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SIRT1 activation attenuates palmitate induced apoptosis in C2C12 muscle cells
BackgroundType 2 diabetes is characterized by insulin resistance, which manifests mainly in skeletal muscles. SIRT1 has been found to play a role in...
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Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells
Muscle-specific tyrosine kinase myasthenia gravis (MuSK MG) is an autoimmune disease that causes life-threatening muscle weakness due to anti-MuSK...
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Vitamin D status modulates mitochondrial oxidative capacities in skeletal muscle: role in sarcopenia
Skeletal muscle mitochondrial function is the biggest component of whole-body energy output. Mitochondrial energy production during exercise is...
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Characteristics of nuclear architectural abnormalities of myotubes differentiated from LmnaH222P/H222P skeletal muscle cells
The presence of nuclear architectural abnormalities is a hallmark of the nuclear envelopathies, which are a group of diseases caused by mutations in...
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Pre-hibernation diet alters skeletal muscle relaxation kinetics, but not force development in torpid arctic ground squirrels
During the hibernation season, Arctic ground squirrels (AGS) experience extreme temperature fluctuations (body temperature, T b , as low as − 3 °C),...
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Hydrogen sulfide as a therapeutic option for the treatment of Duchenne muscular dystrophy and other muscle-related diseases
Hydrogen sulfide (H 2 S) has been known for years as a poisoning gas and until recently evoked mostly negative associations. However, the discovery of...
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Exons 45–55 Skip** Using Antisense Oligonucleotides in Immortalized Human DMD Muscle Cells
Antisense oligonucleotides (AOs) have demonstrated high potential as a therapy for treating genetic diseases like Duchene muscular dystrophy (DMD)....
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Role of the interaction between troponin T and AMP deaminase by zinc bridge in modulating muscle contraction and ammonia production
The N-terminal region of troponin T (TnT) does not bind any protein of the contractile machinery and the role of its hypervariability remains...
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Evaluating Therapeutic Activity of Galectin-1 in Sarcolemma Repair of Skeletal Muscle
Galectin-1 is a small (14.5 kDa) multifunctional protein with cell–cell and cell–ECM adhesion due to interactions with the carbohydrate recognition...
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Macroglossia and less advanced dystrophic change in the tongue muscle of the Duchenne muscular dystrophy rat
BackgroundDuchenne muscular dystrophy (DMD) is an X-linked muscle disease caused by a complete lack of dystrophin, which stabilizes the plasma...
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Integrating miRNA and full-length transcriptome profiling to elucidate the mechanism of muscle growth in Muscovy ducks reveals key roles for miR-301a-3p/ANKRD1
BackgroundThe popularity of Muscovy ducks is attributed not only to their conformation traits but also to their slightly higher content of breast and...
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Non-myogenic mesenchymal cells contribute to muscle degeneration in facioscapulohumeral muscular dystrophy patients
Muscle-resident non-myogenic mesenchymal cells play key roles that drive successful tissue regeneration within the skeletal muscle stem cell niche....
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Inhibition of the immunoproteasome modulates innate immunity to ameliorate muscle pathology of dysferlin-deficient BlAJ mice
Muscle repair in dysferlinopathies is defective. Although macrophage (Mø)-rich infiltrates are prominent in damaged skeletal muscles of patients with...
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Inhibition of myostatin and related signaling pathways for the treatment of muscle atrophy in motor neuron diseases
Myostatin is a negative regulator of skeletal muscle growth secreted by skeletal myocytes. In the past years, myostatin inhibition sparked interest...
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Absence of the Z-disc protein α-actinin-3 impairs the mechanical stability of Actn3KO mouse fast-twitch muscle fibres without altering their contractile properties or twitch kinetics
BackgroundA common polymorphism (R577X) in the ACTN3 gene results in the complete absence of the Z-disc protein α-actinin-3 from fast-twitch muscle...
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Metabolomic signatures for the longitudinal reduction of muscle strength over 10 years
BackgroundSkeletal muscles are essential components of the neuromuscular skeletal system that have an integral role in the structure and function of...
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Skeletal muscle phenoty** of Hippo gene-mutated mice reveals that Lats1 deletion increases the percentage of type I muscle fibers
The Hippo signal transduction network regulates transcription through Yap/Taz-Tead1-4 in many tissues including skeletal muscle. Whilst transgenic...
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Time-dependent unloading effects on muscle and bone and involvement of FNDC5/irisin axis
The identification of biomarkers and countermeasures to prevent the adverse effects on the musculoskeletal system caused by the absence of mechanical...
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Cardiac troponin T and autoimmunity in skeletal muscle aging
Age-related muscle mass and strength decline (sarcopenia) impairs the performance of daily living activities and can lead to mobility...
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Skeletal Muscle–Extricated Extracellular Vesicles: Facilitators of Repair and Regeneration
Skeletal muscle may be injured upon physical activity, or due to myofiber frailty caused by degenerative disorders. As a metabolic tissue, skeletal...