Search
Search Results
-
The role of RNF149 in the pre-emptive quality control substrate ubiquitination
Protein quality control is a process in which a protein’s folding status is constantly monitored. Mislocalized proteins (MLP), are processed by the...
-
Protective effects of Ulva clathrata derived polyphenols against oxidative stress in lipopolysaccharide-induced RAW 264.7 cells via Nrf2/HO-1 pathway
Ulva clathrata is a common edible seaweed along the southeast coast of China and has been widely considered beneficial for human health. In the...
-
HGprt deficiency disrupts dopaminergic circuit development in a genetic mouse model of Lesch–Nyhan disease
In Lesch–Nyhan disease (LND), deficiency of the purine salvage enzyme hypoxanthine guanine phosphoribosyl transferase (HGprt) leads to a...
-
Peroxisomal very long-chain fatty acid transport is targeted by herpesviruses and the antiviral host response
Very long-chain fatty acids (VLCFA) are critical for human cytomegalovirus replication and accumulate upon infection. Here, we used Epstein-Barr...
-
Identification of reference genes for gene expression studies among different developmental stages of murine hearts
BackgroundReal-time quantitative polymerase chain reaction (RT-qPCR) is a widely-used standard assay for assessing gene expression. RT-qPCR data...
-
3′-tRF-CysGCA overexpression in HEK-293 cells alters the global expression profile and modulates cellular processes and pathways
tRNA fragments (tRFs) are small non-coding RNAs generated through specific cleavage of tRNAs and involved in various biological processes. Among the...
-
Desmoglein-2 is important for islet function and β-cell survival
Type 1 diabetes is a complex disease characterized by the lack of endogenous insulin secreted from the pancreatic β-cells. Although β-cell targeted...
-
Expression of Synj2bp in mouse liver regulates the extent of wrappER-mitochondria contact to maintain hepatic lipid homeostasis
BackgroundIn mouse liver hepatocytes, nearly half of the surface area of every mitochondrion is covered by wrappER, a wrap**-type of ER that is...
-
Autophagy modulation effect on homotypic transfer of intracellular components via tunneling nanotubes in mesenchymal stem cells
BackgroundRecent studies have proved the role of autophagy in mesenchymal stem cell (MSCs) function and regenerative properties. How and by which...
-
Application of CHyMErA Cas9-Cas12a combinatorial genome-editing platform for genetic interaction map** and gene fragment deletion screening
CRISPR-based forward genetic screening represents a powerful approach for the systematic characterization of gene function. Recent efforts have been...
-
Susceptibility genes of hyperuricemia and gout
Gout is a chronic metabolic disease that seriously affects human health. It is also a major challenge facing the world, which has brought a heavy...
-
The role of ubiquitin signaling pathway on liver regeneration in rats
The ubiquitin signalling pathway is a large system associated with numerous intracellular mechanisms. However, its function in the liver regeneration...
-
Augmenting and directing long-range CRISPR-mediated activation in human cells
Epigenetic editing is an emerging technology that uses artificial transcription factors (aTFs) to regulate expression of a target gene. Although...
-
Inhibition of the Expression of NRF2 Transcription Factor Mediated by miR-155 Causes a Decrease in the Viability of Melanoma Cells Regardless of Redox Status
AbstractThe NFE2L2 gene of the redox-sensitive transcription factor NRF2 is a target of miR-155 microRNA. In the present work, a transfection of...
-
Comparative transcriptome profile of embryos at different developmental stages derived from somatic cell nuclear transfer (SCNT) and in-vitro fertilization (IVF) in riverine buffalo (Bubalus bubalis)
Somatic cell nuclear transfer (SCNT) is a very important reproductive technology with many diverse applications, such as fast multiplication of elite...
-
Rapid Pacing Decreases L-type Ca2+ Current and Alters Cacna1c Isogene Expression in Primary Cultured Rat Left Ventricular Myocytes
The L-type calcium current (I CaL ) is the first step in cardiac excitation–contraction-coupling and plays an important role in regulating...
-
Establishment of an immortalized human erythroid cell line sustaining differentiation potential without inducible gene expression system
Ex vivo manufactured red blood cells (RBC) generated from immortalized erythroid cell lines which can continuously grow are expected to become a...
-
3′-Sialyllactose alleviates bone loss by regulating bone homeostasis
Osteoporosis is a common skeletal disease that results in an increased risk of fractures. However, there is no definitive cure, warranting the...
-
SARS-CoV-2 NSP13 helicase suppresses interferon signaling by perturbing JAK1 phosphorylation of STAT1
BackgroundSARS-CoV-2 is the causative agent of COVID-19. Overproduction and release of proinflammatory cytokines are the underlying cause of severe...
-
Osteogenic differentiation of human induced pluripotent stem cell in the presence of testosterone and 17 β-estradiol in vitro
Recently, numerous scientific approaches have been explored to treat various diseases using stem cells. In 2006, induced pluripotent stem cell (iPSC)...
