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Phenotypes and Functions of Human Dendritic Cell Subsets in the Tumor Microenvironment
Dendritic cells (DCs) play a key role in the antitumor immunity, as they are at the interface of innate and adaptive immunity. This important task...
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Signification and Application of Mutator and Antimutator Phenotype-Induced Genetic Variations in Evolutionary Adaptation and Cancer Therapeutics
Mutations present a dichotomy in their implications for cellular processes. They primarily arise from DNA replication errors or damage repair...
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Participation of Mesenchymal Stem Cells in the Tumor Process
Although most mesenchymal stem cell (MSCs) studies have focused on evaluating the safety and efficacy of their use as therapeutic agents in...
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PARP1 and XRCC1 exhibit a reciprocal relationship in genotoxic stress response
PARP1 (aka ARTD1) acts as a prime sensor of cellular genotoxic stress response. PARP1 detects DNA strand breaks and subsequently catalyzes the...
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Dynamic RBM47 ISGylation confers broad immunoprotection against lung injury and tumorigenesis via TSC22D3 downregulation
ISGylation is a well-established antiviral mechanism, but its specific function in immune and tissue homeostasis regulation remains elusive. Here, we...
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Trophic dynamics and properties of the marine ecosystem of Campeche Bank, Mexico
Campeche Bank located in the Yucatan Peninsula, Mexico is characterized by particular oceanographic and physiographic conditions that promote great...
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Improved wood species identification based on multi-view imagery of the three anatomical planes
BackgroundThe identification of tropical African wood species based on microscopic imagery is a challenging problem due to the heterogeneous nature...
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Single-cell analysis of endometriosis reveals a coordinated transcriptional programme driving immunotolerance and angiogenesis across eutopic and ectopic tissues
Endometriosis is characterized by the growth of endometrial-like tissue outside the uterus. It affects many women during their reproductive age,...
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A predictive timeline of wildlife population collapse
Contemporary rates of biodiversity decline emphasize the need for reliable ecological forecasting, but current methods vary in their ability to...
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Studies of the Ecology of the Benguela Current Upwelling System: The TRAFFIC Approach
Under the umbrella of SPACES (Science Partnerships for the Adaptation to Complex Earth System Processes in Southern Africa), several marine projects...
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ATR mediates cisplatin resistance in 3D-cultured breast cancer cells via translesion DNA synthesis modulation
Tissue architecture and cell–extracellular matrix (cell–ECM) interaction determine the organ specificity; however, the influences of these factors on...
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Multiregion WES of metastatic pancreatic neuroendocrine tumors revealed heterogeneity in genomic alterations, immune microenvironment and evolutionary patterns
Pancreatic neuroendocrine tumors (PanNETs), though uncommon, have a high likelihood of spreading to other body parts. Previously, the genetic...
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A machine learning approach for accurate and real-time DNA sequence identification
BackgroundThe all-electronic Single Molecule Break Junction (SMBJ) method is an emerging alternative to traditional polymerase chain reaction (PCR)...
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Continuous Monitoring of Tree Responses to Climate Change for Smart Forestry: A Cybernetic Web of Trees
Trees are long-lived organisms that contribute to forest development over centuries and beyond. However, trees are vulnerable to increasing natural...
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Differences in regulation mechanisms of glutamine synthetases from methanogenic archaea unveiled by structural investigations
Glutamine synthetases (GS) catalyze the ATP-dependent ammonium assimilation, the initial step of nitrogen acquisition that must be under tight...
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Productive performance of lactating Brown Swiss cows grazing on an agrosilvopastoral system in a dry tropical region in central Mexico: contribution of grass, herbaceous and woody species
Cattle production in agrosilvopastoral systems (ASPS) in the dry tropical regions of Mexico relies on forages under extensive management with limited...
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A 217-year precipitation reconstruction in the Habahe area, **njiang, Northeast China
Evaluating long-term changes in precipitation resources is important for accurate hydrological evaluation and forecasting, water security and...
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Microbial Secondary Metabolites: Targeting Tumors and Associated Challenges
Secondary metabolites derived from microbes have been utilized for a number of applications in the medical sector for a considerable time. Microbial...
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An ecopath model for fisheries management in the Mogador marine protected area (Moroccan, Atlantic)
The high exploitation of marine fisheries resources for their economic value along with climate change in recent decades is threatening the...
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Antimicrobial Activity of Lipid Extracts of Echinoderms in the Nhatrang Bay (South China Sea)
AbstractThe obtained results on the study of the antimicrobial activity of lipid extracts of tissues of starfishes Linckia laevigata and Culcita...
