Search
Search Results
-
Expression assay of calcium signaling related lncRNAs in autism
BackgroundCalcium signaling has essential roles in the neurodevelopmental processes and pathophysiology of related disorders for instance autism...
-
A natural mouse model reveals genetic determinants of systemic capillary leak syndrome (Clarkson disease)
The systemic capillary leak syndrome (SCLS, Clarkson disease) is a disorder of unknown etiology characterized by recurrent episodes of vascular...
-
Calcium signaling in neurodevelopment and pathophysiology of autism spectrum disorders
BackgroundAutism spectrum disorder (ASD) covers a group of neurodevelopmental disorders with complex genetic background. Several genetic mutations,...
-
LncRNA in tumorigenesis of non-small-cell lung cancer: From bench to bedside
Lung cancer has been one of the leading causes of cancer-related death worldwide, and non-small-cell lung cancer (NSCLC) accounts for the majority of...
-
LncRNA linc00312 suppresses radiotherapy resistance by targeting DNA-PKcs and impairing DNA damage repair in nasopharyngeal carcinoma
Radioresistance is the main obstacle in the clinical management of nasopharyngeal carcinoma (NPC). linc00312 is deregulated in a number of human...
-
A genetic locus complements resistance to Bordetella pertussis-induced histamine sensitization
Histamine plays pivotal role in normal physiology and dysregulated production of histamine or signaling through histamine receptors (HRH) can promote...
-
Multiple functions of autophagy in vascular calcification
BackgroundVascular calcification is a closely linked to cardiovascular diseases, such as atherosclerosis, chronic kidney disease, diabetes,...
-
VHL Ser65 mutations enhance HIF2α signaling and promote epithelial-mesenchymal transition of renal cancer cells
BackgroundVon Hippel-Lindau (VHL) disease is an autosomal dominant genetic neoplastic disorder caused by germline mutation or deletion of the VHL ...
-
Over-expression of lncRNA TMEM161B-AS1 promotes the malignant biological behavior of glioma cells and the resistance to temozolomide via up-regulating the expression of multiple ferroptosis-related genes by sponging hsa-miR-27a-3p
A growing body of evidence suggests that long-chain non-coding RNA (lncRNA) plays an important role in the malignant biological behavior and drug...
-
Genetic alterations in the 3q26.31-32 locus confer an aggressive prostate cancer phenotype
Large-scale genetic aberrations that underpin prostate cancer development and progression, such as copy-number alterations (CNAs), have been...
-
miRNA-21 promotes cell proliferation and invasion via VHL/PI3K/AKT in papillary thyroid carcinoma
Papillary thyroid carcinoma (PTC) is the main kind of thyroid carcinoma, most of which are diagnosed in women. MiR-21 has been reported to be...
-
Integrative Analysis of Multi-Genomic Data for Kidney Renal Cell Carcinoma
Accounting for nine out of ten kidney cancers, kidney renal cell carcinoma (KIRC) is by far the most common type of kidney cancer. In view of limited...
-
Genetic etiologies of the electrical status epilepticus during slow wave sleep: systematic review
BackgroundElectrical status epilepticus during slow-wave sleep (ESESS) which is also known as continuous spike-wave of slow sleep (CSWSS) is type of...
-
Investigation of major genetic alterations in neuroblastoma
Neuroblastoma (NB) is the most common extracranial solid tumor in childhood. This malignancy shows a wide spectrum of clinical outcome and its...
-
Long non-coding RNA expression in bladder cancer
The advent of novel high-throughput sequencing methods has facilitated identification of non-coding RNAs with fundamental roles in cellular...
-
Genome-wide imaging association study implicates functional activity and glial homeostasis of the caudate in smoking addiction
BackgroundNearly 6 million deaths and over a half trillion dollars in healthcare costs worldwide are attributed to tobacco smoking each year....
-
Application of NGS in the Diagnosis of Cardiovascular Genetic Diseases
Cardiovascular diseases (CVDs) are the leading global cause of death and encompass a broad range of disorders, including diseases of the vasculature,...
-
Knockdown of POLA2 increases gemcitabine resistance in lung cancer cells
BackgroundGemcitabine is used as a standard drug treatment for non-small cell lung cancer (NSCLC), but treatment responses vary among patients. Our...
-
Array comparative genomic hybridization and genomic sequencing in the diagnostics of the causes of congenital anomalies
The aim of this review is to provide the current state of knowledge about the usefulness of modern genetic technologies in uncovering the causality...
-
CollapsABEL: an R library for detecting compound heterozygote alleles in genome-wide association studies
BackgroundCompound Heterozygosity (CH) in classical genetics is the presence of two different recessive mutations at a particular gene locus. A...
