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Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR γ agonists on rat primary hepatocytes and human HepG2 cells
Agonists of peroxisome proliferator-activated receptor γ (PPARγ) are a new class of oral drugs designed to treat insulin-resistant diabetes (i.e.,...
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Many accurate small-discriminatory feature subsets exist in microarray transcript data: biomarker discovery
BackgroundMolecular profiling generates abundance measurements for thousands of gene transcripts in biological samples such as normal and tumor...
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Regulation of T-cell death-associated gene 51 (TDAG51) expression in human T-cells
T-cell death-associated gene 51 (TDAG51) has been described to regulate T-cell receptor/CD3-dependent induction of CD95/Fas and subsequent...
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Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol
BackgroundFlavopiridol, a flavonoid currently in cancer clinical trials, inhibits cyclin-dependent kinases (CDKs) by competitively blocking their...