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The new seriniquinone glycoside by biological transformation using the deep sea-derived bacterium Bacillus licheniformis KDM612
Seriniquinone was isolated as a melanoma-selective anti-cancer agent from a culture broth of the marine-derived bacterium Serinicoccus marinus CNJ927...
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Amyloid modifier SERF1a interacts with polyQ-expanded huntingtin-exon 1 via helical interactions and exacerbates polyQ-induced toxicity
Abnormal polyglutamine (polyQ) expansion and fibrillization occur in Huntington’s disease (HD). Amyloid modifier SERF enhances amyloid formation, but...
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Z-DNA and Z-RNA: Methods—Past and Future
A quote attributed to Yogi Berra makes the observation that “It’s tough to make predictions, especially about the future,” highlighting the...
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NMR Analysis of the Interactions and Conformational Plasticity of Dynein Intermediate Chain
Cytoplasmic dynein complexes play crucial roles in intracellular transport of cellular organelles. While the motor domain of dynein is well...
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Binding and stabilizating effect of RNA triplex poly(U)⋅poly(A)*poly(U) by enantiomers of ruthenium(II) polypyridyl complex [Ru(bpy)2(dppx)]2+
Two chiral ruthenium(II) polypyridyl complexes, Λ-[Ru(bpy) 2 (dppx)] 2+ (bpy = 2,2′-bipyridine, dppx = 7,8-dimethyldipyridophenazine; Λ- 1 ) and Δ-[Ru(bpy)
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Evolutionary fine-tuning of residual helix structure in disordered proteins manifests in complex structure and lifetime
Transcription depends on complex networks, where folded hub proteins interact with intrinsically disordered transcription factors undergoing coupled...
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Soils potentially vulnerable to phosphorus losses: speciation of inorganic and organic phosphorus and estimation of leaching losses
Eutrophication is an important threat to aquatic ecosystems world-wide, and reliable identification of areas vulnerable to phosphorus (P) losses from...
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Acidophilic structure and killing mechanism of the Pichia farinosa killer toxin SMKT
SMKT, a killer toxin produced by a halotolerant yeast Pichia farinosa that consists of α and β subunits, is generated from a chromosomally encoded...
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Plant Phosphorus Efficiency from Raw and Composted Agro- and Bio-Waste Anaerobic Digestates
The rising generation of organic waste (OW) can be a concern, representing at the same time a valuable opportunity for the phosphorous (P) recycling;...
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Specialized metabolites of the genus Zephyranthes Herb.: a critical review on taxonomy and phytochemistry
This article is a critical review of the taxonomy and phytochemistry of the genus Zephyranthes Herb., a group of plants known for their beautiful...
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An atypical RNA quadruplex marks RNAs as vectors for gene silencing
The addition of poly(UG) (‘pUG’) repeats to 3′ termini of mRNAs drives gene silencing and transgenerational epigenetic inheritance in the metazoan Caen...
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Four new chromone derivatives from the Arctic fungus Phoma muscivora CPCC 401424 and their antiviral activities
The crude extract of the Arctic fungus Phoma muscivora CPCC 401424 displayed anti-influenza A virus activities which led us to investigated their...
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A new polycyclic tetramate macrolactam from Allostreptomyces RD068384: stereochemistry and antifungal potential
A new polycyclic tetramate macrolactam designated allostreptamide ( 1 ), together with four known congeners, were isolated from the culture extract of Allostreptomyces...
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Trichoderma Mediated Metal Chelator and Its Role in Solanum melongena Growth Under Heavy Metals
The current research has been conceptualized to see the impact of Trichoderma harzianum synthesized siderophore in alleviation of heavy metal stress...
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Insights into the xylan degradation system of Cellulomonas sp. B6: biochemical characterization of rCsXyn10A and rCsAbf62A
AbstractValorization of the hemicellulose fraction of plant biomass is crucial for the sustainability of lignocellulosic biorefineries. The Cellulomonas...
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Abnormal proliferation of gut mycobiota contributes to the aggravation of Type 2 diabetes
Type 2 diabetes (T2D) constitutes a worldwide health threat, and the underlying mechanism for the development and progression of T2D is complex and...
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A potentiometric and spectrofluorimetric approach to unravel inhibitory effects of semi- and thiosemicarbazones on mushroom tyrosinase activity
The inhibitory effects on mushrooms tyrosinase activity of some semi- and thiosemicarbazones were investigated. While the semicarbazones are...
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A Review of the in Silico Design and Development Approaches of Ras-Specific Anticancer Therapeutics
Ras Proteins, play a pivotal role in the proliferation pathways, and Ras mutant forms are well-established cancer drivers. Ras mutations are found in...
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Efficient production of 14α-OH-AD by engineered Mycolicibacterium neoaurum via coupled cofactor and reconstructed electron transport system
14α-hydroxy-androst-4-ene-3,17-dione (14α-OH-AD) is an important precursor for the synthesis of steroid drugs with anti-cancer and carcinolytic...
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Structural characterization of carboxyatractyloside and acaricidal activity of natural ent-kaurene diterpenoids isolated from Chamaeleon gummifer against Tetranychus urticae
Plant-borne secondary metabolites are attracting high interest for their potential use in agricultural applications, with special reference to the...
