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Membrane lipids and maximum lifespan in clownfish
The longevity-homeoviscous adaptation (LHA) theory of ageing states that lipid composition of cell membranes is linked to metabolic rate and...
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Dopamine D1- and D2-like receptors oppositely regulate lifespan via a dietary restriction mechanism in Caenorhabditis elegans
BackgroundDespite recent progress in understanding the molecular mechanisms regulating aging and lifespan, and the pathways involved being conserved...
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Female-limited X chromosome evolution reveals that lifespan is mainly modulated by interlocus rather than intralocus sexual conflict
AbstractSexual dimorphism in somatic investment may be shaped by two distinct forms of sexual conflict; under intralocus sexual conflict (IASC),...
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The Evolution of Brain Size in Ectothermic Tetrapods: Large Brain Mass Trades-Off with Lifespan in Reptiles
The evolution of brain size is constrained by the trade-off between the energetic costs allocated towards its maintenance and the cognitive...
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NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health
Cells respond to many stressors by senescing, acquiring stable growth arrest, morphologic and metabolic changes, and a proinflammatory...
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Unraveling Pathways of Health and Lifespan with Integrated Multiomics Approaches
Distinct and shared pathways of health and lifespan can be untangled following a concerted approach led by experimental design and a rigorous...
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G protein-coupled receptors that influence lifespan of human and animal models
Humanity has always sought to live longer and for this, multiple strategies have been tried with varying results. In this sense, G protein-coupled...
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Berberis vulgaris L. extract supplementation exerts regulatory effects on the lifespan and healthspan of Drosophila through its antioxidant activity depending on the sex
Worldwide the aging population continues to increase, so the concept of healthy longevity medicine has become increasingly significant in modern...
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Biophysical mechanism underlying compensatory preservation of neural synchrony over the adult lifespan
We propose that the preservation of functional integration, estimated from measures of neural synchrony, is a key objective of neurocompensatory...
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The role of NAD and NAD precursors on longevity and lifespan modulation in the budding yeast, Saccharomyces cerevisiae
Molecular causes of aging and longevity interventions have witnessed an upsurge in the last decade. The resurgent interests in the application of...
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Gene-by-environment modulation of lifespan and weight gain in the murine BXD family
How lifespan and body weight vary as a function of diet and genetic differences is not well understood. Here we quantify the impact of differences in...
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Roles of tRNA metabolism in aging and lifespan
Transfer RNAs (tRNAs) mainly function as adapter molecules that decode messenger RNAs (mRNAs) during protein translation by delivering amino acids to...
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Decreased lifespan in female “Munchkin” actors from the cast of the 1939 film version of The Wizard of Oz does not support the hypothesis linking hypopituitary dwarfism to longevity
In laboratory mice, pituitary dwarfism caused by genetic reduction or elimination of the activity of growth hormone (GH) significantly extends...
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Fully hydrogenated canola oil extends lifespan in stroke-prone spontaneously hypertensive rats
BackgroundCanola oil (Can) and several vegetable oils shorten the lifespan of stroke-prone spontaneously hypertensive rats (SHRSP). Although similar...
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Prematurely aging female mice improve their behavioural response, immunity, redox state, and lifespan after a short social interaction with non-prematurely aging mice
Adult prematurely aging mice (PAM), characterized by inadequate stress response, show premature immunosenescence and shorter lifespan compared to...
