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P19-derived neuronal cells express H1, H2, and H3 histamine receptors: a biopharmaceutical approach to evaluate antihistamine agents
Histamine is a biogenic amine implicated in various biological and pathological processes. Convenient cellular models are needed to screen and...
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Innovative cascade reaction for 2H-indazole derivative synthesis
In the realm of synthetic organic chemistry, by using a one-pot sequential combination of MCR, it is possible to manufacture chemical commodities...
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A Versatile Approach for the Synthesis, Characterization, and Bioassay of Novel 3-(1-Acetyl-5-substituted phenyl-4, 5-dihydro-1H-pyrazol-3-yl)-4-hydroxy-1-methyl/phenylquinolin-2(1H)-one Derivatives
AbstractA series of novel 3-(1-acetyl-5-substitutedphenyl-1 H -pyrazol-3-yl)-4-hydroxy-1-methylquinolin-2(1 H )-ones ( Va–Vf ) and...
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Ferroptotic alveolar epithelial type II cells drive TH2 and TH17 mixed asthma triggered by birch pollen allergen Bet v 1
Asthma is a common allergic disease characterized by airway hypersensitivity and airway remodeling. Ferroptosis is a regulated death marked by iron...
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Sabal mauritiiformis (H. Kars.) Griseb. & H. Wendl. Sabal mexicana Mart. Sabal pumos (Kunth) Burret Sabal uresana Trel. Sabal yapa C. Wright ex Becc. Arecaceae
Sabal mauritiiformis (H. Kars.) Griseb. & H. Wendl.: Sabal allenii L.H. Baileynii L.H. Bailey; Sabal glaucescens Lodd. ex H.E. Moore; Sabal...
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Multicomponent synthesis of 3-(1H-indol-3-yl)-2-phenyl-1H-benzo[f]indole-4,9-dione derivatives
Herein, we report a one-pot greener methodology for the synthesis of 3-(1 H -indol-3-yl)-2-phenyl-1 H -benzo[ f ]indole-4,9-dione derivatives by the...
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Sanghuangporus lonicerinus (Bondartsev) Sheng H. Wu, L.W. Zhou & Y.C. Dai - HYMENOCHAETACEAE
Sanghuangporus lonicerinus (Bondartsev) Sheng H. Wu, L.W. Zhou & Y.C. Dai - HYMENOCHAETACEAE
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Iron-catalyzed intermolecular cross-dehydrogenative C(sp3)–H/C(sp)–H coupling of pyrimidine bearing 4-thiazolidinones with terminal alkynes
A novel, simple and efficient protocol for the Fe-catalyzed, intermolecular cross-dehydrogenative coupling of pyrimidine bearing 4-thiazolidinones...
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Development of novel 9H-carbazole-4H-chromene hybrids as dual cholinesterase inhibitors for the treatment of Alzheimer’s disease
Alzheimer’s disease (AD) is a neurodegenerative disease affecting mental ability and neurocognitive functions. Cholinesterase enzymes affect...
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Assaying the Effect of Peptide Treatment on H+-Pum** Activity in Plasma Membranes from Arabidopsis Seedlings
Extracellular acidification or alkalization is a common response to many plant-signaling peptides and microbial elicitors. This may be a result of...
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Monitoring NAD(H) and NADP(H) dynamics during organismal development with genetically encoded fluorescent biosensors
Cell metabolism plays vital roles in organismal development, but it has been much less studied than transcriptional and epigenetic control of...
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Ruthenium-Promoted On-DNA C-H Activation Reaction
DNA-compatible C-H activations expand the chemical space of DNA-encoded library. Here we describe the ruthenium-promoted C-H activation between...
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Measurement of NAD(P)H and NADPH-Generating Enzymes
Pyridine nucleotides (NAD(H) and NADP(H)) are key redox carriers in cells and may also have other functions related to stress. These two molecules...
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H-ACO with Consecutive Bases Pairing Constraint for Designing DNA Sequences
DNA computing is a novel computing method that does not rely on traditional computers. The design of DNA sequences is a crucial step in DNA...
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Annotating genetic variants to target genes using H-MAGMA
An outstanding goal in modern genomics is to systematically predict the functional outcome of noncoding variation associated with complex traits. To...
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Interactions of arene ruthenium(II) complexes [η6-(C6H6)Ru(pprip)Cl]+ and [η6-(C6H6)Ru(H2iiP)Cl]+ with RNA triplex poly(U)•poly(A)*poly(U)
Two arene ruthenium(II) complexes [ η 6 -(C 6 H 6 )Ru(pprip)Cl]PF 6 (Ru 1 ; pprip = 2-(3-phenyl-1H-pyrazol-4-yl)-imidazolo[4,5- f ][1,10]phenanthroline) and [ η 6 -(C...
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Kir4.1 channels contribute to astrocyte CO2/H+-sensitivity and the drive to breathe
Astrocytes in the retrotrapezoid nucleus (RTN) stimulate breathing in response to CO 2 /H + , however, it is not clear how these cells detect changes in...
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Structural basis for enzymatic terminal C–H bond functionalization of alkanes
Alkane monooxygenase (AlkB) is a widely occurring integral membrane metalloenzyme that catalyzes the initial step in the functionalization of...
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In Vitro Reconstitution of Pseudouridylation Catalyzed by Human Box H/ACA Ribonucleoprotein Particles
Pseudouridine (Ψ) is the most common chemical modification in RNA. In eukaryotes and archaea, pseudouridine synthases, mainly guided by box H/ACA...
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Plasma membrane-localized H+-ATPase OsAHA3 functions in saline–alkaline stress tolerance in rice
Key messageA novel function of plasma membrane-localized H + -ATPase, OsAHA3, was identified in rice, which is involved in saline–alkaline tolerance...
