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What frog gill resorption brings: loss of function, cell death, and metabolic reorganization
BackgroundAnuran metamorphosis, which is driven by thyroid hormone (TH)-mediated processes, orchestrates intricate morphological and functional...
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Liver transcriptome analysis and identification of differentially expressed immune gene response to Aeromonas veronii infection in Channa argus
The Channa argus ( C. argus ), an important cultured freshwater species, is widely distributed in China, which possesses the characteristic of high...
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SARS-CoV-2 Receptors and Their Involvement in Cell Infection
AbstractThe new coronavirus infection (COVID-19) pandemic caused by SARS-CoV-2 has many times surpassed the epidemics caused by SARS-CoV and...
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Mechanisms of immune checkpoint inhibitors: insights into the regulation of circular RNAS involved in cancer hallmarks
Current treatment strategies for cancer, especially advanced cancer, are limited and unsatisfactory. One of the most substantial advances in cancer...
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Gangliosides as Siglec ligands
The structure of a sialoglycan can be translated into to a biological response when it binds to a specific endogenous lectin. Among endogenous sialic...
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Targeting the NF-κB pathway as a potential regulator of immune checkpoints in cancer immunotherapy
Advances in cancer immunotherapy over the last decade have led to the development of several agents that affect immune checkpoints. Inhibitory...
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Germline and Somatic Cell Syncytia in Insects
Syncytia are common in the animal and plant kingdoms both under normal and pathological conditions. They form through cell fusion or division of a...
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Transcriptome analysis of the endangered dung beetle Copris tripartitus (Coleoptera: Scarabaeidae) and characterization of genes associated to immunity, growth, and reproduction
BackgroundDung beetles recycle organic matter through the decomposition of feces and support ecological balance. However, these insects are...
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The Orchestra of Life
In which we find that a chance viral infection, harnessed by the vertebrate genome, led to the ability to create myriad pattern recognising molecules...
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Expression of Molecules Characterizing Metabolic and Cytotoxic Activity of Different Natural Killer Cell Subpopulations in Peripheral Blood during Pregnancy
AbstractThe functions of peripheral blood natural killer (NK) cells change significantly throughout pregnancy, which is mainly due to the inhibition...
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A review of the endangered mollusks transcriptome under the threatened species initiative of Korea
Transcriptome studies for conservation of endangered mollusks is a proactive approach towards managing threats and uncertainties facing these species...
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Super-enhancer-associated gene CAPG promotes AML progression
Acute myeloid leukemia is the most common acute leukemia in adults, the barrier of refractory and drug resistance has yet to be conquered in the...
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Three-dimensional Structure Databases of Biological Macromolecules
Databases of three-dimensional structures of proteins (and their associated molecules) provide:...
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Folding of newly synthesised proteins in the endoplasmic reticulum
The endoplasmic reticulum (ER) is a membranous compartment that can be found within any nucleated eukaryotic cell. Its job is to oversee the...
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Tight Junction Proteins as Emerging Drug Targets: Expanding the Horizons from Inflammation to Cancer
Tight junctions (TJ), located at the most topical part of the cells, are multi-protein complexes that form a formidable barrier governing the...
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The Rules of Social Engagement
In which we uncover the foundations of immunity in the social amoeba. We realise that our immune systems are not merely a means of fighting off...
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The role of Bach2 in regulating CD8 + T cell development and function
Bach2 was initially discovered in B cells, where it was revealed to control the transcription involved in cell differentiation. Bach2 is intimately...
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Comparative assessment of different anti-CD147/Basigin 2 antibodies as a potential therapeutic anticancer target by molecular modeling and dynamic simulation
Cluster of differentiation 147 (CD147) is an attractive target for anticancer therapy since it is pivotal in develo** and progressing several of...
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Domain Architecture Based Methods for Comparative Functional Genomics Toward Therapeutic Drug Target Discovery
G enes duplicate, mutate, recombine, fuse or fission to produce new genes, or when genes are formed from de novo , novel functions arise during...
