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Calcium-permeable AMPA and kainate receptors of GABAergic neurons
This Commentary presents a brief discussion of the action of glutamate calcium permeable receptors present with neurons on the release of the...
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Allosteric competition and inhibition in AMPA receptors
Excitatory neurotransmission is principally mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-subtype ionotropic glutamate...
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Neuroprotective Effect of the Neuropeptide Cycloprolylglycine Depends on AMPA- and TrkB-Receptor Activation
AbstractPreviously, we have shown that the endogenous neuropeptide cycloprolylglycine (CPG) is the positive modulator of AMPA receptors and revealed...
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Arc weakens synapses by dispersing AMPA receptors from postsynaptic density via modulating PSD phase separation
In response to stimuli, the immediate early gene product Arc can acutely down-regulate synaptic strength by removing AMPA receptors (AMPARs) from...
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The Palmitoylation/Depalmitoylation Cycle is Involved in the Inhibition of AMPA Receptor Trafficking Induced by Aluminum In Vitro
To study the effect of the palmitoylation/depalmitoylation cycle on the inhibition of ɑ-amino-3-hydroxy-5-methyl-4-isoxazolpropionic acid (AMPA)...
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Astrocytic NMDA Receptors
AbstractAstrocytic NMDA receptors (NMDARs) are heterotetramers, whose expression and properties are largely determined by their subunit composition....
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Participation of Ca2+-Permeable AMPA Receptors in Synaptic Plasticity
AbstractAMPA receptors are the key molecules of excitatory and inhibitory synapses and are involved in synaptic plasticity. Cognitive functions of...
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Glutamate and GABA Receptors of Nerveless Animals (Placozoa): Preadaptation to Neurotransmission
Abstract —The emergence of the nervous system is one of the most important events in the evolution of life on Earth. The details of this event remain...
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The Anxiolytic Effect of the Neuropeptide Cycloprolylglycine Is Mediated by AMPA and TrkB Receptors
AbstractPreviously we have shown that the neuropeptide cycloprolylglycine is an endogenous positive modulator of AMPA receptors and assumed that the...
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The open gate of the AMPA receptor forms a Ca2+ binding site critical in regulating ion transport
Alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid receptors (AMPARs) are cation-selective ion channels that mediate most fast excitatory...
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Structural Insights into Function of Ionotropic Glutamate Receptors
Abstract —Ionotropic glutamate receptors (iGluRs) mediate fast excitatory neurotransmission. They are implicated in nervous system development and...
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A strategy can be used to analyze intracellular interaction proteomics of cell-surface receptors
Comprehensive knowledge of the intracellular protein interactions of cell-surface receptors will greatly advance our comprehension of the underlying...
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Edonerpic maleate regulates glutamate receptors through CRMP2- and Arc-mediated mechanisms in response to brain trauma
Dysfunction of ionotropic glutamate receptors (iGluRs) is a key molecular mechanism of excitotoxic neuronal injury following traumatic brain injury...
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Serotonergic Innervation of the Frog Spinal Cord and Involvement of 5-HT5A Receptors in the Modulation of Miniature Glycinergic Postsynaptic Potentials of Lumbar Motoneurons
AbstractThe role of serotonin 5-HT 5A receptors in the modulation of miniature inhibitory synaptic activity was studied using intracellular recording...
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A Bioluminescence Reporter Assay for Retinoic Acid Control of Translation of the GluR1 Subunit of the AMPA Glutamate Receptor
The present protocol describes a bioluminescence reporter assay developed to quantify the ability of synthetic agonists of retinoic acid receptors... -
Colorectal cancer promoter methylation alteration affects the expression of glutamate ionotropic receptor AMPA type subunit 4 alternative isoforms potentially relevant in colon tissue
DNA methylation alterations are early events during tumourigenesis, affecting genes involved in the crosstalk between cells and surroundings in...
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Dopamine Protects Neurons against Glutamate-Induced Excitotoxicity
Abstract —Parkinson’s disease is associated with neuronal loss in the midbrain and the resulting development of dopamine-deficient states. At the...
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Cyclin D1—Cdk4 regulates neuronal activity through phosphorylation of GABAA receptors
Nuclear Cyclin D1 (Ccnd1) is a main regulator of cell cycle progression and cell proliferation. Interestingly, Ccnd1 moves to the cytoplasm at the...
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Two types of GLR channels cooperate differently in light and dark growth of Arabidopsis seedlings
BackgroundGLutamate Receptor-like (GLR) channels are multimeric, ionotropic, ligand-gated plant transmembrane receptors. They are homologous to...
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Visualization, Properties, and Functions of GABAergic Hippocampal Neurons Containing Calcium-Permeable Kainate and AMPA Receptors
AbstractCalcium-permeable kainate (CP-KARs) and AMPA (CP-AMPARs) receptors of the brain neurons are active participants of synaptic plasticity and...