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Chitosan hydrogel-loaded MSC-derived extracellular vesicles promote skin rejuvenation by ameliorating the senescence of dermal fibroblasts
BackgroundThe senescence of dermal fibroblasts (DFLs) leads to an imbalance in the synthesis and degradation of extracellular matrix (ECM) proteins,...
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Extracorporeal Shock Wave Combined with Teriparatide-Loaded Hydrogel Injection Promotes Segmental Bone Defects Healing in Osteoporosis
BACKGROUND: Osteoporosis is a systemic bone disease characterized by decreased bone density and deterioration of bone microstructure, leading to an...
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Frame-Hydrogel Methodology for Engineering Highly Functional Cardiac Tissue Constructs
Engineered cardiac tissues hold tremendous promise for in vitro drug discovery, studies of heart development and disease, and therapeutic... -
Comparison Capacity of Collagen Hydrogel and Collagen/Strontium Bioglass Nanocomposite Scaffolds With and Without mesenchymal Stem Cells in Regeneration of Critical Sized Bone Defect in a Rabbit Animal Model
Bone self-healing is limited and requires additional or external intervention to promote and accelerate bone regeneration. Therefore, the aim of this...
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In vivo evaluation of a recombinant N-acylhomoserine lactonase formulated in a hydrogel using a murine model infected with MDR Pseudomonas aeruginosa clinical isolate, CCASUP2
Failure in the treatment of P. aeruginosa, due to its broad spectrum of resistance, has been associated with increased patient mortality. One...
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RETRACTED ARTICLE: Myocardial ischemia reperfusion injury is alleviated by curcumin-peptide hydrogel via upregulating autophagy and protecting mitochondrial function
BackgroundIschemia-reperfusion injury (IRI) is an important factor limiting the success of cardiac reperfusion therapy. Curcumin has a significant...
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Combination of lyophilized adipose-derived stem cell concentrated conditioned medium and polysaccharide hydrogel in the inhibition of hypertrophic scarring
BackgroundMesenchymal stem cell-based acellular therapies have been widely exploited in managing hypertrophic scars. However, low maintenance dose...
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Short Review on Advances in Hydrogel-Based Drug Delivery Strategies for Cancer Immunotherapy
Cancer immunotherapy has become the new paradigm of cancer treatment. The introduction and discovery of various therapeutic agents have also...
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Wharton’s jelly mesenchymal stem cells embedded in PF-127 hydrogel plus sodium ascorbyl phosphate combination promote diabetic wound healing in type 2 diabetic rat
BackgroundDiabetic cutaneous ulcers (DCU) are a complication of diabetes with diabetic foot ulcers being the most common, and the wounds are...
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GD2-specific CAR T cells encapsulated in an injectable hydrogel control retinoblastoma and preserve vision
Retinoblastoma (RB) is a pediatric retinal tumor that overexpresses the ganglioside GD2. Although it is treatable in patients with early diagnosis,...
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Making bioinspired 3D-printed autonomic perspiring hydrogel actuators
To mitigate the adverse effects of elevated temperatures, conventional rigid devices use bulky radiators, heat sinks and fans to dissipate heat from...
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Bone regeneration in rat calvarial defects using dissociated or spheroid mesenchymal stromal cells in scaffold-hydrogel constructs
BackgroundThree-dimensional (3D) spheroid culture can promote the osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSC). 3D...
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Combinatorial therapy of chitosan hydrogel-based zinc oxide nanocomposite attenuates the virulence of Streptococcus mutans
BackgroundBiofilm formation is an important causative factor in the expansion of the carious lesions in the enamel. Hence, new approaches to...
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A Sequential Culturing System for Generating Epithelial-Like Stem Cells from Human Mesenchymal Stem Cells Derived from Adipose Tissue
AbstractSkin burn repair requires efficient regeneration in order to achieve proper healing. We applied a sequential culturing system 2D1w/3D2w...
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A nanocomposite hydrogel delivery system for mesenchymal stromal cell secretome
BackgroundMesenchymal stromal cell conditioned medium (MSC-CM) contains a cocktail of bioactive factors that act synergistically to induce...
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miR-126-3p-loaded small extracellular vesicles secreted by urine-derived stem cells released from a phototriggered imine crosslink hydrogel could enhance vaginal epithelization after vaginoplasty
BackgroundDue to the large area and deep width of the artificial neovagina after vaginoplasty, it takes a considerable amount of time to achieve...
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Funktionale Hydrogele in mikrofluidischen Nanoreaktoren
The developments of microfluidics and hydrogels are strongly linked to one another. Small micrometer-sized hydrogels, so-called hydrogel-dots, can be...
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Eco-friendly cellulose-based hydrogels derived from wastepapers as a controlled-release fertilizer
In this study, an eco-friendly controlled release fertilizer cellulose-based hydrogel was prepared from cellulose fibers derived from wastepaper,...