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Female aging: when translational models don’t translate
For many pathologies associated with aging, female patients present with higher morbidity and more frequent adverse events from treatments compared...
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The Chemistry of Antidiabetic Plants
A great many plant species that demonstrate activity against hyperglycemia are listed in literature. They are known to contain classes of compounds...
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Inhibition of STIM1 alleviates high glucose-induced proliferation and fibrosis by inducing autophagy in mesangial cells
Diabetic nephropathy (DN) is a renal microvascular complication caused by diabetes mellitus. One of the most typical characteristics of DN is...
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Learning consistent subcellular landmarks to quantify changes in multiplexed protein maps
Highly multiplexed imaging holds enormous promise for understanding how spatial context shapes the activity of the genome and its products at...
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Zinc Ameliorates Tripterygium Glycosides–Induced Reproductive Impairment in Male Rats by Regulating Zinc Homeostasis and Expression of Oxidative Stress–Related Genes
Tripterygium glycosides (TG) can seriously damage male reproductive function, and the reproductive system is difficult to restore after stop** the...
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Application of Transcriptomics in Exploring Important Genes in Medicinal Plants
The medicinal properties of plant species have significantly contributed to the development of various herbal therapies for a variety of diseases...
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Targeting the Lnc-OPHN1-5/androgen receptor/hnRNPA1 complex increases Enzalutamide sensitivity to better suppress prostate cancer progression
Long non-coding RNAs (lncRNAs) have been found to play critical roles in regulating gene expression, but their function in translational control is...
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Multi-Omics Approaches for Breeding in Medicinal Plants
Over the last few eras, multi-omics has been a successful technique for medicinal plants. All over the medicinal plants have been operated in...
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Nontuberculous Mycobacterium Infections in Lung Disease and Medical Interventions
Infection with nontuberculous mycobacteria (NTM) is on the rise all across the world. Lung disease due to NTM is more prevalent and frequent and is...
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Exploration of the molecular mechanism of tea polyphenols against pulmonary hypertension by integrative approach of network pharmacology, molecular docking, and experimental verification
Pulmonary hypertension, a common complication of chronic obstructive pulmonary disease, is a major global health concern. Green tea is a popular...
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Kethoxal-assisted single-stranded DNA sequencing captures global transcription dynamics and enhancer activity in situ
Transcription is a highly dynamic process that generates single-stranded DNA (ssDNA) in the genome as ‘transcription bubbles’. Here we describe a...
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An integrative analysis of enhancer of yellow 2 homolog (ENY2) as a molecular biomarker in pan-cancer
ENY2 (Enhancer of yellow 2 transcription factor) is a transcription nuclear protein and primarily participates in the course of mRNA export and...
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Microbiota Targeted Via Nanotechnology for Lung Cancer Therapy: Challenges and Future Perspectives
Lung cancer is the foremost reason of cancer associated deaths globally and poses a great threat to human health. It has become progressively clear...
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Nature-inspired male contraceptive and spermicidal products
The use of hazardous female contraceptives is still the first choice in family planning programs. Moreover, all the drugs examined to be used as...
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Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a prominent extracellular matrix (ECM) deposition and poor prognosis. High levels of...
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Akt-GSK3β-mPTP pathway regulates the mitochondrial dysfunction contributing to odontoblasts apoptosis induced by glucose oxidative stress
Diabetes Mellitus can cause dental pulp cells apoptosis by oxidative stress, and affect the integrity and function of dental pulp tissue....
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Full-Length Transcript Sequencing and Comparative Transcriptomic Analysis of Paeonia lactiflora Reveals Tissue- and Ecotype-Specific Expression of Paeoniflorin Biosynthesis-Related Genes
Paeonia lactiflora Pall., a Paeoniaceae family member, is a herbaceous perennial flower of significant horticultural importance. It holds prominence...
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Screening of phytochemicals effective on relieving cancer cachexia in cisplatin-induced in vitro sarcopenia model
BackgroundCancer cachexia is a lethal metabolic syndrome induced by cancer and chemotherapy administration and characterized by marked muscle...
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Common mechanisms underlying diabetic vascular complications: focus on the interaction of metabolic disorders, immuno-inflammation, and endothelial dysfunction
Diabetic vascular complications (DVCs), including macro- and micro- angiopathy, account for a high percentage of mortality in patients with diabetes...
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HIV cure strategies: which ones are appropriate for Africa?
Although combination antiretroviral therapy (ART) has reduced mortality and improved lifespan for people living with HIV, it does not provide a cure....
