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Effects of S-glutathionylation on the passive force–length relationship in skeletal muscle fibres of rats and humans
This study investigated the effect of S -glutathionylation on passive force in skeletal muscle fibres, to determine whether activity-related redox...
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Skeletal Muscle Formation, Regeneration, and Recovery from Injury
In this chapter, we embark on a journey through the remarkable world of skeletal muscle formation, regeneration, and recovery from injury. Skeletal...
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Cyclic Stretching Induces Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes through Nuclear-Mechanotransduction
Background:During cardiogenesis, cardiac cells receive various stimuli, such as biomechanical and chemical cues, from the surrounding...
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Through thick and thin: dual regulation of insect flight muscle and cardiac muscle compared
Both insect flight muscle and cardiac muscle contract rhythmically, but the way in which repetitive contractions are controlled is different in the...
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Spatiotemporal transcriptome analysis reveals critical roles for mechano-sensing genes at the border zone in remodeling after myocardial infarction
The underlying mechanisms of ventricular remodeling after myocardial infarction (MI) remain largely unknown. In this study, we performed an...
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Elamipretide (SS-31) treatment attenuates age-associated post-translational modifications of heart proteins
It has been demonstrated that elamipretide (SS-31) rescues age-related functional deficits in the heart but the full set of mechanisms behind this...
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Effect of xylazine sedation on testicular blood flow, testicular echotexture, and circulating hormones in Shiba goats
Under field conditions, sedation may be required for a full assessment of the reproductive potential of farm animals. The present study aimed to...
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Time-regulated transcripts with the potential to modulate human pluripotent stem cell-derived cardiomyocyte differentiation
BackgroundHuman-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are a promising disease model, even though hiPSC-CMs cultured for...
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Response and Effects of Cardiomyocyte Progenitors in the Infarcted Heart
Several studies indicate that endogenous cardiac progenitorCardiac progenitors cells (CPCs) play some role in homeostasis and response to ischemic...
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Muscle growth and plasticity in teleost fish: the significance of evolutionarily diverse sarcomeric proteins
The skeletal muscle of teleost fish is remarkable in its capacity for indeterminate growth and phenotypic plasticity to function across different...
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Preservation of shortening velocity and power output in single muscle fibres from patients with idiopathic inflammatory myopathies
Idiopathic inflammatory myopathies (IIMs) are autoimmune disorders of skeletal muscle causing weakness and disability. Utilizing single fibre...
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Chronic Ethanol Exposure Induces Deleterious Changes in Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells
Chronic alcohol consumption in adults can induce cardiomyopathy, arrhythmias, and heart failure. In newborns, prenatal alcohol exposure can increase...
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Maturity of Pluripotent Stem Cell-Derived Cardiomyocytes and Future Perspectives for Regenerative Medicine
Pluripotent stem cell-derived cardiomyocytes (PSC-CMs) have numerous potential for the source of cardiomyocytes to replace dead cells in heart...
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Binding Proteins
This chapter pivots to the microscopic world of skeletal muscle-binding proteins—these molecular powerhouses that perform many tasks essential to the...
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The complexity of titin splicing pattern in human adult skeletal muscles
BackgroundMutations in the titin gene ( TTN ) cause a large spectrum of diseases affecting skeletal and/or cardiac muscle. TTN includes 363 coding...
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Genetic and environmental determinants of diastolic heart function
Diastole is the sequence of physiological events that occur in the heart during ventricular filling and principally depends on myocardial relaxation...
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The p.Ala2430Val mutation in filamin C causes a "hypertrophic myofibrillar cardiomyopathy"
Hypertrophic cardiomyopathy (HCM) often leads to heart failure. Mutations in sarcomeric proteins are most frequently the cause of HCM but in many...
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Comprehensive analysis of geographic and breed-purpose influences on genetic diversity and inherited disease risk in the Doberman dog breed
BackgroundPublicly available phenotype data and genoty** array data from two citizen science projects: “Doberman Health Surveys” and “The Doberman...
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Sequelae of Genetic Defects in Cardiomyocytes
The consequences of geneticGenetics defects in cardiomyocytesCardiomyocyte are congenital heart defectsCongenital heart defects or inherited...
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Modeling hypertrophic cardiomyopathy with human cardiomyocytes derived from induced pluripotent stem cells
One of the obstacles in studying the pathogenesis of hypertrophic cardiomyopathy (HCM) is the poor availability of myocardial tissue samples at the...