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Isoform-Selective Nox Inhibitors: Advances and Future Perspectives
The NADPH oxidase family of proteins are professional reactive oxygen species (ROS)-generating enzymes that generate superoxide (O2−) by transferring...
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Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy
Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has a crucial role in...
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Synthesis and characterization of novel acyl hydrazones derived from vanillin as potential aldose reductase inhibitors
In the polyol pathway, aldose reductase (AR) catalyzes the formation of sorbitol from glucose. In order to detoxify some dangerous aldehydes, AR is...
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Meta-analysis of the effects of proton pump inhibitors on the human gut microbiota
Mounting evidence has linked changes in human gut microbiota to proton pump inhibitor (PPI) use. Accordingly, multiple studies have analyzed the gut...
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Experimental Evaluation of 3-meta-Pyridine-1,2,4-Oxadiazole Derivative of Deoxycholic Acid as a Prototype of 5-α-Reductase Inhibitors in In Silico and In Vivo Models
Abstract—It is considered that 5-α-reductase (5-AR) inhibitors are the most effective drugs for suppressing proliferative processes in prostate...
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Ensemble learning application to discover new trypanothione synthetase inhibitors
Trypanosomatid-caused diseases are among the neglected infectious diseases with the highest disease burden, affecting about 27 million people...
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Less Frequently Used Growth Regulators in Plant Tissue Culture
Plant growth regulators are routinely added to in vitro culture media to foster the growth and differentiation of the cells, tissues, and organs....
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Design, synthesis, and molecular modeling of heterodimer and inhibitors of α-amylase as hypoglycemic agents
A series of rosiglitazone-based heterodimers were designed and synthesized, and their α-amylase and antioxidant activity was evaluated. The binding...
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Bacterial Cell Wall Biosynthesis and Inhibitors
The bacterial cell wall is composed of peptidoglycan layer which has alternating units of N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM)...
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Plant Recombinant Gene Technology for Pest Control in the Twenty-First Century: From Simple Transgenesis to CRISPR/Cas
The current progress in genetic technologies (methodologies) allows to create crops with the modified genome to counter different pest species....
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Design and development of novel inhibitors of aldo-ketoreductase 1C1 as potential lead molecules in treatment of breast cancer
Aldo–keto reductase 1C1 (AKR1C1) is a hydroxysteroid dehydrogenase, known to inactivate the biologically active progesterone into its corresponding...
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Detecting and Quantifying pADPr In Vivo
Poly(ADP-ribose) polymerases (PARP) participate in diverse biological processes contributing to cellular homeostasis or exacerbating injury. PARP...
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Physiological characterization and transcriptome analysis of Pichia pastoris reveals its response to lignocellulose-derived inhibitors
The negative effects of lignocellulose-derived inhibitors such as acetic acid and furaldehydes on microbial metabolism constitute a significant...
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Structure and dynamics of pteridine reductase 1: the key phenomena relevant to enzyme function and drug design
Pteridine reductase 1 (PTR1) is a folate and pterin pathway enzyme unique for pathogenic trypanosomatids. As a validated drug target, PTR1 has been...
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Develo** therapeutic approaches for chronic myeloid leukemia: a review
Modern clinical therapy of chronic myeloid leukemia (CML) with TKIs is highly efficacious in most CML patients, while it is not remedial and...
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The Cholesterol-5,6-Epoxide Hydrolase: A Metabolic Checkpoint in Several Diseases
Cholesterol-5,6-epoxides (5,6-ECs) are oxysterols (OS) that have been linked to several pathologies including cancers and neurodegenerative diseases....
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Drug-Resistant Epithelial Ovarian Cancer: Current and Future Perspectives
Epithelial ovarian cancer (EOC) is a complex disease with diverse histological subtypes, which, based on the aggressiveness and course of disease...
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Homology Modeling of 5-alpha-Reductase 2 Using Available Experimental Data
5-Alpha-reductase 2 is an interesting pharmaceutical target for the treatment of several diseases, including prostate cancer, benign prostatic...
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Synthesis, Cytotoxicity and In Vitro α-Glucosidase Inhibition of New N-Substituted Glitazone and Rhodanine Derivatives
AbstractDiabetes Mellitus remains a serious threat to human life and the global economy and hence its cure remains a challenge. In an attempt to find...
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Diphtheria toxin, diphtheria-related fusion protein toxins, and the molecular mechanism of their action against eukaryotic cells
Diphtheria toxin remains one of the most successfully studied of the bacterial protein toxins. A detailed understanding of the structure function...