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Translational regulation of δ-tubulin through its 5’-untranslated region
Backgroundδ-tubulin - a member of tubulin superfamily, is found in a subset of eukaryotes including human where it has a role in centriole...
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Translational regulation and protein-coding capacity of the 5′ untranslated region of human TREM2
TREM2 is a transmembrane receptor expressed in microglia and macrophages. Elevated TREM2 levels in these cells are associated with age-related...
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Effects of sequence motifs in the yeast 3′ untranslated region determined from massively parallel assays of random sequences
BackgroundThe 3′ untranslated region (UTR) plays critical roles in determining the level of gene expression through effects on activities such as...
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The 5’ untranslated region variant rs3811050 C/T of the interleukin-38 encoding gene is associated with susceptibility to rheumatoid arthritis in Iraqi women
BackgroundInterleukin (IL)-38, the latest member of the IL-1 cytokine family, is proposed to have a pathogenic role in rheumatoid arthritis (RA). It...
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Folliculin-interacting protein FNIP2 impacts on overweight and obesity through a polymorphism in a conserved 3′ untranslated region
BackgroundOverweight and obesity are defined by an anomalous or excessive fat accumulation that may compromise health. To find single-nucleotide...
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Genome-wide mutation frequency variation among SARS-CoV-2 variants and its effects on the untranslated regions
AbstractThere is a pressing need for ongoing vigilance and genetic scrutiny of the SARS-CoV-2 virus that devastated humanity globally since its...
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Eukaryotic initiation factor 5A hypusine as a negative regulator of adenosine 2B receptor (A2bAR) through interaction with stem loop sequences within the A2bAR 3′-untranslated region
PurposeThe aim of this study was to investigate whether eIF5A hypusine (eIF5A Hyp ) reduces adenosine 2b receptor (A2bAR) gene expression through...
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Differences in 5'untranslated regions highlight the importance of translational regulation of dosage sensitive genes
BackgroundUntranslated regions (UTRs) are important mediators of post-transcriptional regulation. The length of UTRs and the composition of...
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SARS-CoV-2 RNA Genome
Coding regionsCoding regions of the genome are translated into several non-structural proteins, as well as into the widely studied spike protein,...
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Characterization of a putative ribosome binding site at the 5′ untranslated region of bovine heat shock protein 90
Untranslated regions (UTRs) of the transcripts play significant roles in translation regulation and continue to raise many intriguing questions in...
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Reduced translation efficiency due to novel splicing variants in 5′ untranslated region and identification of novel cis-regulatory elements in canine and human BRCA2
BackgroundBreast cancer 2, early onset ( BRCA2 ) is a tumor suppressor gene. The protein encoded by this gene plays an important role in homologous...
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Effects of chronic ammonia nitrogen stress on hydrolases and interleukin 17–3 (IL-17–3) in clam Cyclina sinensis
Ammonia nitrogen is an unavoidable factor in aquaculture, and it may have a severe effect on clam breeding. To explore the toxic effect of ammonia...
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APA-Scan: detection and visualization of 3′-UTR alternative polyadenylation with RNA-seq and 3′-end-seq data
BackgroundThe eukaryotic genome is capable of producing multiple isoforms from a gene by alternative polyadenylation (APA) during pre-mRNA...
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3′ UTR is critical for viral RNA accumulation of jasmine virus H
Jasmine virus H (JaVH) is a newly reported viral pathogen of jasmine in China and USA. To study the viral gene function and pathogenic mechanism, a...
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Molecular characterization of the nonstructural 5A (NS5A) region of hepatitis C virus in Thai blood donors
Direct acting antivirals (DAAs) have been developed for hepatitis C virus (HCV) therapy, and they are usually effective, however resistance to DAA...
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Evaluating Single-Nucleotide Variants in MicroRNA Targeting Sites and Mature MicroRNA In Vitro Cell Culture by Luciferase Reporter Gene Assays
MicroRNAs (miRs) are small non-coding RNAs of 21–24 nucleotides in length that modulate gene expression by targeting the untranslated region (UTR) of...
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The Functions of N-methyladenosine (m6A) Modification on HIV-1 mRNA
In recent years, there has been a growing interest in the study of RNA modifications, with some researchers focusing specifically on the connection...
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Mutations in the non-structural protein coding region regulate gene expression from replicon RNAs derived from Venezuelan equine encephalitis virus
Self-replicating RNA (repRNA) derived from Venezuelan equine encephalitis (VEE) virus is a promising platform for gene therapy and confers prolonged...
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Mitigating cadmium accumulation in rice without compromising growth via modifying the regulatory region of OsNRAMP5
Cadmium (Cd) intake poses a significant health risk to humans, and the contamination of rice grains with Cd is a major concern in regions where rice...
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PRPF19 mRNA Encodes a Small Open Reading Frame That Is Important for Viability of Human Cells
AbstractHigh-throughput ribosome profiling demonstrates the translation of thousands of small open reading frames located in the 5′ untranslated...
