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The efficacy of machine learning algorithm for raw drug authentication in Coscinium fenestratum (Gaertn.) Colebr. employing a DNA barcode database
Medicinal plants are a valuable resource for traditional as well as modern medicine. Consequently huge demand has exerted a heavy strain on the...
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The Clinical Effectiveness of Denosumab (Prolia®) for the Treatment of Osteoporosis in Postmenopausal Women, Compared to Bisphosphonates, Selective Estrogen Receptor Modulators (SERM), and Placebo: A Systematic Review and Network Meta-Analysis
To assess the effectiveness and safety of denosumab (Prolia®) compared to bisphosphonates (alendronate, ibandronate, risedronate, zoledronate),...
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Favipiravir treatment does not influence disease progression among adult patients hospitalized with moderate-to-severe COVID-19: a prospective, sequential cohort study from Hungary
Data suggests that favipiravir (FVP) could be used against SARS-CoV-2. Our aim was to investigate the role of FVP in COVID-19 treatment. A...
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Catharanthus Roseus: A Source of Anticancer Phytomedicines
Catharanthus rosesus, widely known as the Madagascar periwinkle and the Cape periwinkle, is a flowering plant believed to have potent medicinal and...
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Deep learning-enabled natural language processing to identify directional pharmacokinetic drug–drug interactions
BackgroundDuring drug development, it is essential to gather information about the change of clinical exposure of a drug (object) due to the...
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Medicinal Plants in the Indian Traditional Medicine and Current Practices
Plants have been emphasized in traditional medicine since 2600 BCE. Traditional medicine has been accessible to millions of people worldwide and are...
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A sui generis QA approach using RoBERTa for adverse drug event identification
BackgroundExtraction of adverse drug events from biomedical literature and other textual data is an important component to monitor drug-safety and...
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Anti-SARS-CoV-2 antibody-containing plasma improves outcome in patients with hematologic or solid cancer and severe COVID-19: a randomized clinical trial
Patients with cancer are at high risk of severe coronavirus disease 2019 (COVID-19), with high morbidity and mortality. Furthermore, impaired humoral...
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Text Mining Protocol to Retrieve Significant Drug–Gene Interactions from PubMed Abstracts
Genes and proteins form the basis of all cellular processes and ensure a smooth functioning of the human system. The diseases caused in humans can be...
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A Text Mining Protocol for Extracting Drug–Drug Interaction and Adverse Drug Reactions Specific to Patient Population, Pharmacokinetics, Pharmacodynamics, and Disease
Drug-drug interactions (DDIs) and adverse drug reactions (ADR) are experienced by many patients, especially by elderly population due to their...
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Marketing Regulatory Oversight of Advanced Therapy Medicinal Products in Europe
Advanced therapy medicinal products (ATMP) in the European Union (EU) are regulated by Regulation 1394/2007 and comprise gene and cell therapy and...
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Predicting potential adverse events using safety data from marketed drugs
BackgroundWhile clinical trials are considered the gold standard for detecting adverse events, often these trials are not sufficiently powered to...
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Biopharmaceuticals: New Frontier
Biopharma is the application of living organism or active ingredient extracted from biological system from its original form or genetically modified...
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Intracellular Cardiac Signaling Pathways Altered by Cancer Therapies
Recent advancements in targeted and immune-specific cancer therapies have improved patient survivorship. Specifically, tyrosine kinase inhibitors...
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A simple method for exploring adverse drug events in patients with different primary diseases using spontaneous reporting system
BackgroundPatient background (e.g. age, sex, and primary disease) is an important factor to consider when monitoring adverse drug events (ADEs) for...
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The factors affecting the development of medicinal plants from a value chain perspective
Main conclusionFrom a value chain perspective, this paper examines the important factors from the selection of planting areas to storage, which...
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Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction
Remdesivir is an antiviral drug used for COVID-19 treatment worldwide. Cardiovascular side effects have been associated with remdesivir; however, the...
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Ideas for how informaticians can get involved with COVID-19 research
The coronavirus disease 2019 (COVID-19) pandemic has had a significant impact on population health and wellbeing. Biomedical informatics is central...
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Treating diabetes with combination of phosphodiesterase 5 inhibitors and hydroxychloroquine—a possible prevention strategy for COVID-19?
Type 2 diabetes (T2D) is one of the major risk factors for develo** cardiovascular disease and the resultant devastating morbidity and mortality....
