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Knotting terminal ends of mutant T1 lipase with disulfide bond improved structure rigidity and stability
AbstractLipase biocatalysts offer unique properties which are often impaired by low thermal and methanol stability. In this study, the rational...
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Structure of the actively translating plant 80S ribosome at 2.2 Å resolution
In plant cells, translation occurs in three compartments: the cytosol, the plastids and the mitochondria. While the structures of the...
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Elucidation of brefeldin A-induced ER and Golgi stress responses in Neuro2a cells
Brefeldin A (BFA) disrupts the structure of the Golgi apparatus to trigger ER stress signaling pathways. On the other hand, treatment with BFA...
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Advances and opportunities in RNA structure experimental determination and computational modeling
Beyond transferring genetic information, RNAs are molecules with diverse functions that include catalyzing biochemical reactions and regulating gene...
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Elucidation of Gene Expression Patterns in the Craniofacial Tissues of Mouse Embryos by Wholemount In Situ Hybridization
Analysis of animal models allows a deeper understanding of craniofacial development in health and diseases of humans. Wholemount in situ...
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MAVEN: compound mechanism of action analysis and visualisation using transcriptomics and compound structure data in R/Shiny
BackgroundUnderstanding the Mechanism of Action (MoA) of a compound is an often challenging but equally crucial aspect of drug discovery that can...
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Construction of white-rot fungal-bacterial consortia with improved ligninolytic properties and stable bacterial community structure
It is believed that wood-rot fungi change their wood decay activities due to influences from co-existing bacterial communities; however, it is...
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RNA Versus Protein, How Structure Influences Targeting, a New Challenge for Drug Discovery
Unlike other large biomolecules, RNA carries two main tasks: an informational coding potential governed by its sequence and a catalytic/regulatory...
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Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis
Sphingomyelin (SM) has key roles in modulating mammalian membrane properties and serves as an important pool for bioactive molecules. SM biosynthesis...
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Structure, preparation, and biological activity of sulfated polysaccharides from the genus Caulerpa (Chlorophyta): A review
Seaweeds have garnered attention in recent years as a potential source of useful metabolites and bioactive compounds. The genus Caulerpa , with...
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Acidophilic structure and killing mechanism of the Pichia farinosa killer toxin SMKT
SMKT, a killer toxin produced by a halotolerant yeast Pichia farinosa that consists of α and β subunits, is generated from a chromosomally encoded...
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Neddylation regulation of mitochondrial structure and functions
Mitochondria are the powerhouse of a cell. The structure and function of mitochondria are precisely regulated by multiple signaling pathways....
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Genome Structure of Triticeae Species
This chapter describes characteristic features of the chromosomes and genomes of Triticeae species. Centromeres contain typical CENH3 nucleosomes,...
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Elucidation of the K32 Capsular Polysaccharide Structure and Characterization of the KL32 Gene Cluster of Acinetobacter baumannii LUH5549
Capsular polysaccharide (CPS), isolated from Acinetobacter baumannii LUH5549 carrying the KL32 capsule biosynthesis gene cluster, was studied by...
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Environment influences the genetic structure and genetic differentiation of Sassafras tzumu (Lauraceae)
BackgroundSassafras tzumu , an elegant deciduous arboreal species, belongs to the esteemed genus Sassafras within the distinguished family Lauraceae....
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Vascular bundle xylem water transport repression and cell anatomical structure differences may lead to berry cracking near the proximal end
Grape berries often crack near the proximal end, which may be related to water absorption and their cellular anatomical structure. To study the...
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Whole-genome sequencing revealed genetic diversity, structure and patterns of selection in Guizhou indigenous chickens
BackgroundThe eight phenotypically distinguishable indigenous chicken breeds in Guizhou province of China are great resources for high-quality...
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Structure determination of inactive-state GPCRs with a universal nanobody
Cryogenic electron microscopy (cryo-EM) has widened the field of structure-based drug discovery by allowing for routine determination of membrane...
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Elucidation of the GAUT gene family in eight Rosaceae species and function analysis of PbrGAUT22 in pear pollen tube growth
Main conclusionThe phylogenetic relationship and evolutionary history of the GAUT gene family were identified in 8 Rosaseae species. PbrGAUT22 was...
