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Dynamic nucleosome organization after fertilization reveals regulatory factors for mouse zygotic genome activation
Chromatin remodeling is essential for epigenome reprogramming after fertilization. However, the underlying mechanisms of chromatin remodeling remain...
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Alternative signal pathways underly fertilization and egg activation in a fish with contrasting modes of spawning
BackgroundThe processes of fertilization and egg activation are vital for early embryogenesis. However, while the mechanisms associated with key...
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Influence of Immune System Activation in Early Ontogenesis on Aggressiveness and Sexual Motivation in Adult Wistar Rats
AbstractStresses in early ontogenesis can influence anxiety-depressive, defensive and social behavior, as well as the immune and hormonal reactivity...
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Epigenetic-related transcriptional reprogramming elucidated by identification and validation of a novel reference gene combination for RT-qPCR studies in porcine oocytes of contrasting quality
BackgroundReliable RT-qPCR results are dependent on appropriate normalisation. Oocyte maturation studies can be challenging in this respect, as the...
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RNA-Seq transcriptome reveals different molecular responses during human and mouse oocyte maturation and fertilization
BackgroundFemale infertility is a worldwide concern and the etiology of infertility has not been thoroughly demonstrated. Although the mouse is a...
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Casein kinase 2 modulates the spindle assembly checkpoint to orchestrate porcine oocyte meiotic progression
BackgroundCK2 (casein kinase 2) is a serine/threonine-selective protein kinase that has been involved in a variety of cellular processes such as DNA...
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Enhanced branched-chain amino acid metabolism improves age-related reproduction in C. elegans
Reproductive ageing is one of the earliest human ageing phenotypes, and mitochondrial dysfunction has been linked to oocyte quality decline; however,...
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Cordycepin delays postovulatory aging of oocytes through inhibition of maternal mRNAs degradation via DCP1A polyadenylation suppression
Postovulatory aging leads to the decline in oocyte quality and subsequent impairment of embryonic development, thereby reducing the success rate of...
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The walnut-derived peptide TW-7 improves mouse parthenogenetic embryo development of vitrified MII oocytes potentially by promoting histone lactylation
BackgroundPrevious studies have shown that the vitrification of metaphase II (MII) oocytes significantly represses their developmental potential....
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Cellular and molecular aspects of oocyte maturation and fertilization: a perspective from the actin cytoskeleton
AbstractMuch of the scientific knowledge on oocyte maturation, fertilization, and embryonic development has come from the experiments using gametes...
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Human follicular fluid proteome reveals association between overweight status and oocyte maturation abnormality
BackgroundHuman follicular fluid (HFF), which is composed by essential proteins required for the follicle development, provides an important...
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A paternal protein facilitates sperm RNA delivery to regulate zygotic development
Sperm contributes essential paternal factors, including the paternal genome, centrosome, and oocyte-activation signals, to sexual reproduction....
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Meiosis resumption in human primordial germ cells from induced pluripotent stem cells by in vitro activation and reconstruction of ovarian nests
BackgroundThe differentiation of human induced pluripotent stem cells (iPSCs) into oocytes, which involves the transformation from mitosis to...
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Silica nanoparticles induce ovarian granulosa cell apoptosis via activation of the PERK-ATF4-CHOP-ERO1α pathway-mediated IP3R1-dependent calcium mobilization
Ambient particulate matters (PMs) have adverse effects in human and animal female reproductive health. Silica nanoparticles (SNPs), as a major...
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Mitochondrial DNA Testing in Assisted Reproduction
In this chapter, the authors explain the role of mitochondrial DNA content to determine oocyte quality and implantation potential to increase the...
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Activation of non-classical NMDA receptors by glycine impairs barrier function of brain endothelial cells
Blood–brain barrier (BBB) integrity is necessary to maintain homeostasis of the central nervous system (CNS). NMDA receptor (NMDAR) function and...
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Histological and Transcriptomic Insights into the Ovary Development of Hemibarbus labeo Injected with Spawn-Inducing Hormones
Naturally, the ovaries of many farmed fish can only develop to stage IV (mainly including stage IV oocytes, known as full-grown postvitellogenic...
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Tropomyosin 1-I/C coordinates kinesin-1 and dynein motors during oskar mRNA transport
Dynein and kinesin motors mediate long-range intracellular transport, translocating towards microtubule minus and plus ends, respectively. Cargoes...
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The role of zinc in follicular development
Follicles consist of specialized somatic cells that encase a single oocyte. Follicle development is a process regulated by a variety of endocrine,...
