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Identification of genotype–biochemical phenotype correlations associated with fructose 1,6-bisphosphatase deficiency
Fructose-1,6-bisphosphatase (FBPase) deficiency, caused by an FBP1 mutation, is an autosomal recessive disorder characterized by hypoglycemic lactic...
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Colitis-associated carcinogenesis: crosstalk between tumors, immune cells and gut microbiota
Colorectal cancer (CRC) is the third most common cancer worldwide. One of the main causes of colorectal cancer is inflammatory bowel disease (IBD),...
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Marginal Maternal Zinc Deficiency Produces Liver Damage and Altered Zinc Transporter Expression in Offspring Male Rats
The aim of this study was to investigate how zinc deficiency and supplementation affect liver markers including autotaxin, kallistatin, endocan, and...
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Transcriptomics to Dissect the Immune System
The immune system functions to protect the host from diverse pathogenic microorganisms as well as cancers, where transcriptional regulations in...
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α4 Integrins in Immune Homeostasis and Disease
α4 integrins (including α4β1 and α4β7) are primarily expressed on leukocytes. By interacting with their ligands expressed on high endothelial venules...
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Food Products of Non–plant Origin to Combat the Problem of Nutritional Deficiency
The macronutrients such as carbohydrates, proteins, and lipids are required for energy and the micronutrients such as vitamins and minerals are...
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TIGIT, a novel immune checkpoint therapy for melanoma
Melanoma is the most aggressive and deadliest type of skin cancer. In the last 10 years, immune checkpoint blockades (ICBs) including PD-1/PD-L1 and...
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EHHADH deficiency regulates pexophagy and accelerates tubulointerstitial injury in diabetic kidney disease
Peroxisomal l -bifunctional enzyme (EHHADH) plays a role in the classic peroxisomal fatty acid β-oxidation pathway; however, the relationship between...
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Activation of innate immune cGAS-STING pathway contributes to Alzheimer’s pathogenesis in 5×FAD mice
cGAS senses microbial and host-derived double-stranded DNA in cytoplasm to trigger cellular innate immune response in a STING-dependent manner;...
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Association of Immune Cell Subsets with Incident Hip Fracture: The Cardiovascular Health Study
In this study, we aimed to evaluate the association of innate and adaptive immune cell subsets in peripheral blood mononuclear cells (PBMCs) with hip...
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SMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy
Beyond motor neuron degeneration, homozygous mutations in the survival motor neuron 1 ( SMN1 ) gene cause multiorgan and metabolic defects in patients...
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Association of Probiotics and Prebiotics with Human Microbiome and the Functioning of Immune System
The evolution of mutualism and homeostasis between mammals and their commensal microorganisms makes sense from an ecological perspective. Microbiota...
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Single-cell sequencing resolves the landscape of immune cells and regulatory mechanisms in HIV-infected immune non-responders
Immune non-responder after highly active antiretroviral therapy (HAART) is the main cause of opportunistic infections and high mortality in AIDS...
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ALOX5 deficiency contributes to bladder cancer progression by mediating ferroptosis escape
Ferroptosis is an iron-dependent form of regulated cell death driven by the lethal lipid peroxides. Previous studies have demonstrated that inducing...
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The F-bZIP-regulated Zn deficiency response in land plants
Main conclusionThis review describes zinc sensing and transcriptional regulation of the zinc deficiency response in Arabidopsis, and discusses how...
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Autophagy deficiency protects against ocular hypertension and neurodegeneration in experimental and spontaneous glaucoma mouse models
Glaucoma is a group of diseases that leads to chronic degeneration of retinal ganglion cell (RGC) axons and progressive loss of RGCs, resulting in...
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Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions
Inflammation in the central nervous system can impair the function of neuronal mitochondria and contributes to axon degeneration in the common...
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A review of immune modulators and immunotherapy in infectious diseases
The human immune system responds to harmful foreign invaders frequently encountered by the body and employs defense mechanisms to counteract such...
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Deubiquitinating enzymes: potential regulators of the tumor microenvironment and implications for immune evasion
Ubiquitination and deubiquitination are important forms of posttranslational modification that govern protein homeostasis. Deubiquitinating enzymes...
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PRMT1 reverts the immune escape of necroptotic colon cancer through RIP3 methylation
Necroptosis plays a double-edged sword role in necroptotic cancer cell death and tumor immune escape. How cancer orchestrates necroptosis with immune...
