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Upstream open reading frames regulate translation of cancer-associated transcripts and encode HLA-presented immunogenic tumor antigens
BackgroundUpstream open reading frames (uORFs) represent translational control elements within eukaryotic transcript leader sequences. Recent data...
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Breaking Barriers: Nucleic Acid Aptamers in Gastrointestinal (GI) Cancers Therapy
Conventional cancer therapies can have significant adverse effects as they are not targeted to cancer cells and may damage healthy cells....
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Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response
Personalized immunotherapy targeting tumor-specific antigens (TSAs) could generate efficient and safe antitumor immune response without damaging...
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TRIP13 regulates DNA repair pathway choice through REV7 conformational change
DNA double-strand breaks (DSBs) are repaired through homology-directed repair (HDR) or non-homologous end joining (NHEJ). BRCA1/2 -deficient cancer...
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Diet of fishes and food web structure of Lake Langcuo assessed from Tibetan Plateau, southwest China
The diet of Gymnocypris species and the food web structure in Lake Langcuo (4300 m above sea level) of the southwest Tibetan Plateau of China were...
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Influence of heterozygosity and competition on morphological tree characteristics of Quercus rubra L.: a new single-tree based approach
In Europe, the non-native Northern red oak ( Quercus rubra L.) is widely recommended for future cultivation. However, outside its natural range,...
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Transcriptome analysis reveals the key pathways and candidate genes involved in salt stress responses in Cymbidium ensifolium leaves
BackgroundCymbidium ensifolium L. is known for its ornamental value and is frequently used in cosmetics. Information about the salt stress response...
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X-Ray Crystallography for Macromolecular Complexes
X-ray crystallography has for most of the last century been the standard technique to determine the high-resolution structure of biological...
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Analysis of Protein Synthesis in Cucumber Leaves after Inoculation with Corynespora cassiicola: A Proteomic Approach
Cucumber target leaf spot (TLS) disease caused by Corynespora cassiicola has become one of the most important fungal foliar diseases of cultivated...
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C-to-G editing generates double-strand breaks causing deletion, transversion and translocation
Base editors (BEs) introduce base substitutions without double-strand DNA cleavage. Besides precise substitutions, BEs generate low-frequency...
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Case Study #5: CXCR4-Targeted Radiotherapeutics
Radiopharmaceutical therapy (RPT) has become a mainstay of modern oncology but remains limited to solid tumors, including orphan diseases such as...
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Single-cell profiling of immune cells after neoadjuvant pembrolizumab and chemotherapy in IIIA non-small cell lung cancer (NSCLC)
The combination of immune checkpoint inhibitors (ICIs) with chemotherapy (chemoimmunotherapy) in the neoadjuvant setting have achieved favorable...
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DNA replication and replication stress response in the context of nuclear architecture
The DNA replication process needs to be coordinated with other DNA metabolism transactions and must eventually extend to the full genome, regardless...
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Advances in lymphatic metastasis of non-small cell lung cancer
Lung cancer is a deeply malignant tumor with high incidence and mortality. Despite the rapid development of diagnosis and treatment technology,...
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Detection and Analysis of Microtubule Nucleator γ-Tubulin Ring Complex
Golgi-derived microtubules constitute an asymmetrical microtubule network that drives polarized transport of vesicles to support cell polarization...
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Assessment and Modelling of Forest Biomass and Carbon Stock and Sequestration Using Various Remote Sensing Sensor Systems
The global climatic crisis along with the threat to the forests has increased the need to research for more accurate and accessible methods and...
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Characterization of caffeoyl shikimate esterase gene family identifies CsCSE5 as a positive regulator of Podosphaera xanthii and Corynespora cassiicola pathogen resistance in cucumber
Key messageCsCSE genes might be involved in the tolerance of cucumber to pathogens. Silencing of the CsCSE5 gene resulted in attenuated resistance...
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Global research trends on aquaponics: a systematic review based on computational map**
Aquaponics is an integrated fish and crop production system that includes aquaculture and hydroponics. The purpose of this study was to assess...
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Forest fire, thinning, and flood in wildland-urban interface: UAV and lidar-based estimate of natural disaster impacts
ContextWildland-urban interface (WUI) areas are facing increased forest fire risks and extreme precipitation events due to climate change, which can...
