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Single cell epigenomic and transcriptomic analysis uncovers potential transcription factors regulating mitotic/meiotic switch
In order to reveal the complex mechanism governing the mitotic/meiotic switch in female germ cells at epigenomic and genomic levels, we examined the...
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Hypes and Hopes of Stem Cell Therapies in Dentistry: a Review
One of the most exciting advances in life science research is the development of 3D cell culture systems to obtain complex structures called...
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Pervasive male-biased expression throughout the germline-specific regions of the sea lamprey genome supports key roles in sex differentiation and spermatogenesis
Sea lamprey undergo programmed genome rearrangement (PGR) in which ∼20% of the genome is jettisoned from somatic cells during embryogenesis. Although...
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Single-cell RNA sequencing reveals regulation of fetal ovary development in the monkey (Macaca fascicularis)
Germ cells are vital for reproduction and heredity. However, the mechanisms underlying female germ cell development in primates, especially in late...
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Effect of genomic X-chromosome regions on Nelore bull fertility
Scrotal circumference (SC) is a commonly used trait related to sexual precocity in bulls. Genome-wide association studies have uncovered a lot of...
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Heterogeneity of Stem Cells in the Ovary
Every organ in the body is thought to harbor two populations of stem cells, including the quiescent and the actively dividing, that leads to...
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Granulosa cell mevalonate pathway abnormalities contribute to oocyte meiotic defects and aneuploidy
With aging, abnormalities during oocyte meiosis become more prevalent. However, the mechanisms of aging-related oocyte aneuploidy are not fully...
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Emerging roles and functional mechanisms of PIWI-interacting RNAs
PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with proteins of the PIWI clade of the Argonaute family. First...
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GSK-3β protects fetal oocytes from premature death via modulating TAp63 expression in mice
BackgroundFemale mammals have a limited reproductive lifespan determined by the size of the primordial follicle pool established perinatally. Over...
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Comparative transcriptomic analysis of reproductive characteristics of reciprocal hybrid lineages derived from hybridization between Megalobrama amblycephala and Culter alburnus
BackgroundDistant hybridization is an important breeding technique for creating new strains with superior traits by integrating two different...
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Genome-wide association study identifies genomic regions associated with key reproductive traits in Korean Hanwoo cows
BackgroundConducting genome-wide association studies (GWAS) for reproductive traits in Hanwoo cattle, including age at first calving (AFC), calving...
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Self-organising human gonads generated by a Matrigel-based gradient system
BackgroundAdvances in three-dimensional culture technologies have led to progression in systems used to model the gonadal microenvironment in vitro....
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Differential expression analysis and identification of sex-related genes by gonad transcriptome sequencing in estradiol-treated and non-treated Ussuri catfish Pseudobagrus ussuriensis
The Ussuri catfish ( Pseudobagrus ussuriensis ) has an XX/XY sex determination system but its sex determination gene(s) remain unknown. To better...
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Germline specification and axis determination in viviparous and oviparous pea aphids: conserved and divergent features
Aphids are hemimetabolous insects that undergo incomplete metamorphosis without pupation. The annual life cycle of most aphids includes both an...
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The killifish germline regulates longevity and somatic repair in a sex-specific manner
Classical evolutionary theories propose tradeoffs among reproduction, damage repair and lifespan. However, the specific role of the germline in...
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Proteome and Transcriptome Analysis of Gonads Reveals Intersex in Gigantidas haimaensis
Sex has proven to be one of the most intriguing areas of research across evolution, development, and ecology. Intersex or sex change occurs...
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Rat PRDM9 shapes recombination landscapes, duration of meiosis, gametogenesis, and age of fertility
BackgroundVertebrate meiotic recombination events are concentrated in regions (hotspots) that display open chromatin marks, such as trimethylation of...
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Ovarian ERβ cistrome and transcriptome reveal chromatin interaction with LRH-1
BackgroundEstrogen receptor beta (ERβ, Esr2) plays a pivotal role in folliculogenesis and ovulation, yet its exact mechanism of action is mainly...
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Comparative transcriptomic analysis of the different developmental stages of ovary in red swamp crayfish Procambarus clarkii
BackgroundThe red swamp crayfish Procambarus clarkii is a freshwater species that possesses high adaptability, environmental tolerance, and...
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Integrin signaling in cancer: bidirectional mechanisms and therapeutic opportunities
Integrins are transmembrane receptors that possess distinct ligand-binding specificities in the extracellular domain and signaling properties in the...
