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A day in the life of the spliceosome
One of the most amazing findings in molecular biology was the discovery that eukaryotic genes are discontinuous, with coding DNA being interrupted by...
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Genome-wide association study of sleep in Drosophila melanogaster
BackgroundSleep is a highly conserved behavior, yet its duration and pattern vary extensively among species and between individuals within species....
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Gene rearrangements in hormone receptor negative breast cancers revealed by mate pair sequencing
BackgroundChromosomal rearrangements in the form of deletions, insertions, inversions and translocations are frequently observed in breast cancer...
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Variable Lymphocyte Receptors in Jawless Vertebrates: Illuminating the Origin and Early Evolution of Adaptive Immunity
Phylogenetic studies of immunity have revealed that about 500 million years ago, two types of recombinatorial adaptive immune systems (AIS) arose in...
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Euchromatin islands in large heterochromatin domains are enriched for CTCF binding and differentially DNA-methylated regions
BackgroundThe organization of higher order chromatin is an emerging epigenetic mechanism for understanding development and disease. We and others...
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Dscam mutation leads to hydrocephalus and decreased motor function
The nervous system is one of the most complicated organ systems in invertebrates and vertebrates. Down syndrome cell adhesion molecule (DSCAM) of the...
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Evolution and Function of SPARC and Tenascins: Matricellular Counter-Adhesive Glycoproteins with Pleiotropic Effects on Angiogenesis and Tissue Fibrosis
The evolution of multicellular organisms composed of tissues with distinct morphologies and physiological functions has involved the appearance of...
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Alternative splicing: a pivotal step between eukaryotic transcription and translation
Alternative splicing was discovered simultaneously with splicing over three decades ago. Since then, an enormous body of evidence has demonstrated...
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Distinct and overlap** gene regulatory networks in BMP- and HDAC-controlled cell fate determination in the embryonic forebrain
BackgroundBoth bone morphogenetic proteins (BMPs) and histone deacetylases (HDACs) have previously been established to play a role in the development...
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Elucidating the In Vivo Targets of Photorhabdus Toxins in Real-Time Using Drosophila Embryos
The outcome of any bacterial infection, whether it is clearance of the infecting pathogen, establishment of a persistent infection, or even death of...
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Splicing of mouse p53 pre-mRNA does not always follow the “first come, first served” principle and may be influenced by cisplatin treatment and serum starvation
Transcription of a pre-mRNA in eukaryotic cells elongates from the 5′ to the 3′ end, but intron removal during a pre-mRNA splicing does not always...
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The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks
Alcoholism is a significant public health problem. A picture of the genetic architecture underlying alcohol-related phenotypes is emerging from...
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Predicting mutually exclusive spliced exons based on exon length, splice site and reading frame conservation, and exon sequence homology
BackgroundAlternative splicing of pre-mature RNA is an important process eukaryotes utilize to increase their repertoire of different protein...
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SNP and gene networks construction and analysis from classification of copy number variations data
BackgroundDetection of genomic DNA copy number variations (CNVs) can provide a complete and more comprehensive view of human disease. It is...
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RNA secondary structure in mutually exclusive splicing
Mutually exclusive splicing is a regulated means to generate protein diversity, but the underlying mechanisms are poorly understood. Here comparative...
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Neurexins and neuroligins: synapses look out of the nervous system
The scientific interest in the family of the so-called nervous vascular parallels has been growing steadily for the past 15 years, either by addition...
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Axonal commissures in the central nervous system: how to cross the midline?
Organisms with bilateral symmetry elaborate patterns of neuronal projections connecting both sides of the central nervous system at all levels of the...
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Effect of exonic splicing regulation on synonymous codon usage in alternatively spliced exons of Dscam
BackgroundSynonymous codon usage is typically biased towards translationally superior codons in many organisms. In Drosophila , genomic data...
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L1CAM malfunction in the nervous system and human carcinomas
Research over the last 25 years on the cell adhesion molecule L1 has revealed its pivotal role in nervous system function. Mutations of the human L1CAM ...
