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Designing Biomimicking Synthetic Transcription Factors for Therapeutic Gene Modulation
Inside living cells, natural transcription factors operate by precisely recognizing specific DNA sequences and by recruiting transcription ON/OFF...
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NAC transcription factor NOR-like1 regulates tomato fruit size
Main conclusionNOR-like1 regulates tomato fruit size by targeting SlARF9 , SlGRAS2 , SlFW3 .2, and SlFW11 .3 genes involved in cell division and cell...
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Elongation roadblocks mediated by dCas9 across human genes modulate transcription and nascent RNA processing
Non-cleaving Cas9 (dCas9) is widely employed to manipulate specific gene loci, often with scant regard for unintended transcriptional effects. We...
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The BulkECexplorer compiles endothelial bulk transcriptomes to predict functional versus leaky transcription
Transcriptomic data can be mined to understand the molecular activity of cell types. Yet, functional genes may remain undetected in RNA sequencing...
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A Survey of Transcription Factors in Cell Fate Control
Transcription factors (TFs) play a cardinal role in the development and maintenance of human physiology by acting as mediators of gene expression and...
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Simultaneous profiling of chromatin architecture and transcription in single cells
The three-dimensional structure of chromatin plays a crucial role in development and disease, both of which are associated with transcriptional...
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Effects of ScRgt1-Like DNA-binding transcription factor SpRgt1 (SPCC320.03) on Hexose transporters gene expression in Schizosaccharomyces pombe
Glucose, which plays an essential role in carbon and energy metabolism in eukaryotes, is vital in directing various energy-consuming cellular...
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Orthogonal control of gene expression in plants using synthetic promoters and CRISPR-based transcription factors
BackgroundThe construction and application of synthetic genetic circuits is frequently improved if gene expression can be orthogonally controlled,...
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Quantitative Real-Time PCR Method to Evaluate Gene Expression in Zebrafish Embryos
The fast zebrafish embryonic development offers an opportunity for the study of genes crucial for developmental processes. Several genes associated...
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Molecular Basis of Cell Reprogramming into iPSCs with Exogenous Transcription Factors
A striking discovery in recent decades concerning the transcription factor (TF)-dependent process was the production of induced pluripotent stem cell...
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Transcription factor ATMIN facilitates chemoresistance in nasopharyngeal carcinoma
Despite that the docectaxel-cisplatin-5-fluorouracil (TPF) induction chemotherapy has greatly improved patients’ survival and became the first-line...
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Histone Ubiquitylation and the Regulation of Transcription
The small (76 amino acids) and highly conserved ubiquitin protein plays key roles in the physiology of eukaryotic cells. Protein ubiquitylation...
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PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency
The Polycomb repressive system plays a fundamental role in controlling gene expression during mammalian development. To achieve this, Polycomb...
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Transcription Factors of the GLRs Family Are Involved in Cytokinin-Dependent Regulation of Plastid RNA Polymerase SCA3 Gene Expression during Deetiolation of Arabidopsis thaliana
AbstractLight-dependent transcription factors GLKs of Arabidopsis thaliana are involved in the anterograde regulation of chloroplast biogenesis...
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Building High-Confidence Gene Regulatory Networks by Integrating Validated TF–Target Gene Interactions Using ConnecTF
Many methods are now available to identify or predict the target genes of transcription factors (TFs) in plants. These include experimental...
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Co-transcriptional gene regulation in eukaryotes and prokaryotes
Many steps of RNA processing occur during transcription by RNA polymerases. Co-transcriptional activities are deemed commonplace in prokaryotes, in...
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Transcription readthrough is prevalent in healthy human tissues and associated with inherent genomic features
Transcription termination is a crucial step in the production of conforming mRNAs and functional proteins. Under cellular stress conditions, the...
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Heterologous expression of the maize transcription factor ZmbHLH36 enhances abiotic stress tolerance in Arabidopsis
Basic helix-loop-helix (bHLH) transcription factors are widely distributed in eukaryotes, and in plants, they regulate many biological processes,...
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Sex-Biased Transcription Expression of Vitellogenins Reveals Fusion Gene and MicroRNA Regulation in the Sea Louse Caligus rogercresseyi
The caligid ectoparasite, Caligus rogercresseyi , is one of the main concerns in the Chilean salmon industry. The molecular mechanisms displayed by...
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Light-harvesting complex gene regulation by a MYB-family transcription factor in the marine diatom, Phaeodactylum tricornutum
Unicellular photoautotrophs adapt to variations in light intensity by changing the abundance of light harvest pigment-protein complexes (LHCs) on...
