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Identification of tubulointerstitial genes and ceRNA networks involved in diabetic nephropathy via integrated bioinformatics approaches
BackgroundDiabetic nephropathy (DN) is the major cause of end-stage renal disease worldwide. The mechanism of tubulointerstitial lesions in DN is not...
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Mesenchymal stem cells exosomal let-7a-5p improve autophagic flux and alleviate liver injury in acute-on-chronic liver failure by promoting nuclear expression of TFEB
Acute-on-chronic liver failure is a distinct clinical syndrome characterized by a dysregulated immune response and extensive hepatocyte death without...
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PTEN alleviates maladaptive repair of renal tubular epithelial cells by restoring CHMP2A-mediated phagosome closure
Phosphatase and Tensin Homolog on chromosome Ten (PTEN) has emerged as a key protein that governs the response to kidney injury. Notably, renal...
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A new vulnerability to BET inhibition due to enhanced autophagy in BRCA2 deficient pancreatic cancer
Pancreatic cancer is one of the deadliest diseases in human malignancies. Among total pancreatic cancer patients, ~10% of patients are categorized as...
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Golgi requires a new casting in the screenplay of mucopolysaccharidosis II cytopathology
Lysosome (L), a hydrolytic compartment of the endo-lysosomal system (ELS), plays a central role in the metabolic regulation of eukaryotic cells....
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The mechanisms and roles of selective autophagy in mammals
Autophagy is a process that targets various intracellular elements for degradation. Autophagy can be non-selective — associated with the...
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Phosphoinositides signaling modulates microglial actin remodeling and phagocytosis in Alzheimer’s disease
Alzheimer’s disease is one of the neurodegenerative diseases, characterized by the accumulation of abnormal protein deposits, which disrupts signal...
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Function and regulation of Rab GTPases in cancers
The Rab small GTPases are characterized by the distinct intracellular localization and modulate various endocytic, transcytic and exocytic transport...
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Protein degradation-associated mechanisms that are affected in Alzheimer´s disease
Alzheimer’s disease (AD) is the most common type of dementia associated with age-related neurodegeneration. Alteration of several molecular...
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Autophagy-modulating biomaterials: multifunctional weapons to promote tissue regeneration
Autophagy is a self-renewal mechanism that maintains homeostasis and can promote tissue regeneration by regulating inflammation, reducing oxidative...
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NDK/NME proteins: a host–pathogen interface perspective towards therapeutics
No effective vaccine is available for any parasitic disease. The treatment to those is solely dependent on chemotherapy, which is always threatened...
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The involvement of α-synucleinopathy in the disruption of microglial homeostasis contributes to the pathogenesis of Parkinson’s disease
The intracellular deposition and intercellular transmission of α-synuclein (α-syn) are shared pathological characteristics among neurodegenerative...
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Endocytosis and Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and is the most common cause of dementia. The pathogenesis of AD still remains...
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Autophagy in healthy aging and disease
Autophagy is a fundamental cellular process that eliminates molecules and subcellular elements, including nucleic acids, proteins, lipids and...
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Heterozygous expression of the Alzheimer’s disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses
BackgroundA rare coding variant, P522R , in the phospholipase C gamma 2 ( PLCG2) gene has been identified as protective against late-onset Alzheimer’s...
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Revolutionizing control strategies against Mycobacterium tuberculosis infection through selected targeting of lipid metabolism
Lipid species play a critical role in the growth and virulence expression of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis...
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Comparative Transcriptome Analysis of Head Kidney of Aeromonas hydrophila-infected Hypoxia-tolerant and Normal Large Yellow Croaker
The large yellow croaker ( Larimichthys crocea ) is one of the most economically important marine fish on the southeast coast of China and much of its...
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Diesel exhaust exposure alters the expression of networks implicated in neurodegeneration in zebrafish brains
Neurodegenerative diseases are a major cause of disability in the world, but their etiologies largely remain elusive. Genetic factors can only...
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Liposomes as Adjuvants and Vaccine Delivery Systems
AbstractThe review considers liposomes as systems of substantial interest as adjuvant carriers in vaccinology due to their versatility and maximal...
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Vitamin D3 Inhibits Phagocytic Activity of Rat Brain Astrocytes in Primary Culture
AbstractVitamin D deficiency is considered as a risk factor for neurodegenerative diseases associated with the accumulation of apoptotic...
