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Mining of a streptothricin gene cluster from Streptomyces sp. TP-A0356 genome via heterologous expression
Streptothricins (STs) are used commercially to treat bacterial and fungal diseases in agriculture. Mining of the sequenced microbial genomes...
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Identification of the SGR6065 gene product as a sesquiterpene cyclase involved in (+)-epicubenol biosynthesis in Streptomyces griseus
Recent bacterial genome sequencing projects have shown the presence of many putative sesquiterpene cyclase (SC) genes, especially in the...
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Characterization of a new ScbR-like γ-butyrolactone binding regulator (SlbR) in Streptomyces coelicolor
γ-Butyrolactones in Streptomyces are well recognized as bacterial hormones, and they affect secondary metabolism of Streptomyces . γ-Butyrolactone...
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Marriage patterns in the Western French Pyrenees during the 1800–1899 period: data from the village of Béost (Ossau Valley, Béarn)
The Western Pyrenees are made up of isolated valleys that were associated until recently with low marriage mobility. We chose to study the Ossau...
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Bacterial Pharmaceutical Products
Bacterial pharmaceutical products include antibiotics, antitumor agents, immunomodulators, and enzyme inhibitors. Other bioactive products of...
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Towards a new science of secondary metabolism
Secondary metabolites are a reliable and very important source of medicinal compounds. While these molecules have been mined extensively, genome...
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Genome plasticity and systems evolution in Streptomyces
BackgroundStreptomycetes are filamentous soil-dwelling bacteria. They are best known as the producers of a great variety of natural products such as...
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Transcriptional regulation and increased production of asukamycin in engineered Streptomyces nodosus subsp. asukaensis strains
Asukamycin, a member of the manumycin family of antibiotics, exhibits strong antibacterial, antifungal, and antineoplastic activities. However, its...
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Biosynthesis of clavam metabolites
Naturally occurring clavam metabolites include the valuable β-lactamase inhibitor, clavulanic acid, as well as stereochemical variants with...
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The Family Rhodospirillaceae
Rhodospirillaceae Pfennig and Trüper 1971, 17AL Rhodospirillaceae are a family within the order Rhodospirillales in the subclass of...
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Electrochemical Detection of Harmful Algae by Means of a Sandwich Hybridization Assay on an Electrode Surface
We report on the development of a sandwich hybridization assay on an electrode surface-based sensor device for the detection of toxic algae. This DNA...
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Characterization of Sgr3394 produced only by the A-factor-producin Streptomyces griseus IFO 13350, not by the A-factor deficient mutant
Protein D (9.7 kDa) is an extracellular protein detected in the culture broth of A-factor-producing Streptomyces griseus IFO 13350, but not of the...
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Insights into dynein motor domain function from a 3.3-Å crystal structure
Dyneins power the beating of cilia and flagella, transport various intracellular cargos and are necessary for mitosis. All dyneins have a ∼300-kDa...
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SabR enhances nikkomycin production via regulating the transcriptional level of sanG, a pathway-specific regulatory gene in Streptomyces ansochromogenes
BackgroundsabR is a pleiotropic regulatory gene which has been shown to positively regulate the nikkomycin biosynthesis and negatively affect the...
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Methods for reactive oxygen species (ROS) detection in aqueous environments
This review summarizes direct and indirect analytical methods for the detection and quantification of the reactive oxygen species (ROS): 1 O 2 , O
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Expression of a polycistronic messenger RNA involved in antibiotic production in an rnc mutant of Streptomyces coelicolor
RNase III is a double strand specific endoribonuclease that is involved in the regulation of gene expression in bacteria. In Streptomyces coelicolor ,...
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The biosynthesis of the polyether antibiotic nanchangmycin is controlled by two pathway-specific transcriptional activators
The nanchangmycin (NAN) produced by Streptomyces nanchangensis NS3226 is a polyether antibiotic resembling monensin in their gene clusters and the...
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Characterization of the European type of maternal lineage evident in extant Jeju native pigs
Using a partial D-loop sequence of mtDNA, an intensive analysis was conducted of the maternal lineages of Jeju native pigs (JNPs) from Korea. In...
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A novel function of Streptomyces integration host factor (sIHF) in the control of antibiotic production and sporulation in Streptomyces coelicolor
Bacterial integration host factors (IHFs) play important roles in site-specific recombination, DNA replication, transcription, genome organization...
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The PII protein GlnK is a pleiotropic regulator for morphological differentiation and secondary metabolism in Streptomyces coelicolor
GlnK is an important nitrogen sensor protein in Streptomyces coelicolor. Deletion of glnK results in a medium-dependent failure of aerial mycelium...
