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Reg4 deficiency aggravates pancreatitis by increasing mitochondrial cell death and fibrosis
Regenerating gene family member 4 ( Reg4 ) has been implicated in acute pancreatitis, but its precise functions and involved mechanisms have remained...
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Deubiquitinating enzymes: potential regulators of the tumor microenvironment and implications for immune evasion
Ubiquitination and deubiquitination are important forms of posttranslational modification that govern protein homeostasis. Deubiquitinating enzymes...
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The Impact of Chronic Magnesium Deficiency on Excitable Tissues—Translational Aspects
Neuromuscular excitability is a vital body function, and Mg 2+ is an essential regulatory cation for the function of excitable membranes. Loss of Mg 2+ ...
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Immune evasion impacts the landscape of driver genes during cancer evolution
BackgroundCarcinogenesis is driven by interactions between genetic mutations and the local tumor microenvironment. Recent research has identified...
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Association of Probiotics and Prebiotics with Human Microbiome and the Functioning of Immune System
The evolution of mutualism and homeostasis between mammals and their commensal microorganisms makes sense from an ecological perspective. Microbiota...
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Transcriptomics and metabolomics analysis reveal the dietary copper deficiency and supplementation effects of liver gene expression and metabolite change in grazing sheep
BackgroundThe appropriate mineral nutrients are essential for sheep growth and reproduction. However, traditional grazing sheep often experience...
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JAK/STAT mediated insulin resistance in muscles is essential for effective immune response
BackgroundThe metabolically demanding nature of immune response requires nutrients to be preferentially directed towards the immune system at the...
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Zinc Deficiency as a General Feature of Cancer: a Review of the Literature
Trace elements are minerals that are present in very low concentrations in the human body and yet are crucial for a wide range of physiological...
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GSDME deficiency leads to the aggravation of UVB-induced skin inflammation through enhancing recruitment and activation of neutrophils
Gasdermin E (GSDME)-mediated pyroptosis is induced in keratinocytes of UVB-challenged skin. The role of GSDME in UVB-caused skin damage remains...
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A primary luminal/HER2 negative breast cancer patient with mismatch repair deficiency
Here, we present the case of a 47-year-old woman diagnosed with luminal B breast cancer subtype and provide an in-depth analysis of her gene...
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Atg5 deficiency in macrophages protects against kidney fibrosis via the CCR6-CCL20 axis
BackgroundAutophagy is a lysosome-dependent degradation pathway that regulates macrophage activation, differentiation, and polarization. Autophagy...
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ERRFI1 induces apoptosis of hepatocellular carcinoma cells in response to tryptophan deficiency
Tryptophan metabolism is an essential regulator of tumor immune evasion. However, the effect of tryptophan metabolism on cancer cells remains largely...
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Effect of nonsense-mediated mRNA decay factor SMG9 deficiency on premature aging in zebrafish
SMG9 is an essential component of the nonsense-mediated mRNA decay (NMD) machinery, a quality control mechanism that selectively degrades aberrant...
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S100A8/A9hi neutrophils induce mitochondrial dysfunction and PANoptosis in endothelial cells via mitochondrial complex I deficiency during sepsis
S100a8/a9, largely released by polymorphonuclear neutrophils (PMNs), belongs to the S100 family of calcium-binding proteins and plays a role in a...
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The bone–liver interaction modulates immune and hematopoietic function through Pinch-Cxcl12-Mbl2 pathway
Mesenchymal stromal cells (MSCs) are used to treat infectious and immune diseases and disorders; however, its mechanism(s) remain incompletely...
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Usp14 deficiency removes α-synuclein by regulating S100A8/A9 in Parkinson’s disease
Ubiquitin-proteasome system dysfunction triggers α-synuclein aggregation, a hallmark of neurodegenerative diseases, such as Parkinson’s disease (PD)....
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Kinome and phosphoproteome reprogramming underlies the aberrant immune responses in critically ill COVID-19 patients
SARS-CoV-2 infection triggers extensive host immune reactions, leading to severe diseases in certain individuals. However, the molecular basis...
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Clinical manifestations and immune response to tuberculosis
Tuberculosis is a far-reaching, high-impact disease. It is among the top ten causes of death worldwide caused by a single infectious agent; 1.6...
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SerpinB7 deficiency contributes to development of psoriasis via calcium-mediated keratinocyte differentiation dysfunction
Defective execution of proteases and protease inhibitors that mediate abnormal signaling cascades is emerging as a key contributor to skin diseases,...
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Screening of primary open-angle glaucoma diagnostic markers based on immune-related genes and immune infiltration
PurposePrimary open-angle glaucoma (POAG) continues to be a poorly understood disease. Although there were multiple researches on the identification...
