-optimal growth temperatures, usually referred to as heat stress (HS), pose a challenge to organisms’ survival as they interfere with essential...
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Activation and targeting of ATG8 protein lipidation
ATG8 family proteins are evolutionary conserved ubiquitin-like modifiers, which become attached to the headgroup of the membrane lipid...
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In vitro study of the role of FOXO transcription factors in regulating cigarette smoke extract-induced autophagy
Cigarette smoking is the chief etiological factor for chronic obstructive pulmonary disease (COPD). Oxidative stress induced by cigarette smoke (CS)...
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Autophagy protein ATG-16.2 and its WD40 domain mediate the beneficial effects of inhibiting early-acting autophagy genes in C. elegans neurons
While autophagy genes are required for lifespan of long-lived animals, their tissue-specific roles in aging remain unclear. Here, we inhibited...
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Dietary sodium acetate and sodium butyrate improve high-carbohydrate diet utilization by regulating gut microbiota, liver lipid metabolism, oxidative stress, and inflammation in largemouth bass (Micropterus salmoides)
BackgroundAdequate level of carbohydrates in aquafeeds help to conserve protein and reduce cost. However, studies have indicated that...
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SETD2 transcriptional control of ATG14L/S isoforms regulates autophagosome–lysosome fusion
Macroautophagy/autophagy is an evolutionarily conserved and tightly regulated catabolic process involved in the maintenance of cellular homeostasis...
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The evolutionary and functional divergence of the Atg8 autophagy protein superfamily
Autophagy is a highly conserved self-degradation process of eukaryotic cells which is required for the effective elimination of damaged and...
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The role of epithelial-mesenchymal transition and autophagy in pancreatic ductal adenocarcinoma invasion
Of all pancreatic cancer (PC) cases, approximately 90% are pancreatic ductal adenocarcinoma (PDAC), which progress rapidly due to its high degree of...
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Acetylation modification in the regulation of macroautophagy
Macroautophagy, commonly referred to as autophagy, is an evolutionarily conserved cellular process that plays a crucial role in maintaining cellular...
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Crosstalk between m6A modification and autophagy in cancer
Autophagy is a cellular self-degradation process that plays a crucial role in maintaining metabolic functions in cells and organisms. Dysfunctional...
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Autophagy in Cancer: A Metabolic Perspective
Autophagy is an intracellular catabolic degradative process in which damaged cellular organelles, unwanted proteins and different cytoplasmic...
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Regulation of Apoptosis and Autophagy During Anoxia in the Freshwater Crayfish, Faxonius virilis
The ability of an animal to survive prolonged periods of oxygen deprivation is a critical area of study, both in terms of its importance to better...
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Rescuing the Golgi from heat damages by ATG8: restoration rather than clean-up
High temperature stress poses significant adverse effects on crop yield and quality. Yet the molecular mechanisms underlying heat stress tolerance in...
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RUNDC1 inhibits autolysosome formation and survival of zebrafish via clas** ATG14-STX17-SNAP29 complex
Autophagy serves as a pro-survival mechanism for a cell or a whole organism to cope with nutrient stress. Our understanding of the molecular...
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Different types of cell death and their shift in sha** disease
Cell death is the irreversible stop of life. It is also the basic physiological process of all organisms which involved in the embryonic development,...
