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Integrative insights and clinical applications of single-cell sequencing in cancer immunotherapy
Recently, immunotherapy has gained increasing popularity in oncology. Several immunotherapies obtained remarkable clinical effects, but the efficacy...
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Next-Generation Sequencing in Medicinal Plants: Recent Progress, Opportunities, and Challenges
Medicinal plants have a significant role in human health care since the development of medicine. Plants that yield phytopharmaceuticals have produced...
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Transcriptomic variations associated with salinity stress in Penaeus indicus
BackgroundThe Indian white shrimp, Penaeus indicus a native species of India, is important brackishwater aquaculture species. Shrimps are euryhaline...
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Elucidating the role of exogenous melatonin in mitigating alkaline stress in soybeans across different growth stages: a transcriptomic and metabolomic approach
BackgroundSoybean ( Glycine max ), a vital grain and oilseed crop, serves as a primary source of plant protein and oil. Soil salinization poses a...
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Regulation of endocrine cell alternative splicing revealed by single-cell RNA sequencing in type 2 diabetes pathogenesis
The prevalent RNA alternative splicing (AS) contributes to molecular diversity, which has been demonstrated in cellular function regulation and...
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Transcriptomic Analysis During the Induction of Somatic Embryogenesis in Coffea canephora
Omic tools have changed the way of doing research in experimental biology. The somatic embryogenesis (SE) study has not been immune to this benefit....
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Transcriptomic and physiological analysis reveal phytohormone and phenylpropanoid biosynthesis in root of Cynanchum auriculatum
Baishouwu ( Cynanchum auriculatum ), a medicinal and food dual-use plant, has been cultivated for centuries and is favored by consumers. C. auriculatum ...
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A cell transcriptomic profile provides insights into adipocytes of porcine mammary gland across development
BackgroundStudying the composition and developmental mechanisms in mammary gland is crucial for healthy growth of newborns. The mammary gland is...
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A vein wall cell atlas of murine venous thrombosis determined by single-cell RNA sequencing
Deep vein thrombosis (DVT) is a common clinical problem, but its cellular and molecular mechanisms remain incompletely understood. In this study, we...
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Integrative and comparative single-cell analysis reveals transcriptomic difference between human tumefactive demyelinating lesion and glioma
Tumefactive demyelinating lesion (TDL) is an immune-mediated disease which can be misdiagnosed as glioma. At present, there is no study comparing...
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Generation and transcriptomic characterization of MIR137 knockout miniature pig model for neurodevelopmental disorders
BackgroundNeurodevelopmental disorders (NDD), such as autism spectrum disorders (ASD) and intellectual disorders (ID), are highly debilitating...
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Development of SNP and InDel markers by genome resequencing and transcriptome sequencing in radish (Raphanus sativus L.)
BackgroundSingle nucleotide polymorphisms (SNPs) and insertions/deletions (InDels) are the most abundant genetic variations and widely distribute...
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Characterizing immune variation and diagnostic indicators of preeclampsia by single-cell RNA sequencing and machine learning
Preeclampsia is a multifactorial and heterogeneous complication of pregnancy. Here, we utilize single-cell RNA sequencing to dissect the involvement...
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Regulation of the methanogenesis pathways by hydrogen at transcriptomic level in time
AbstractThe biomethane formation from 4 H 2 + CO 2 by pure cultures of two methanogens, Methanocaldococcus fervens and Methanobacterium thermophilum ,...
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Metabolomic and transcriptomic analyses highlight metabolic regulatory networks of Salvia miltiorrhiza in response to replant disease
BackgroundSalvia miltiorrhiza , a well-known traditional Chinese medicine, frequently suffers from replant diseases that adversely affect its quality...
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Genetic Engineering Approaches for Haematococcus: Recent Developments in Genome Sequencing and Strain Improvement
Haematococcus is one of the most outstanding microalgal species, which has been mainly considered for the large-scale production of astaxanthin....
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Pathological observation and transcriptomic analysis of thymus injury in PRRSV-infected piglets
The thymus, the central immune organ in mammals, plays an important role in immune defense. Porcine reproductive and respiratory syndrome virus...
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Single-cell sequencing advances in research on mesenchymal stem/stromal cells
Mesenchymal stem/stromal cells (MSCs), originating from the mesoderm, represent a multifunctional stem cell population capable of differentiating...
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Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1
Limited understanding exists regarding how aging impacts the cellular and molecular aspects of the human ovary. This study combines single-cell RNA...
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Integrated transcriptomic and metabolomic analysis provides insights into cold tolerance in lettuce (Lactuca sativa L.)
The popular leafy vegetable lettuce ( Lactuca sativa L.) is susceptible to cold stress during the growing season, which slows growth rate, causes leaf...
