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Sensory neurons from dorsal root ganglia regulate endothelial cell function in extracellular matrix remodelling
BackgroundRecent physiological and experimental data highlight the role of the sensory nervous system in bone repair, but its precise role on...
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Occurrence of antibiotics and bacterial resistance genes in wastewater: resistance mechanisms and antimicrobial resistance control approaches
Antimicrobial pharmaceuticals are classified as emergent micropollutants of concern, implying that even at low concentrations, long-term exposure to...
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SMN-deficiency disrupts SERCA2 expression and intracellular Ca2+ signaling in cardiomyocytes from SMA mice and patient-derived iPSCs
Spinal muscular atrophy (SMA) is a neurodegenerative disease characterized by loss of alpha motor neurons and skeletal muscle atrophy. The disease is...
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The long noncoding RNA Synage regulates synapse stability and neuronal function in the cerebellum
The brain is known to express many long noncoding RNAs (lncRNAs); however, whether and how these lncRNAs function in modulating synaptic stability...
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Prepartum body conditions affect insulin signaling pathways in postpartum adipose tissues in transition dairy cows
BackgroundOverconditioned dairy cows are susceptible to excessive lipolysis and increased insulin resistance during the transition period. The...
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Helicobacter pylori treatment in the post-antibiotics era—searching for new drug targets
AbstractHelicobacter pylori , a member of Epsilonproteobacteria , is a Gram-negative microaerophilic bacterium that colonizes gastric mucosa of about...
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Characterization of distinct mutation patterns by CRISPR-Cas9 and CRISPR-Cpf1 genome editing systems
BackgroundsThe differences of DNA mutation patterns of genome editing by CRISPR (Clustered regularly interspaced Short Palindromic Repeats)-Cas9 and...
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Modulation of the extrinsic cell death signaling pathway by viral Flip induces acute-death mediated liver failure
During viral infections viruses express molecules that interfere with the host-cell death machinery and thus inhibit cell death responses. For...
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Inhibition of thyroid hormone signaling protects retinal pigment epithelium and photoreceptors from cell death in a mouse model of age-related macular degeneration
Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. Dry AMD is characterized by a progressive macular...
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Isolation and Purification of Satellite Cells from Young Rats by Percoll Density Gradient Centrifugation
Satellite cells (SCs) are myogenic stem cells that play an important role in skeletal muscle regeneration and hypertrophy. Primary cultures of SCs...
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Upregulation of large myelin protein zero leads to Charcot–Marie–Tooth disease-like neuropathy in mice
Charcot–Marie–Tooth (CMT) disease is a hereditary neuropathy mainly caused by gene mutation of peripheral myelin proteins including myelin protein...
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Mesocosm System to Evaluate BF-MBR Efficacy in Mitigating Oily Wastewater Discharges: an Integrated Study on Mytilus galloprovincialis
This work presents the results of recovery efficacy of the system “BioFilm Membrane BioReactor” (BF-MBR), in the treatment of oily contaminated...
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Identification of human endogenous retrovirus transcripts in Hodgkin Lymphoma cells
During the last decades, the prognosis for patients with Hodgkin Lymphoma (HL) has been steadily improved. Nevertheless, new and less toxic therapy...
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IFNβ enhances mesenchymal stromal (Stem) cells immunomodulatory function through STAT1-3 activation and mTOR-associated promotion of glucose metabolism
Administration of mesenchymal stem cells (MSC) ameliorate experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS),...
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Evaluation of the CRISPR/Cas9 directed mutant TP53 gene repairing effect in human prostate cancer cell line PC-3
Prostate cancer is a common health problem among men worldwide and most of these prostate cancer cases are related to a dysfunctional mutant Tumor...
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Evaluation of the expression stability of β-actin under bacterial infection in Macrobrachium nipponense
The selection of a suitable reference gene is an important prerequisite for the precise analysis of target gene expression by real-time quantitative...
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Ureide metabolism in plant-associated bacteria: purine plant-bacteria interactive scenarios under nitrogen deficiency
BackgroundThe erratic alterations in climate being experienced in agriculture, such as extended periods of drought or heavy rainfalls, are bringing...
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Anesthesia may alter mRNA expression of certain wound healing-associated genes in dermal wound environment of the rats
Some anesthetics including ketamine/xylazine and thiopental have been shown to alter the expression of genes related with inflammatory cytokines and...
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IMP/GTP balance modulates cytoophidium assembly and IMPDH activity
BackgroundInosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme in de novo GTP biosynthesis, plays an important role in cell...
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Biomimetic smoking robot for in vitro inhalation exposure compatible with microfluidic organ chips
Exposure of lung tissues to cigarette smoke is a major cause of human disease and death worldwide. Unfortunately, adequate model systems that can...
