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OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases
Patients with primary mitochondrial oxidative phosphorylation (OxPhos) defects present with fatigue and multi-system disorders, are often lean, and...
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High-Throughput Rapid Yeast Chronological Lifespan Assay
The budding yeast is a valuable model system for discovering molecular mechanisms underlying cellular aging. This is due to the ease of performing...
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Administration of krill oil extends lifespan of fish Nothobranchius guentheri via enhancement of antioxidant system and suppression of NF-κB pathway
Krill oil (KO) extracted from Antarctic krill ( Euphausia superba ) mainly comprises phospholipids and triglycerides. KO has been shown to prolong the...
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Occasional and constant exposure to dietary ethanol shortens the lifespan of worker honey bees
Honey bees ( Apis mellifera ) are one of the most crucial pollinators, providing vital ecosystem services. Their development and functioning depend on...
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Pollination-associated shortening of the functional flower lifespan in an alpine species of Alstroemeria and the water content of flowers
Pollination-induced flower senescence is expected in species of dry habitats with large long-lived water-demanding flowers as means for reducing...
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Honeysuckle extract (Lonicera pallasii L.) exerts antioxidant properties and extends the lifespan and healthspan of Drosophila melanogaster
Honeysuckle Lonicera pallasii ( Lonicera caerulea L.) is an excellent source of anthocyanins which have a number of health-promoting properties mainly...
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Lifespan prolonging mechanisms and insulin upregulation without fat accumulation in long-lived reproductives of a higher termite
Kings and queens of eusocial termites can live for decades, while queens sustain a nearly maximal fertility. To investigate the molecular mechanisms...
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Effects of mating age and mate age on lifespan and reproduction in a horned beetle
AbstractMating young can cause early death due to resulting energetic depletion, physical damage, or sexually transmitted disease, whereas waiting...
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Oolonghomobisflavans from Camellia sinensis increase Caenorhabditis elegans lifespan and healthspan
Tea polyphenols are widely considered as excellent antioxidant agents which can contribute to human health and longevity. However, the identification...
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Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice
Elimination of senescent cells (senolysis) was recently reported to improve normal and pathological changes associated with aging in mice
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Cardiovascular correlates of epigenetic aging across the adult lifespan: a population-based study
Individuals with a similar chronological age can exhibit marked differences in cardiovascular risk profiles, but it is unknown whether this variation...
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Map** sex differences in the effects of protein and carbohydrates on lifespan and reproduction in Drosophila melanogaster: is measuring nutrient intake essential?
Understanding how diet affects reproduction and survival is a central aim in evolutionary biology. Although this relationship is likely to differ...
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Caenorhabditis elegans DAF-16 regulates lifespan and immune responses to Cryptococcus neoformans and Cryptococcus gattii infections
BackgroundCryptococcosis is a life-threatening infection is primarily caused by two sibling species Cryptococcus neoformans and Cryptococcus gattii. ...
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Leucine supplementation mimics the effects of caloric restriction on yeast chronological lifespan
BackgroundsLeucine prototrophic yeast exhibits extended longevity and related phenotypes similar to yeast grown under calorie restriction (CR)...
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High temperatures during microsporogenesis fatally shorten pollen lifespan
Many crop species are cultivated to produce seeds and/or fruits and therefore need reproductive success to occur. Previous studies proved that high...
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DNA ligase IV mutations confer shorter lifespan and increased sensitivity to nutrient stress in Drosophila melanogaster
The nonhomologous end-joining pathway is a primary DNA double-strand break repair pathway in eukaryotes. DNA ligase IV (Lig4) catalyzes the final...
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Human adipose-derived stromal cells transplantation prolongs reproductive lifespan on mouse models of mild and severe premature ovarian insufficiency
BackgroundAlthough recent studies have investigated the ability of Mesenchymal Stromal Cells (MSCs) to alleviate short-term ovarian damage in animal...
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Selecting on age of female reproduction affects lifespan in both sexes and age-dependent reproductive effort in female (but not male) Ceratitis cosyra
AbstractThe trade-off between lifespan and reproduction is central to our understanding of life-history evolution. Laboratory selection experiments...
