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Helicobacter pylori 23S rRNA gene A2142G, A2143G, T2182C, and C2195T mutations associated with clarithromycin resistance detected in Sudanese patients
BackgroundClarithromycin resistant Helicobacter pylori ( H. pylori ) strains represent a worldwide health problem. These stains are usually carrying...
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Quantitative multiplex real-time polymerase chain reaction assay for the detection of Helicobacter pylori and clarithromycin resistance
BackgroundIdentifying clarithromycin resistance is essential for eradicating Helicobacter pylori (HP). Therefore, we evaluated the performance of...
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Correlation between clarithromycin resistance, virulence factors and clinical characteristics of the disease in Helicobacter pylori infected patients in Shahrekord, Southwest Iran
The purpose of this study was to determine the mutations associated with clarithromycin resistance in Helicobacter pylori strains isolated from...
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Development of diagnostic tests for pathogen identification and detection of antimicrobial resistance on WHO global priority pathogens using modular real-time nucleic acid amplification test
BackgroundConcerns regarding antimicrobial resistance (AMR) have resulted in the World Health Organization (WHO) designating so-called global...
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Investigation of Clarithromycin Resistance-Associated Mutations and Virulence Genotypes of Helicobacter pylori Isolated from Iranian Population: A Cross-Sectional Study
Antibiotic resistance has brought into question the efficiency of clarithromycin which is a vital component of eradication therapy for Helicobacter...
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Genomic Tools in Clinical Epidemiology
The advent of high-throughput technologies, including next-generation sequencing (NGSs), is currently revolutionizing our understanding of several... -
Characterization of clarithromycin heteroresistance among Helicobacter pylori strains isolated from the antrum and corpus of the stomach
Mixed infections and heteroresistance of Helicobacter pylori contribute to decreased efficacy of treatments. This study aimed to investigate...
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Helicobacter pylori in the post-antibiotics era: from virulence factors to new drug targets and therapeutic agents
Helicobacter pylori is considered one of the most prevalent human pathogenic microbes globally. It is the main cause of a number of gastrointestinal...
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Emerging Helicobacter pylori levofloxacin resistance and novel genetic mutation in Nepal
BackgroundThe prevalence of Helicobacter pylori antibiotic susceptibility in the Nepalese strains is untracked. We determined the antibiotic...
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Anti-Helicobacter pylori activities of selected N-substituted cinnamamide derivatives evaluated on reference and clinical bacterial strains
In this study, thirty-five N -substituted derivatives of cinnamic acid amide (cinnamamide) were evaluated for anti- Helicobacter pylori activity using...
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Three unsuccessful treatments of Helicobacter pylori infection by a highly virulent strain with quadruple antibiotic resistance
We report a case of an adult patient undergoing three unsuccessful Helicobacter pylori treatments, including proton pump inhibitor (PPI), bismuth...
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Molecular mechanisms of formation of drug resistance in Neisseria gonorrhoeae: History and prospects
Neisseria gonorrhoeae (gonococcus) is a strict human pathogen that causes gonorrhea—an infectious disease the origin of which dates back more than...
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Phenotypic and genotypic analysis of clarithromycin-resistant Helicobacter pylori from Bogotá D.C., Colombia
Resistance of Helicobacter pylori to clarithromycin is the most common cause of treatment failure in patients with H. pylori infections. This study...
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Detection of primary clarithromycin resistance of Helicobacter pylori and association between cagA + status and clinical outcome
Helicobacter pylori was examined in 110 patients (82 (74.5) with gastritis, 18 (16.4) with duodenitis, six (5.5) with duodenal ulcer and...
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PNA-FISH as a new diagnostic method for the determination of clarithromycin resistance of Helicobacter pylori
BackgroundTriple therapy is the gold standard treatment for Helicobacter pylori eradication from the human stomach, but increased resistance to...
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Prevalence of A2143G mutation of H. pylori-23S rRNA in Chinese subjects with and without clarithromycin use history
BackgroundA2143G mutation of 23S rRNA gene of H. pylori results in clarithromycin (CLR) resistance. To investigate the prevalence of the CLR...
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Development of a Highly Sensitive Method for Detection of Clarithromycin-Resistant Helicobacter pylori from Human Feces
Gastric infection of clarithromycin (CAM)-resistant Helicobacter pylori is one of the major causes of failure to eradicate this organism. A...
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High level of resistance to metronidazole and clarithromycin inHelicobacter pylori isolated from pediatric patients in Poland (1997–2001)
Resistance to metronidazole (Met), clarithromycin (Cla) and amoxycillin (Amo) was examined using H. pylori isolates from child patients before and...